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SUN2

Official Full Name

Sad1 and UNC84 domain containing 2
Overview

UNC84B (Protein UNC-84 homolog B or SUN2),Is a single-pass nuclear envelope transmembrane protein responsible for nuclear migrations that are essential for development. UNC-84B has a predicted transmembrane domain and a C-terminal region with similarity to the S. pombe spindle pole body protein Sad1. UNC-84B interacts with RAB5A and is widely expressed, and highly expressed in the heart, lungs and muscles. UNC-84 may function to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage.
Synonyms

SUN2; Sad1 and UNC84 domain containing 2; unc 84 homolog B (C. elegans) , UNC84B; SUN domain-containing protein 2; rab5IP; unc-84 homolog B; nuclear envelope protein; protein unc-84 homolog B; rab5-interacting protein; sad1/unc-84 protein-like 2; Sad1 unc-84 domain protein 2; UNC84B; KIAA0668; MGC133055; MGC133056;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)

Source

E.coli expression system
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SUN2-1989H	Recombinant Human SUN2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	SUN2-3017H	Recombinant Human SUN2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Mouse	SUN2-16241M	Recombinant Mouse SUN2 Protein	Mammalian Cell	His		Inquiry
Mouse	Sun2-6841M	Recombinant Mouse Sun2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SUN2-8874M	Recombinant Mouse SUN2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SUN2-8874M-B	Recombinant Mouse SUN2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL31386HF	Recombinant Full Length Human Sun Domain-Containing Protein 2(Sun2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-717)	Inquiry
Mus musculus (Mouse)	RFL29314MF	Recombinant Full Length Mouse Sun Domain-Containing Protein 2(Sun2) Protein, His-Tagged	E.coli expression system	His	Full Length (1-731)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
SUN2 Related Articles

SUN2 involved in several pathways and played different roles in them. We selected most pathways SUN2 participated on our site, such as Meiotic Synapsis, Mus musculus biological processes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Meiotic Synapsis	TEX12;SYCP2;TERF2;TERF1;SUN1;SYNE2;POT1A;TERF2IP;POT1
Mus musculus biological processes	POT1A;SYNE2;SYCP1;SUN2;SYCE2;KLF5;MED11

SUN2 has several biochemical functions, for example, identical protein binding, lamin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUN2 itself. We selected most functions SUN2 had, and list some proteins which have the same functions with SUN2. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	COL18A1;CCDC155;HNRNPC;CLPP;NUFIP1;DDX58;GNPNAT1;BLOC1S6;KLHL7
lamin binding	LBR;SUN1;TMEM201;TMPO;PPP4C;TOR1AIP1;NARF;SYNE1;PKP1
protein binding	PRKACB;TMX3;MAGEA2B;INADL;MRPL12;PEAK1;RFESD;TUBA3E;MAX

SUN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUN2.

Traf1

Varas, J; Graumann, K; et al. Absence of SUN1 and SUN2 proteins in Arabidopsis thaliana leads to a delay in meiotic progression and defects in synapsis and recombination. PLANT JOURNAL 81:329-346(2015).

Randles, KN; Lam, L; et al. Nesprins, But Not Sun Proteins, Switch Isoforms at the Nuclear Envelope During Muscle Development. DEVELOPMENTAL DYNAMICS 239:998-1009(2010).

Hodzic, DM; Yeater, DB; et al. Sun2 is a novel mammalian inner nuclear membrane protein. JOURNAL OF BIOLOGICAL CHEMISTRY 279:25805-25812(2004).