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STRADA

Official Full Name

STE20-related kinase adaptor alpha
Overview

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
Synonyms

STRADA; STE20-related kinase adaptor alpha; STE20-related kinase adapter protein alpha; LYK5; NY BR 96; STE20 like pseudokinase; Stlk; STRAD; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	STRADA-449H	Recombinant Human STRADA Protein, His-tagged	E.coli	His		Inquiry
Human	STRADA-229H	Recombinant Human STRADA, His-tagged	E.coli	His	1-314aa	Inquiry
Human	STRADA-1041HCL	Recombinant Human STRADA cell lysate		N/A		Inquiry
Human	STRADA-6235HF	Recombinant Full Length Human STRADA Protein, GST-tagged	In Vitro Cell Free System	GST	348 amino acids	Inquiry
Human	STRADA-4560H	Recombinant Human STRADA Protein, GST-tagged	Wheat Germ	GST		Inquiry
Rat	STRADA-5804R	Recombinant Rat STRADA Protein	Mammalian Cell	His		Inquiry
Rat	STRADA-5463R	Recombinant Rat STRADA Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	STRADA-5463R-B	Recombinant Rat STRADA Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	STRADA-10280Z	Recombinant Zebrafish STRADA	Mammalian Cell	His		Inquiry
Chicken	STRADA-2068C	Recombinant Chicken STRADA	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
STRADA Related Articles
STRADA Related Signal Pathway

STRADA involved in several pathways and played different roles in them. We selected most pathways STRADA participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mTOR signaling pathway	PDPK1B;RPS6KA2;TNF;EIF4E2;RHEB;RICTOR;ULK3;AKT2L;PRKAA2
AMPK signaling pathway	PRKAB2;CAB39L;Scd1;CCNA2;RAB2A;CREB3;PIK3R2;INSR;FBP2

STRADA has several biochemical functions, for example, ATP binding, NOT Rac GTPase binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADA itself. We selected most functions STRADA had, and list some proteins which have the same functions with STRADA. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ABCG2;HELB;FGFR1B;P2RX3;DAK;UBA3;CHD2;ACTR3B;LATS2
NOT Rac GTPase binding	STRADB;STRADA
kinase binding	FAS;PPP2R5A;ATF5;TNFAIP3;HSP90AB1;DLG4;RPS3;BCL10;DLG3
protein binding	MTTP;ARHGAP1;PPEF1;DGKQ;P4HA3;MATN1;EIF5;TDRD7;ELMOD3
protein kinase activator activity	PRKAG2;FGF13;WNT11;EPO;DUSP19;MAPK8IP2;FAM58A;CAB39;GPRC5B
NOT protein kinase activity	TRIB1;TRIB2;STRADB;HSPB8;STRADA;PXK;MLKL
protein serine/threonine kinase activator activity	STK3;FAM20A;CDK5R1;SPRY2;STRADA;STK4;LTF;CALM2;CALM3
NOT protein serine/threonine kinase activity	STRADB;FAM20A;SNX15;STRADA

STRADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADA here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADA.

STK11; CAB39

Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).

Sugden, PH; McGuffin, LJ; et al. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. BIOCHEMICAL JOURNAL 454:13-30(2013).