SOCS3
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Official Full Name
suppressor of cytokine signaling 3
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Overview
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] -
Synonyms
SOCS3; suppressor of cytokine signaling 3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Trx
- Involved Pathway
- Protein Function
- Interacting Protein
- SOCS3 Related Articles
- SOCS3 Related Signal Pathway
SOCS3 involved in several pathways and played different roles in them. We selected most pathways SOCS3 participated on our site, such as Ubiquitin mediated proteolysis, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | RHOBTB2;FBXO4;BIRC8;UBE2IA;UBE2D1B;CUL2;SOCS3;FBXW7;UBE2J1 |
| Osteoclast differentiation | FCGR1;FCGR1A;IL1R1;IKBKG;SQSTM1;MAPK8;LILRB4;TNFRSF11A;NFKBIA |
| Jak-STAT signaling pathway | CSH1;PIK3R3;IL2RGA;PRL2;IL12A;IFNB1;GHR;IRX1;CCND2A |
| TNF signaling pathway | PTGS2;AKT2;MAPK3;TNFAIP3;CREB3L1;CXCL1;SELE;CREB5;MAP2K1 |
| Insulin signaling pathway | SHC2;FOXO1B;MAPK8A;PRKCZ;MAP2K1;CALM4;INSB;RPS6KB1B;CALML3 |
| Prolactin signaling pathway | LHCGR;MAP2K1;AKT2;CSH;MAPK10;INS;PIK3CA;PIK3R2;SHC2 |
| Adipocytokine signaling pathway | MAPK8A;PPARGC1A;PPARAB;POMC;G6PC3;ACSL4;SLC2A4;TNFRSF1A;TRADD |
| Type II diabetes mellitus | MAPK1;IRS2;MTOR;HK1;PKLR;IRS1;MAPK3;MAFA;SLC2A4 |
| Insulin resistance | PTENB;PTPN11A;PPP1R3DA;CREB3L2;ACACB;NR1H2;SLC27A4;CREB3L3A;TNFRSF1A |
| Non-alcoholic fatty liver disease (NAFLD) | INS1;CDC42;AKT1;RXRA;UQCRC1;NDUFA11;TNFRSF1A;NDUFA8;COX7B2 |
| Hepatitis C | CLDN3;IFNA16;PDPK1;PPARA;IFNA21;RNASEL;PIK3R5;BAD;TLR3 |
| Influenza A | NXF1;ACTG1;NLRP3;BMA2;RNASEL;FAS;IL-8;IRAK4;RELA |
| Herpes simplex infection | SFRS3B;HLA-DQA2;PVRL1B;IFNA3;HLA-A;HLA-DMB;IL15;HNRPKL;PPP1CC |
SOCS3 has several biochemical functions, for example, protein binding, protein kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS3 itself. We selected most functions SOCS3 had, and list some proteins which have the same functions with SOCS3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TLX2;HCFC1;EIF4EBP3L;SUSD2;KLK6;Ctsl;AARSD1;VIPAS39;TMPRSS2 |
| protein kinase inhibitor activity | CAMK2N1A;CHP1;TRIB3;SOCS3;CD36;SOCS5B;NPM1;SH3BP5B;SOCS1B |
SOCS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS3.
PTK2; YES1; KIAA1958; MAP1S; TRDN; SH2D2A; RASA1
- Q&As
- Reviews
Q&As (6)
Ask a questionTherapeutic strategies for SOCS3 can include regulating its expression level, blocking its interaction with other proteins, or regulating its associated signal transduction pathways. These approaches may have potential applications in the treatment of autoimmune diseases, inflammatory diseases, and certain cancers.
The structure of SOCS3 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
In inflammatory diseases, SOCS3 may reduce the inflammatory response by inhibiting the production and release of pro-inflammatory cytokines and promoting the expression of anti-inflammatory factors. It could be a potential target for the treatment of inflammatory diseases.
This protein can interact with a variety of other proteins, including JAK kinase, STAT transcription factors, etc. These interactions enable it to regulate processes such as cell growth, differentiation, and apoptosis.
Drug development for SOCS3 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
SOCS3 is primarily involved in immunosuppressive and anti-inflammatory responses in the immune system. It can inhibit the production and release of pro-inflammatory cytokines and promote the expression of anti-inflammatory factors, thereby reducing the inflammatory response.
Customer Reviews (3)
Write a reviewSOCS3 is very stable in Western blot, and its performance will not be affected even if it is stored for a long time.
SOCS3 has long-lasting effects and sustained release performance.
This synthesis cost and application cost are moderate, and it is cost-effective for production.
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