SRC
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Official Full Name
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
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Overview
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Human
- Mouse
- Mus musculus
- Rhesus Macaque
- RSV
- Zebrafish
- Baculovirus-Insect cells
- E.coli
- HEK293
- HEK293T
- Insect (sf21)
- Insect cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- Myc|DDK
- N/A
- N
- FLAG
- No tag
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- SRC Related Articles
- SRC Related Gene Family
- SRC Related Research Area
- SRC Related Signal Pathway
SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ErbB signaling pathway | GRB2;CAMK2D2;MAPK8B;MAP2K4;ERBB3;KRAS;MAP2K1;PIK3CG;PAK2 |
Rap signaling pathway | NRAS;GNAI1;RAPGEF6;CALM3;ARAP3;VEGFA;SRC;VEGFB;CALM1 |
Chemokine signaling pathway | CCL3;CCL22;CCL7;NFKBIB;CCL13;PIK3CG;CXCL1;CCR9;CCL4 |
Endocytosis | SNX4;HSPA8;SH3GL1;STAMBP;CDC42;SPG21;CYTH4;RHOAB;TGFBR1B |
VEGF signaling pathway | MAP2K2B;NRAS;PPP3R1B;CASP9;PXN;SH2D2A;PPP3CC;PRKCBA;PTK2AB |
Focal adhesion | PAK4;KDRL;ITGA7;IGF1RB;VTNB;CDC42L;ITGA6B;VEGFA;SHC3 |
Adherens junction | ACTN3A;WASLB;PTPN1;RAC1B;FARP2;FGFR1;CTNNA2;EGFR;PTPRF |
Tight junction | PRKCH;MYL12.2;MYH11A;MYL7;CLDN5B;MYH15;RAB13;ACTG1;TJP2 |
Gap junction | PDGFAA;TUBA8L;TUBB2B;HRASB;TUBA1L;CDK1;ITPR1;TUBB2A;PDGFRB |
Platelet activation | PIK3R5;NOS3;PIK3CB;ARHGEF12;P2RY12;PLCB1;GNAI1;F2RL3;MAPK12 |
GABAergic synapse | GNAO1;GNB4;GABBR1;SLC38A5;GABRA1;GNG5;GNB1;PRKACB;GNG10 |
Inflammatory mediator regulation of TRP channels | IL1B;PTGER2;CYP2C50;NGF;BDKRB2;TRPV3;PRKCD;CYP2C54;CYP2C39 |
Regulation of actin cytoskeleton | PPP1CBL;ARHGAP35;WASLB;FGF13;FGF20B;ARHGEF6;BDKRB2;ITGA3B;DIAPH1 |
GnRH signaling pathway | MAP2K6;PLCB1;GNAS;FSHB;ATF4;CAMK2B;ATF4B1;GNA15.1;CALM1B |
Estrogen signaling pathway | GNAI1;GNAI3;SHC2;GNAI2;GABBR1;HSPA6;SHC3;KCNJ3;HSPA1A |
Prolactin signaling pathway | NFKB1;MAPK12;SOCS2;STAT5B;PIK3R2;SOCS7;KRAS;CSH;SOCS4 |
Thyroid hormone signaling pathway | TBC1D4;PIK3R2;GATA4;MED14;MAP2K1;DIO3;ACTB;PRKCG;PRKACB |
Oxytocin signaling pathway | ELK1;RYR1;CALM4;MAPK1;PIK3R5;PLCB3;CALM2;PIK3CA;PRKAG2 |
Bacterial invasion of epithelial cells | SEPT1;CTNNA1;DNM1;SEPT2;ITGB1;SEPT11;FN1;CBLC;BCAR1 |
Epithelial cell signaling in Helicobacter pylori infection | ATP6V1G2;ATP6V1D;CXCL1;ATP6V0A4;PAK1;ATP6V1B1;ATP6V1C2;RAC1;JAM2 |
Shigellosis | UBE2D2;RELA;DIAPH1;HCLS1;ELMO1;FBXW11;MAPK10;BTRC;RIPK2 |
Tuberculosis | SPHK1;TLR4;PPP3R1;CAP18;IFNA7;IFNGR2;IRAK2;HLA-DQA1;HLA-DRA |
Hepatitis B | NFATC2;MMP9;PRKCA;IFNAR1;TLR3;PCNA;PIK3CA;IFNA13;EGR3 |
Viral carcinogenesis | STAT5A;UBR4;HLA-B;KRAS;MDM2;STAT3;PKM;HIST2H2BE;UBE3A |
Proteoglycans in cancer | MMP9;RRAS;AKT2;CD63;GPC3;MAPK13;FAS;SDC1;FLNC |
Bladder cancer | DAPK1;MMP1A;TP53;MAPK3;DAPK3;HBEGF;E2F2;E2F3;MMP1 |
SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | P2RX1;NSFB;OAS1;MAP3K3;ATP1A4;P2RY1;TLK2;DSTYK;TRIT1 |
SH2 domain binding | JAK2;AFAP1L2;SRC;SYP;ARHGAP5;SH3PXD2B;NLK;PAG1;CRK |
SH3/SH2 adaptor activity | CHN2;KHDRBS1;SH2B2;LASP1;GRB10;SH3BP2;CRK;NCK2;ITSN2 |
enzyme binding | ZNHIT6;CLSTN2;HAND1;PICK1;N4BP2L2;CCND1;HDAC6;NFKBIA;SNX12 |
ephrin receptor binding | EFNB2B;EFNB2A;PTPN1;SIPA1L1;EFNA4;EFNA5B;NTRK1;EFNB2;CHN1 |
growth factor receptor binding | FYN;APP;SLC9A3R1;SRC |
heme binding | BACH1;PTGES2;SUOX;PGRMC1;CYP2AA3;NENF;CYP4A10;CYP1A;HBBE3 |
hormone receptor binding | TNK2B;SRC;TNK2;TNK1;JAK2B;JAK3;JAK2A |
integrin binding | ICAM3;IGF1;NF2;ADAM22;CTGFB;THBS4;COL5A1;ACTN2;WISP1A |
ion channel binding | PPP1R9B;KCNE2;YWHAQ;HSP90AB1;HTT;DLG1;LYN;FGF13;FHL1 |
kinase activity | SGMS2;PRKCBB;DCLK2;MAP3K12;PI4KAB;NEK5;PI4KAA;CDK5;PINK1 |
kinase binding | PFKM;DGKQ;STRADA;CHP;C2orf44;DLG1;CEBPB;TOLLIP;WWC1 |
non-membrane spanning protein tyrosine kinase activity | JAK1;DYRK1A;TYK2;SRMS;RIPK2;FRK;HCK;PTK2;JAK2B |
phosphoprotein binding | PAFAH1B1;SAG;YWHAB;MTOR;RRAGA;MID2;CACNB2;YWHAE;SERPINB1A |
protein binding | HM13;ENDOG;RPS15;PALB2;FCNA;MAP1S;TELO2;SPOP;FAM168A |
protein kinase activity | MMD;RASSF2;RPS6KA6;RPS6KAL;OXSR1A;NLK1;SGK2B;IKBKB;TESK2 |
protein tyrosine kinase activity | JAK2;INSR;RET;TTN;MAP2K3;ZAP70;JAK2A;DYRK3;TNK2B |
receptor binding | GFRA1;HAND2;SERPINE1;NPPB;FGF10A;REN;CNTFR;GBA;IAPP |
scaffold protein binding | MAP2K2;KCNA5;CACNA1G;KCNH2;NOS3;NLGN4Y;SRC;CAV2;NLGN4X |
SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.
PTPN1; PTK2
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Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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