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SULF2

  • Official Full Name

    sulfatase 2

  • Overview

    Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and;are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate;groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for;signaling molecules (Dai et al., 2005 (PubMed 16192265)).
  • Synonyms

    SULF2; sulfatase 2; extracellular sulfatase Sulf-2; HSULF 2; KIAA1247; SULF 2; Extracellular sulfatase Sulf 2; HSulf-2; HSulf2; SULF2_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Flavobacterium heparinum
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SULF2-3045H Recombinant Human SULF2, GST-tagged E.coli GST C-term-149aa
Human SULF2-963H Recombinant Human SULF2 Mammalian Cell His
Human SULF2-1358HCL Recombinant Human SULF2 293 Cell Lysate HEK293 N/A
Human SULF2-1359HCL Recombinant Human SULF2 293 Cell Lysate HEK293 N/A
Human SULF2-4152H Recombinant Human SULF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SULF2-665H Recombinant Human SULF2 Protein, His/GST-tagged E.coli His/GST Phe337~Arg649
Human SULF2-6001H Recombinant Human SULF2 Protein (Phe337-Arg649), N-GST tagged E.coli N-GST Phe337-Arg649
Human SULF2-4152H-B Recombinant Human SULF2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SULF2-16218M Recombinant Mouse SULF2 Protein Mammalian Cell His
Mouse SULF2-8861M Recombinant Mouse SULF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Sulf2-666M Recombinant Mouse Sulf2 Protein, His-tagged E.coli His Phe337~Arg654
Mouse SULF2-8861M-B Recombinant Mouse SULF2 Protein Pre-coupled Magnetic Beads HEK293
Flavobacterium heparinum SULF2-02F Active Native Flavobacterium heparinum 2-O-Sulfatase N/A 843
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SULF2 Related Articles
  • SULF2 Related Research Area

SULF2 involved in several pathways and played different roles in them. We selected most pathways SULF2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SULF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

SULF2 has several biochemical functions, for example, N-acetylglucosamine-6-sulfatase activity, arylsulfatase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SULF2 itself. We selected most functions SULF2 had, and list some proteins which have the same functions with SULF2. You can find most of the proteins on our site.

Function Related Protein
N-acetylglucosamine-6-sulfatase activityGNSA;GNS;GNSB;SULF2;SULF1
arylsulfatase activityARSG;SULF2;ARSH;ARSA;ARSI;SULF1;ARSE;ARSK;ARSJ
calcium ion bindingUBE4A;NKD2;S100A10;CRELD2;SYTL2;PLS1;PCDHB16;SYT9B;PCDHB6

SULF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SULF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SULF2.

ligA

Singer, MS; Phillips, JJ; et al. SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis. CLINICA CHIMICA ACTA 440:72-78(2015).
Joy, MT; Vrbova, G; et al. Sulf1 and Sulf2 expression in the nervous system and its role in limiting neurite outgrowth in vitro. EXPERIMENTAL NEUROLOGY 263:150-160(2015).
Alhasan, AA; Spielhofer, J; et al. Role of 6-O-Sulfated Heparan Sulfate in Chronic Renal Fibrosis. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20295-20306(2014).
Lui, NS; van Zante, A; et al. SULF2 expression by immunohistochemistry and overall survival in oesophageal cancer: a cohort study. BMJ OPEN 2:-(2012).
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