Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

SHBG

  • Official Full Name

    sex hormone-binding globulin

  • Overview

    This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    SHBG; sex hormone-binding globulin; ABP; androgen binding protein; MGC126834; MGC138391; TEBG; SBP; Sex steroid binding protein; Sex steroid-binding protein; SHBG_HUMAN; Testis specific androgen binding protein; Testis-specific androgen-binding protein; Testosterone binding beta globulin; Testosterone Estradiol Binding Globulin; Testosterone estrogen binding globulin; Testosterone-estradiol-binding globulin; Testosterone-estrogen-binding globulin; OTTHUMP00000135293; testosterone-binding beta-globulin;

  • Native Proteins
  • Recombinant Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human pregnancy Plasma
  • Human Serum
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SHBG-8259H Native Human Serum Sex Hormone Binding Globulin Human Serum N/A
Human SHBG-3742H Recombinant Human SHBG protein, His-tagged CHO His 428 AA
Human SHBG-505H Recombinant Human SHBG protein, His-tagged HEK293F His Pro51~Asp218
Human SHBG-504H Recombinant Human SHBG protein, His-tagged HEK293F His Gly224~His388
Human SHBG-584H Recombinant Human SHBG Protein, His-tagged E.coli His Pro51~Asp218
Human SHBG-583H Recombinant Human SHBG Protein, His-tagged E.coli His Gly224~His388
Human SHBG-0054H Recombinant Human SHBG Protein HEK293 cells
Human SHBG-5519H Native Human Sex Hormone-Binding Globulin Human pregnancy Plasma N/A
Human SHBG-182H Human Sex Hormone Binding Globulin Reference standard N/A
Human SHBG-6282H Recombinant Human SHBG Protein (Met1-His402), C-His tagged Mammalian cells C-His Met1-His402
Human SHBG-30637TH Native Human SHBG protein Human Serum N/A
Human SHBG-1228H Recombinant Human SHBG Protein, His-tagged CHO N-His Leu31-His402
Mouse SHBG-15089M Recombinant Mouse SHBG Protein Mammalian Cell His
Mouse Shbg-12M Recombinant Mouse Shbg protein, His-tagged E.coli His Asp219~Ser358
Mouse Shbg-13M Recombinant Mouse Shbg protein, His-tagged E.coli His Gly53~Ser214
Mouse SHBG-8140M Recombinant Mouse SHBG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Shbg-5853M Recombinant Mouse Shbg Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse SHBG-8140M-B Recombinant Mouse SHBG Protein Pre-coupled Magnetic Beads HEK293
Rat Shbg-50R Recombinant Rat Shbg protein, His-tagged E.coli His Pro44~Leu222
Rat SHBG-5389R Recombinant Rat SHBG Protein Mammalian Cell His
Rat Shbg-587R Recombinant Rat Shbg Protein, His-tagged E.coli His Leu222~Ser358
Rat SHBG-5048R Recombinant Rat SHBG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SHBG-5048R-B Recombinant Rat SHBG Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SHBG-1645Z Recombinant Zebrafish SHBG Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SHBG Related Articles

SHBG involved in several pathways and played different roles in them. We selected most pathways SHBG participated on our site, such as Nongenotropic Androgen signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nongenotropic Androgen signaling

SHBG has several biochemical functions, for example, androgen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHBG itself. We selected most functions SHBG had, and list some proteins which have the same functions with SHBG. You can find most of the proteins on our site.

Function Related Protein
androgen bindingAr;SHBG;TSPO;ALDH1A1

SHBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHBG here. Most of them are supplied by our site. Hope this information will be useful for your research of SHBG.

GRB2; CLEC4G; d-mannose

Chiesa, A; Olcese, MC; et al. Variable clinical presentation and outcome in pediatric patients with resistance to thyroid hormone (RTH). ENDOCRINE 41:130-137(2012).
Schmidt, J; Brannstrom, M; et al. Reproductive Hormone Levels and Anthropometry in Postmenopausal Women with Polycystic Ovary Syndrome (PCOS): A 21-Year Follow-Up Study of Women Diagnosed with PCOS around 50 Years Ago and Their Age-Matched Controls. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 96:2178-2185(2011).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does SHBG interact with other proteins and receptors in the body? 12/07/2022

SHBG interacts with cell surface receptors, influencing cellular responses to sex hormones.

How is SHBG used as a diagnostic marker in clinical settings? 08/21/2022

SHBG levels are used to assess free testosterone levels, helping diagnose hormonal imbalances.

What factors can influence the levels of SHBG in the bloodstream? 04/16/2022

Factors influencing SHBG levels include age, sex, hormonal balance, and certain medical conditions.

What are the implications of abnormally high or low levels of SHBG? 03/19/2022

Abnormally high SHBG can reduce free testosterone, potentially leading to hypogonadism, while low SHBG can increase free testosterone, possibly contributing to conditions like polycystic ovary syndrome (PCOS) and insulin resistance.

In which organs or tissues is SHBG predominantly produced? 09/06/2021

SHBG is predominantly produced in the liver.

What is the primary biological role of Sex Hormone-Binding Globulin (SHBG) in the body? 01/23/2020

SHBG binds and transports sex hormones, particularly testosterone and estradiol, in the bloodstream.

How does SHBG regulate the bioavailability of sex hormones? 01/08/2020

By binding sex hormones, SHBG controls their free, bioavailable forms and regulates their activity.

Customer Reviews (3)

Write a review
Reviews
10/27/2022

    Very satisfied, worked perfectly.

    09/15/2021

      Fast shipping, product perfect.

      04/06/2021

        Excellent results in assay.

        Ask a Question for All SHBG Products

        Required fields are marked with *

        My Review for All SHBG Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends