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STRADB

Official Full Name

STE20-related kinase adaptor beta
Overview

Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, only the shorter isoform has been observed.
Synonyms

Stradb; STE20-related kinase adaptor beta; Papk; ILPIP; ILPIPA; Syradb; Als2cr2; D1Ucla2; PRO1038; AA792893; B830008M19; STE20-related kinase adapter protein beta; STRAD beta; OTTMUSP00000022732; pseudokinase ALS2CR2; ILP-interacting protein homolog; polyploidy associated protein kinase; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; Polyploidy-associated protein kinase; CALS-21;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	STRADB-1385HCL	Recombinant Human STRADB 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	STRADB-16171M	Recombinant Mouse STRADB Protein	Mammalian Cell	His	Inquiry
Mouse	STRADB-8827M	Recombinant Mouse STRADB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	STRADB-8827M-B	Recombinant Mouse STRADB Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	STRADB-4536R	Recombinant Rhesus monkey STRADB Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	STRADB-4352R-B	Recombinant Rhesus Macaque STRADB Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	STRADB-4352R	Recombinant Rhesus Macaque STRADB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
STRADB Related Articles

STRADB involved in several pathways and played different roles in them. We selected most pathways STRADB participated on our site, such as AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
AMPK signaling pathway	PPP2R5D;SREBF1;PPARGC1A;PIK3CB;RAB14;PPP2R5B;CREB3L2;PFKL;CAMKK2

STRADB has several biochemical functions, for example, ATP binding, NOT Rac GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADB itself. We selected most functions STRADB had, and list some proteins which have the same functions with STRADB. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	NME1;DGKB;ABCF3;TTLL6;RUVBL1;PKMYT1;TYRO3;VRK3;RAF1A
NOT Rac GTPase binding	STRADB;STRADA
protein binding	MYBPC3;TMED5;ICAM3;RAB9A;CLOCK;GAGE5;BTF3L4;C10orf81;TEKT1
NOT protein kinase activity	PXK;STRADB;TRIB2;MLKL;STRADA;TRIB1;HSPB8
NOT protein serine/threonine kinase activity	STRADA;STRADB;FAM20A;SNX15

STRADB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADB here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADB.

STK11; CAB39; Dlg4; NEB; GRB2

Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).

Mikryukov, A; Moss, T; et al. Agonistic and Antagonistic Roles for TNIK and MINK in Non-Canonical and Canonical Wnt Signalling. PLOS ONE 7:-(2012).