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SYT2

  • Official Full Name

    synaptotagmin II

  • Overview

    Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in;the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 (PubMed 8058779)).
  • Synonyms

    SYT2; synaptotagmin II; synaptotagmin-2; Synaptotagmin 2; Synaptotagmin2; SynaptotagminII; SYT 2; Syt II; SYT2_HUMAN; SytII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SYT2-3083H Recombinant Human SYT2, GST-tagged E.coli GST 1-60aa
Human SYT2-35H Recombinant Human SYT2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SYT2-646HCL Recombinant Human SYT2 lysate HEK293 N/A
Human SYT2-1027HFL Recombinant Full Length Human SYT2 Protein, C-Flag-tagged Mammalian cells Flag
Human SYT2-2150H Recombinant Human SYT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SYT2-2150H-B Recombinant Human SYT2 Protein Pre-coupled Magnetic Beads HEK293
Human SYT2-1913H Recombinant Human SYT2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse SYT2-16334M Recombinant Mouse SYT2 Protein Mammalian Cell His
Mouse SYT2-8927M-B Recombinant Mouse SYT2 Protein Pre-coupled Magnetic Beads HEK293
Mouse SYT2-8927M Recombinant Mouse SYT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Syt2-6259M Recombinant Mouse Syt2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SYT2-5880R Recombinant Rat SYT2 Protein Mammalian Cell His
Rat SYT2-5539R Recombinant Rat SYT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SYT2-5539R-B Recombinant Rat SYT2 Protein Pre-coupled Magnetic Beads HEK293
Rat Syt2-4938R Recombinant Rat Syt2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-422aa
Mus musculus (Mouse) RFL10500MF Recombinant Full Length Mouse Synaptotagmin-2(Syt2) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Rattus norvegicus (Rat) RFL5129RF Recombinant Full Length Rat Synaptotagmin-2(Syt2) Protein, His-Tagged E.coli expression system His Full Length (1-422)
Rhesus Macaque SYT2-4590R Recombinant Rhesus monkey SYT2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SYT2-4406R-B Recombinant Rhesus Macaque SYT2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SYT2-4406R Recombinant Rhesus Macaque SYT2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SYT2 Related Articles

SYT2 involved in several pathways and played different roles in them. We selected most pathways SYT2 participated on our site, such as Disease, Infectious disease, Neurotoxicity of clostridium toxins, which may be useful for your reference. Also, other proteins which involved in the same pathway with SYT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DiseaseNMT2;TICAM1;CCNC;SSRP1;APOBEC3G;SUPT5H;STRA6;TRAT1;AP1G1
Infectious diseaseAPOBEC3G;PACS1;TAF1L;CHMP4B;SYT2;EEF2;AP1M2;IPO5;NMT1
Neurotoxicity of clostridium toxinsSYT2;STX1B
Toxicity of botulinum toxin type B (BoNT/B)
Uptake and actions of bacterial toxinsSYT2;ANTXR1;PDCD6IP;ANTXR2

SYT2 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, clathrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SYT2 itself. We selected most functions SYT2 had, and list some proteins which have the same functions with SYT2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCALR;TPO;RCN2;GUCA1E;LRP2A;PLCG1;DNASE1L3;PVALB9;PRKCSH
calcium-dependent phospholipid bindingSYTL4;SYT1;SYT11;ANXA5A;ANXA1B;SYT11A;ANXA13;SYT15;SYTL3
clathrin bindingLDLRAP1;SYT1A;CLINT1;SNAP91;PICALMB;SCLT1;HIP1;SYTL3;TOM1
inositol 1,3,4,5 tetrakisphosphate bindingITPR3;ADAP1;AKR1C1;ADAP2;SYT2
protein bindingYWHAZ;SNRPA1;MAPK9;PSAP;RPS6KA1;IGSF8;PPIC;GSTM4;ATP5A1
syntaxin bindingNAPAA;SYT4;NAPA;SYT9B;SYT11B;CPLX4A;DOC2D;SNAP23.2;PLDN

SYT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SYT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SYT2.

HTT; PAUF; TGOLN2; PRKD2

Neumann, S; Haverkamp, S; et al. Characterization of small-field bistratified amacrine cells in macaque retina labeled by antibodies against synaptotagmin-2. JOURNAL OF COMPARATIVE NEUROLOGY 521:709-724(2013).
Monterrat, C; Boal, F; et al. Synaptotagmin 8 is expressed both as a calcium-insensitive soluble and membrane protein in neurons, neuroendocrine and endocrine cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1763:73-81(2006).
HILBUSH, BS; MORGAN, JI; et al. A 3RD SYNAPTOTAGMIN GENE, SYT3, IN THE MOUSE. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91:8195-8199(1994).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
06/11/2022

    It is very stable and does not denature even at low temperatures.

    10/10/2021

      I have used these several times and their performance has been very stable and there has never been a problem.

      05/30/2021

        The labeling effect is excellent in Western blot, which can be used for fluorescence labeling.

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