Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ARSH

  • Official Full Name

    arylsulfatase family, member H

  • Overview

    Sulfatases, such as ARSH, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and;glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of;macromolecules (Sardiello et al., 2005 (PubMed 16174644)).
  • Synonyms

    ARSH; arylsulfatase family, member H; arylsulfatase H; ASH; sulfatase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • E.coli expression system
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ARSH-866H Recombinant Human ARSH protein, GST-tagged Wheat Germ GST
Human ARSH-133HCL Recombinant Human ARSH cell lysate N/A
Human ARSH-1306HF Recombinant Full Length Human ARSH Protein, GST-tagged In Vitro Cell Free System GST 562 amino acids
Canis lupus familiaris (Dog) (Canis familiaris) RFL21913CF Recombinant Full Length Dog Arylsulfatase H(Arsh) Protein, His-Tagged E.coli expression system His Full Length (1-562)
Homo sapiens (Human) RFL23275HF Recombinant Full Length Human Arylsulfatase H(Arsh) Protein, His-Tagged E.coli expression system His Full Length (1-562)
Chicken ARSH-5942C Recombinant Chicken ARSH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ARSH involved in several pathways and played different roles in them. We selected most pathways ARSH participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Glycosphingolipid metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARSH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activationDOHH;ARSJ;PROZ;DPH3;F9B;ARSK;DNAJC24;OTOP2;FURINA
Glycosphingolipid metabolismGLB1L;GLTPD1;ARSI;ARSD;ARSJ;CPTP;NEU3;NEU4;GLTPA
MetabolismCOX6B1;NDUFAF3;CYP27B1;GLTPA;ABHD3;TM9SF1;SLC2A3;NUDT4B;ACY3.2
Metabolism of lipids and lipoproteinsFABP11A;ABHD3;MTP;CPNE7;SUMF2;SLC27A5;ACOT2;ACSF2;PPM1L
Metabolism of proteinsB3GNT3;KIFC3;ST8SIA3;VBP1;PMPCB;IGF2B;ADAMTS8;ARSF;EXOC3
Post-translational protein modificationTMED10;ADAMTS4;ATPBD4;TMED2;SMC6;NAPB;MGAT4B;STT3A;CBX4
Sphingolipid metabolismKDSR;PPAP2B;PPM1LA;CERS4A;OSBP;GALC;NEU3.5;PPAP2C;LASS1
The activation of arylsulfatasesARSJ;ARSK;SUMF2;ARSF;ARSI;ARSH

ARSH has several biochemical functions, for example, arylsulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARSH itself. We selected most functions ARSH had, and list some proteins which have the same functions with ARSH. You can find most of the proteins on our site.

Function Related Protein
arylsulfatase activityARSF;ARSA;ARSG;ARSK;ARSD;ARSI;SULF2;ARSB;ARSE
metal ion bindingSIVA1;ZNF800;HDHD1A;YY1A;ASAP2B;SALL3B;ATP1A3;PCXA;NUFIP1

ARSH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARSH here. Most of them are supplied by our site. Hope this information will be useful for your research of ARSH.

  • Q&As
  • Reviews

Q&As (10)

Ask a question
Are there any known ARSH protein interactors? 06/20/2022

While the precise protein interactors of ARSH are not extensively studied, it is hypothesized to interact with other proteins involved in the same metabolic pathways or cellular processes. Further research is necessary to identify specific interactors.

Are there any diseases or disorders associated with mutations in the ARSH gene? 05/14/2022

Yes, mutations in the ARSH gene have been linked to X-linked ichthyosis, a genetic disorder characterized by dry, scaly skin.

How is the activity of the ARSH protein regulated? 01/23/2022

The activity of the ARSH protein can be regulated at the transcriptional level by factors that control the expression of the ARSH gene. Additionally, post-translational modifications or interactions with other proteins can also modulate its activity.

Can alterations in ARSH activity contribute to the development of certain diseases? 10/18/2020

Yes, alterations in ARSH activity, either through genetic mutations or other regulatory mechanisms, can contribute to the development of diseases related to sulfated steroid metabolism, such as X-linked ichthyosis or disorders involving hormone imbalances.

How does the ARSH protein hydrolyze sulfate esters? 07/27/2019

The ARSH protein utilizes a catalytic mechanism called nucleophilic attack to break the ester bond in sulfate esters. It involves the formation of an enzyme-substrate complex and the transfer of a hydroxyl ion to the ester group, resulting in the hydrolysis of the ester.

Are there any ongoing studies or research focusing on the ARSH protein? 06/09/2018

Research and studies are ongoing to further understand the role of ARSH in sulfated steroid metabolism, its regulation, and potential implications in health and disease. Scientists are exploring its therapeutic potential and investigating factors that may modulate its activity.

Can changes in ARSH activity affect cellular physiology? 11/17/2017

Yes, changes in ARSH activity can disrupt the metabolism and signaling of sulfated steroids. This can have implications for various physiological processes, including hormone regulation and lipid metabolism.

Is ARSH expression regulated in different tissues or during development? 03/11/2017

Yes, ARSH expression can vary in different tissues and can be regulated during different stages of development. This tissue-specific expression allows for the efficient control and modulation of sulfated steroid metabolism in specific cellular contexts.

Are there any known drugs or compounds that modulate ARSH activity? 04/22/2016

Currently, there are no specific drugs or compounds known to directly modulate ARSH activity. However, understanding its function and regulation may provide potential targets for therapeutic interventions in the future.

What happens when there are mutations in the ARSH gene? 01/21/2016

Mutations in the ARSH gene can lead to the production of a dysfunctional or non-functional ARSH protein. This can impair the hydrolysis of sulfate esters, disrupting the normal metabolism of sulfated steroids and potentially causing health conditions like X-linked ichthyosis.

Customer Reviews (3)

Write a review
Reviews
03/12/2023

    In addition to its outstanding quality, the manufacturer of the ARSH protein offers excellent technical support that can effectively address any challenges I may encounter.

    12/13/2022

      Its impeccable purity and stability ensure accurate and reproducible results, giving me confidence in the reliability of my research outcomes

      02/06/2019

        Their dedicated team of experts is readily available to provide guidance and assistance, ensuring a seamless integration of the ARSH protein into my experimental setup.

        Ask a Question for All ARSH Products

        Required fields are marked with *

        My Review for All ARSH Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends