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SRC

  • Official Full Name

    v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

  • Overview

    This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms

    SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Human
  • Mouse
  • Mus musculus
  • Rhesus Macaque
  • RSV
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • Myc|DDK
  • N/A
  • N
  • FLAG
  • No tag
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SRC-533H Active Recombinant Human SRC protein, His-tagged Insect Cell His
Human SRC-1100H Active Recombinant Human SRC protein, GST-tagged E.coli GST
Human SRC-575H Active Recombinant Human SRC, GST-tagged E.coli GST
Human SRC-1358H Active Recombinant Human SRC protein, His/GST-tagged Insect Cell His/GST
Human SRC-231H Active Recombinant Human SRC(1-530) Protein, N-His-tagged Sf21 His 1-530 aa
Human SRC-170HFL Active Recombinant Full Length Human SRC(T341M) Mutation Protein, N-His-tagged Sf21 His Full Length
Human SRC-171HFL Active Recombinant Full Length Human SRC Protein, N-His-tagged Sf21 His Full Length
Human SRC-381H Recombinant Human SRC Mammalian Cell His
Human SRC-2947H Recombinant Human SRC, GST-tagged E.coli GST C-term-350aa
Human SRC-191H Recombinant Human SRC, GST-tagged E.coli GST
Human SRC-433H Recombinant Human SRC, GST-tagged, Active Sf9 Insect Cell GST
Human SRC-22H Recombinant Human SRC protein, His-tagged E.coli His
Human SRC-192H Recombinant Human SRC, SH3 Domain, GST-tagged E.coli GST
Human SRC-79H Recombinant Human SRC protein, Flag-tagged, Biotinylated Insect Cell Flag
Human SRC-487HCL Recombinant Human SRC cell lysate Insect Cell N/A
Human SRC-2747H Recombinant Human SRC Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SRC-1923H Recombinant Human SRC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SRC-407HFL Recombinant Full Length Human SRC Protein, C-Flag-tagged Mammalian cells Flag
Human SRC-004H Active Recombinant Human SRC Protein, GST-tagged Insect cell GST 1-536
Human SRC-1750HF Active Recombinant Full Length Human SRC Protein, GST-tagged Insect (sf21) GST 1-536(end)
Human SRC-3525H Recombinant Human SRC protein, His-tagged E.coli His 2-536aa
Human SRC2592H Recombinant Human Src (255-524) Protein
Human SRC-6766HF Active Recombinant Full Length Human SRC Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-536(end)
Human SRC-29697TH Native Human SRC E.coli N/A
Human SRC-3526H Recombinant Human SRC protein E.coli N/A 2-536aa
Human SRC-10H Active Recombinant Human SRC Protein (Full Length), N-FLAG Insect Cell N-FLAG Full Length
Human SRC-6350H Recombinant Human SRC Protein (Met1-Leu536), N-His tagged E.coli N-His Met1-Leu536
Human SRC-2094H-B Recombinant Human SRC Protein Pre-coupled Magnetic Beads HEK293
Human SRC-2094H Recombinant Human SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SRC-0402H Recombinant Human SRC Protein (G2-L536), Tag Free Insect Cell No tag G2-L536
Human SRC-0403H Recombinant Human SRC Protein (G2-L536), His/Flag tagged Insect Cell His/Flag G2-L536
Human SRC-0186H Recombinant Human SRC Protein (Full Length), N-His-tagged Baculovirus-Insect cells N-His Full Length
Human SRC-6351H Recombinant Human SRC Protein (Tyr187-Leu536), N-His tagged E.coli N-His Tyr187-Leu536
Mouse Src-593M Recombinant Mouse Rous Sarcoma Oncogene, Domain E.coli N/A
Mouse Src-99M Recombinant Mouse Rous Sarcoma Oncogene, SH3 Domain E.coli N/A
Mouse Src-907M Active Recombinant Mouse Src protein(Met1-Leu535), His&GST-tagged Insect Cells N-His&GST Met1-Leu535
Mouse SRC-585MCL Recombinant Mouse SRC cell lysate Insect Cell N/A
Mouse Src-6122M Recombinant Mouse Src Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mus musculus Src-1367M Recombinant Mus musculus Src Protein (V85-L535), His-tagged Insect Cell His V85-L535
Mus musculus Src-1368M Recombinant Mus musculus Src Protein (V85-L535) Insect Cell Tag Free V85-L535
Rhesus Macaque SRC-4460R Recombinant Rhesus monkey SRC Protein, His-tagged Mammalian Cell His
Rhesus Macaque SRC-4276R-B Recombinant Rhesus Macaque SRC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SRC-4276R Recombinant Rhesus Macaque SRC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
RSV Src-546R Active Recombinant RSV Src, GST-tagged Sf9 Insect Cell GST
Zebrafish SRC-1128Z Recombinant Zebrafish SRC Mammalian Cell His
Chicken SRC-7007C Recombinant Chicken SRC Mammalian Cell His
Kit-0800 c-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SRC Related Articles
  • SRC Related Gene Family
  • SRC Related Research Area
  • SRC Related Signal Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayGRB2;CAMK2D2;MAPK8B;MAP2K4;ERBB3;KRAS;MAP2K1;PIK3CG;PAK2
Rap signaling pathwayNRAS;GNAI1;RAPGEF6;CALM3;ARAP3;VEGFA;SRC;VEGFB;CALM1
Chemokine signaling pathwayCCL3;CCL22;CCL7;NFKBIB;CCL13;PIK3CG;CXCL1;CCR9;CCL4
EndocytosisSNX4;HSPA8;SH3GL1;STAMBP;CDC42;SPG21;CYTH4;RHOAB;TGFBR1B
VEGF signaling pathwayMAP2K2B;NRAS;PPP3R1B;CASP9;PXN;SH2D2A;PPP3CC;PRKCBA;PTK2AB
Focal adhesionPAK4;KDRL;ITGA7;IGF1RB;VTNB;CDC42L;ITGA6B;VEGFA;SHC3
Adherens junctionACTN3A;WASLB;PTPN1;RAC1B;FARP2;FGFR1;CTNNA2;EGFR;PTPRF
Tight junctionPRKCH;MYL12.2;MYH11A;MYL7;CLDN5B;MYH15;RAB13;ACTG1;TJP2
Gap junctionPDGFAA;TUBA8L;TUBB2B;HRASB;TUBA1L;CDK1;ITPR1;TUBB2A;PDGFRB
Platelet activationPIK3R5;NOS3;PIK3CB;ARHGEF12;P2RY12;PLCB1;GNAI1;F2RL3;MAPK12
GABAergic synapseGNAO1;GNB4;GABBR1;SLC38A5;GABRA1;GNG5;GNB1;PRKACB;GNG10
Inflammatory mediator regulation of TRP channelsIL1B;PTGER2;CYP2C50;NGF;BDKRB2;TRPV3;PRKCD;CYP2C54;CYP2C39
Regulation of actin cytoskeletonPPP1CBL;ARHGAP35;WASLB;FGF13;FGF20B;ARHGEF6;BDKRB2;ITGA3B;DIAPH1
GnRH signaling pathwayMAP2K6;PLCB1;GNAS;FSHB;ATF4;CAMK2B;ATF4B1;GNA15.1;CALM1B
Estrogen signaling pathwayGNAI1;GNAI3;SHC2;GNAI2;GABBR1;HSPA6;SHC3;KCNJ3;HSPA1A
Prolactin signaling pathwayNFKB1;MAPK12;SOCS2;STAT5B;PIK3R2;SOCS7;KRAS;CSH;SOCS4
Thyroid hormone signaling pathwayTBC1D4;PIK3R2;GATA4;MED14;MAP2K1;DIO3;ACTB;PRKCG;PRKACB
Oxytocin signaling pathwayELK1;RYR1;CALM4;MAPK1;PIK3R5;PLCB3;CALM2;PIK3CA;PRKAG2
Bacterial invasion of epithelial cellsSEPT1;CTNNA1;DNM1;SEPT2;ITGB1;SEPT11;FN1;CBLC;BCAR1
Epithelial cell signaling in Helicobacter pylori infectionATP6V1G2;ATP6V1D;CXCL1;ATP6V0A4;PAK1;ATP6V1B1;ATP6V1C2;RAC1;JAM2
ShigellosisUBE2D2;RELA;DIAPH1;HCLS1;ELMO1;FBXW11;MAPK10;BTRC;RIPK2
TuberculosisSPHK1;TLR4;PPP3R1;CAP18;IFNA7;IFNGR2;IRAK2;HLA-DQA1;HLA-DRA
Hepatitis BNFATC2;MMP9;PRKCA;IFNAR1;TLR3;PCNA;PIK3CA;IFNA13;EGR3
Viral carcinogenesisSTAT5A;UBR4;HLA-B;KRAS;MDM2;STAT3;PKM;HIST2H2BE;UBE3A
Proteoglycans in cancerMMP9;RRAS;AKT2;CD63;GPC3;MAPK13;FAS;SDC1;FLNC
Bladder cancerDAPK1;MMP1A;TP53;MAPK3;DAPK3;HBEGF;E2F2;E2F3;MMP1

