Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

SYN1

  • Official Full Name

    synapsin I

  • Overview

    This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Synonyms

    SYN1; synapsin I; SYNI; SYN1a; SYN1b; synapsin-1; brain protein 4.1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SYN1-1380H Recombinant Human SYN1 Protein, GST-tagged E.coli GST
Human SYN1-16H Recombinant Human SYN1, MYC/DDK-tagged HEK293 Myc/DDK
Human SYN1-4848H Recombinant Human SYN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SYN1-8826HFL Recombinant Full Length Human SYN1, Flag-tagged Mamanlian cells Flag
Human SYN1-1530H Recombinant Human SYN1 Protein (113-420 aa), His-tagged Yeast His 113-420 aa
Human SYN1-2673H Recombinant Human SYN1 protein(601-690 aa), C-His-tagged E. coli C-His 601-690 aa
Human SYN1-461HFL Recombinant Full Length Human SYN1 Protein, C-Flag-tagged Mammalian cells Flag
Human SYN1-2145H-B Recombinant Human SYN1 Protein Pre-coupled Magnetic Beads HEK293
Human SYN1-2145H Recombinant Human SYN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SYN1-6386H Recombinant Human SYN1 Protein (Gly160-Ile291), N-His tagged E.coli N-His Gly160-Ile291
Mouse Syn1-8136M Recombinant Mouse Syn1 protein, His & T7-tagged E.coli His/T7 Ala113~Arg420 (Accession # O88935)
Mouse Syn1-6247M Recombinant Mouse Syn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SYN1-5860R Recombinant Rat SYN1 Protein Mammalian Cell His
Rat SYN1-5519R-B Recombinant Rat SYN1 Protein Pre-coupled Magnetic Beads HEK293
Rat SYN1-5519R Recombinant Rat SYN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SYN1-6740Z Recombinant Zebrafish SYN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SYN1 Related Articles
  • SYN1 Related Research Area

SYN1 involved in several pathways and played different roles in them. We selected most pathways SYN1 participated on our site, such as BDNF signaling pathway, Dopamine Neurotransmitter Release Cycle, Monoamine Transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BDNF signaling pathwayEIF2S1;GRIP1;DPYSL2;CDK5;EGR1;MAP3K2;EEF2;SIRPA;EIF4EBP1
Dopamine Neurotransmitter Release CycleSYN2;SYN3;SYN1;RERG;LIN7B;UNC13B;PPFIA2;LIN7C;PPFIA1
Monoamine TransportTGFB1I1;SCAMP2;DBH;SYN1;UNC13B;FBXO32;HRH3;TPH2
Neuronal SystemKCNK6;AKAP5;CHRNA7;KCNQ1;KCNC2;KCNH1B;DLG1L;KCNF1A;SLC6A11
Neurotransmitter Release CycleSLC1A2A;SLC6A1B;PPFIA4;BZRAP1;SNAP25B;PPFIA2;SLC1A7A;SNAP25A;Apba1
Serotonin Neurotransmitter Release CycleCPLX1;PPFIA1;SYN3;PPFIA4;PPFIA2;SYN2;SYN1;RERG
Synaptic Vesicle PathwaySTX1B;DNM1L;SYN2;SYN1;CPLX2;SYP;PARK7;SYN3
Transmission across Chemical SynapsesSYT1A;CACFD1;ARL6IP5B;CACNB4B;ARL6IP5;PICK1;SLC6A11;BZRAP1;ARL6IP5A

SYN1 has several biochemical functions, for example, ATP binding, actin binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYN1 itself. We selected most functions SYN1 had, and list some proteins which have the same functions with SYN1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAP3K2;DDX55;CENPE;CSNK1G2A;PSMC4;MOV10B.1;TK2;HIPK1;ABCC11
actin bindingSYNE2;YWHAH;CNN1;DBNL;MYH1B;FMNL2;TPMA;MYBPC1;NRAP
calcium-dependent protein bindingANXA2;TNNI3;CHP;SYN1;RBM22;ANXA4;MMP13;S100PBP;TNNC1
catalytic activityYDJC;PKMA;HOGA1;HPGD;ACSL4A;FPGT;CWF19L1;ZRANB3;THA1
protein bindingWHSC1L1;MLC1;INPP5K;SIX4;ISOC1;TRIM13;KIF23;NEUROD1;HMGB3
protein kinase bindingPPP1R12A;PRKCZ;CEP152;AXIN1;PLK1;GHR;SLC12A5;DBF4B;AP2A2
transporter activityABCB11;SLCO1B2;RLBP1A;AQP11;FABP9;IGF2R;ABCC6;TTPA;ABCA9

SYN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYN1.

SNCA; EGFR; VIM; RB1CC1; KAT5; LUC7L3; SAP130; PSMD2; ERI1; GTF3C2; ATG4A; DGCR8; ERGIC1; ANTXR1; VPS54

Nagai, R; Hashimoto, R; et al. Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. EXPERIMENTAL CELL RESEARCH 316:2313-2321(2010).
Sun, F; Kozak, G; et al. Meiotic defects in a man with non-obstructive azoospermia: Case report. HUMAN REPRODUCTION 19:1770-1773(2004).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does SYN1 protein contribute to epilepsy? 03/05/2020

Altered expression or function of SYN1 has been linked to epilepsy, suggesting its potential role as a therapeutic target for managing seizure disorders.

Can SYN1 be a potential therapeutic target for schizophrenia? 05/21/2019

There is emerging research suggesting that SYN1 dysfunction may be associated with schizophrenia, making it a potential target for therapeutic interventions.

Can SYN1 be a target for drug development? 09/29/2018

Yes, SYN1 is considered a potential target for drug development in the context of neurological disorders to modulate neurotransmission and mitigate associated symptoms.

How is SYN1 involved in synaptic plasticity? 06/24/2017

SYN1 plays a role in synaptic plasticity by influencing the dynamic regulation of synaptic vesicles, which is crucial for learning and memory processes.

Is there a connection between SYN1 and Alzheimer's disease? 06/01/2017

Some studies suggest that alterations in SYN1 expression may contribute to synaptic dysfunction in Alzheimer's disease, making it a subject of interest for further research.

Customer Reviews (3)

Write a review
Reviews
01/16/2018

    Its purity and reliability ensure reliable and reproducible results in a variety of research applications.

    03/20/2017

      The SYN1 protein exhibits outstanding performance in enzyme-linked immunosorbent assays (ELISA).

      08/31/2016

        The protein's reliability and reproducibility in WB ensure accurate analysis of target proteins, while its suitability for electron microscopy structure analysis enables detailed examination of molecular structures.

        Ask a Question for All SYN1 Products

        Required fields are marked with *

        My Review for All SYN1 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends