SHBG
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Official Full Name
sex hormone-binding globulin
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Overview
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; SBP; Sex steroid binding protein; Sex steroid-binding protein; SHBG_HUMAN; Testis specific androgen binding protein; Testis-specific androgen-binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testosterone estrogen binding globulin; Testosterone-estradiol-binding globulin; Testosterone-estrogen-binding globulin; OTTHUMP00000135293; testosterone-binding beta-globulin;
- Native Proteins
- Recombinant Proteins
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293 cells
- HEK293F
- HEK293T
- Human pregnancy Plasma
- Human Serum
- Mammalian Cell
- Mammalian cells
- C
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SHBG Related Articles
SHBG involved in several pathways and played different roles in them. We selected most pathways SHBG participated on our site, such as Nongenotropic Androgen signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Nongenotropic Androgen signaling |
SHBG has several biochemical functions, for example, androgen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHBG itself. We selected most functions SHBG had, and list some proteins which have the same functions with SHBG. You can find most of the proteins on our site.
Function | Related Protein |
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androgen binding | Ar;SHBG;TSPO;ALDH1A1 |
SHBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHBG here. Most of them are supplied by our site. Hope this information will be useful for your research of SHBG.
GRB2; CLEC4G; d-mannose
- Q&As
- Reviews
Q&As (7)
Ask a questionSHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.
SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.
Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.
Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.
SHBG is predominantly produced in the liver.
SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.
By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.
Customer Reviews (3)
Write a reviewVery satisfied, worked perfectly.
Fast shipping, product perfect.
Excellent results in assay.
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