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.

Function Related Protein
ATP bindingP2RX1;NSFB;OAS1;MAP3K3;ATP1A4;P2RY1;TLK2;DSTYK;TRIT1
SH2 domain bindingJAK2;AFAP1L2;SRC;SYP;ARHGAP5;SH3PXD2B;NLK;PAG1;CRK
SH3/SH2 adaptor activityCHN2;KHDRBS1;SH2B2;LASP1;GRB10;SH3BP2;CRK;NCK2;ITSN2
enzyme bindingZNHIT6;CLSTN2;HAND1;PICK1;N4BP2L2;CCND1;HDAC6;NFKBIA;SNX12
ephrin receptor bindingEFNB2B;EFNB2A;PTPN1;SIPA1L1;EFNA4;EFNA5B;NTRK1;EFNB2;CHN1
growth factor receptor bindingFYN;APP;SLC9A3R1;SRC
heme bindingBACH1;PTGES2;SUOX;PGRMC1;CYP2AA3;NENF;CYP4A10;CYP1A;HBBE3
hormone receptor bindingTNK2B;SRC;TNK2;TNK1;JAK2B;JAK3;JAK2A
integrin bindingICAM3;IGF1;NF2;ADAM22;CTGFB;THBS4;COL5A1;ACTN2;WISP1A
ion channel bindingPPP1R9B;KCNE2;YWHAQ;HSP90AB1;HTT;DLG1;LYN;FGF13;FHL1
kinase activitySGMS2;PRKCBB;DCLK2;MAP3K12;PI4KAB;NEK5;PI4KAA;CDK5;PINK1
kinase bindingPFKM;DGKQ;STRADA;CHP;C2orf44;DLG1;CEBPB;TOLLIP;WWC1
non-membrane spanning protein tyrosine kinase activityJAK1;DYRK1A;TYK2;SRMS;RIPK2;FRK;HCK;PTK2;JAK2B
phosphoprotein bindingPAFAH1B1;SAG;YWHAB;MTOR;RRAGA;MID2;CACNB2;YWHAE;SERPINB1A
protein bindingHM13;ENDOG;RPS15;PALB2;FCNA;MAP1S;TELO2;SPOP;FAM168A
protein kinase activityMMD;RASSF2;RPS6KA6;RPS6KAL;OXSR1A;NLK1;SGK2B;IKBKB;TESK2
protein tyrosine kinase activityJAK2;INSR;RET;TTN;MAP2K3;ZAP70;JAK2A;DYRK3;TNK2B
receptor bindingGFRA1;HAND2;SERPINE1;NPPB;FGF10A;REN;CNTFR;GBA;IAPP
scaffold protein bindingMAP2K2;KCNA5;CACNA1G;KCNH2;NOS3;NLGN4Y;SRC;CAV2;NLGN4X

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.

PTPN1; PTK2

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).
  • Q&As
  • Reviews

Q&As (7)

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How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

Customer Reviews (3)

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Reviews
01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

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