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TADA2A

  • Official Full Name

    transcriptional adaptor 2A

  • Overview

    Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
  • Synonyms

    ADA2; ADA2A; KL04P; hADA2; TADA2L; FLJ12705; transcriptional adapter 2-alpha; ADA2-like protein; OTTHUMP00000164062; OTTHUMP00000164063; transcriptional adaptor 2 alpha; TADA2A; transcriptional adaptor 2A;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TADA2A-1280HCL Recombinant Human TADA2A 293 Cell Lysate HEK293 N/A
Human TADA2A-1281HCL Recombinant Human TADA2A 293 Cell Lysate HEK293 N/A
Human TADA2A-126H Recombinant Human TADA2A Protein, His-tagged E.coli His
Mouse TADA2A-16381M Recombinant Mouse TADA2A Protein Mammalian Cell His
Mouse TADA2A-8961M-B Recombinant Mouse TADA2A Protein Pre-coupled Magnetic Beads HEK293
Mouse TADA2A-8961M Recombinant Mouse TADA2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TADA2A-5910R Recombinant Rat TADA2A Protein Mammalian Cell His
Rat TADA2A-5569R Recombinant Rat TADA2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TADA2A-5569R-B Recombinant Rat TADA2A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TADA2A-4603Z Recombinant Zebrafish TADA2A Mammalian Cell His
Chicken TADA2A-2035C Recombinant Chicken TADA2A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TADA2A Related Articles

TADA2A involved in several pathways and played different roles in them. We selected most pathways TADA2A participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with TADA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesPHF21A;ARID2;USP22;JMJD6;ATF7IP;SMARCC2;COPRS;SAP130;SMARCA4
Chromatin organizationC17orf81;MTA3;PHF21A;ASH2L;KDM5B;DPY30;GATAD2A;ING5B;SMARCD3
HATs acetylate histonesPHF15;ENY2;BRPF3;KAT7B;EPC1;SAP130;KAT7;ING4;PAX3A

TADA2A has several biochemical functions, for example, DNA binding, chromatin binding, contributes_to histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TADA2A itself. We selected most functions TADA2A had, and list some proteins which have the same functions with TADA2A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPOLG;ZBED1;ZFP653;OTUD7A;RPAP1;ATF4;POLR2F;MEIS1B;ARID5A
chromatin bindingSIRT2;SMC1AL;KLHDC3;LHX2;RFX4;LDB1;TOP2B;CBX7;RING1
contributes_to histone acetyltransferase activityTADA2B;TAF6L;TAF5L;TADA3;SUPT7L;TADA2A;KAT2A;SAP130;TAF9
protein bindingLARP2;RELL2;TACR2;SPG11;GNB5;NRBP1;COX8A;IL17F;FCN1
transcription coactivator activityRNF4;SUB1B;SETD3;MAML2;VGLL2;CITED2;GATA4;WWC1;MAGED1
transcription cofactor activityMAP3K7;NFKBIZ;IRF3;CREB1;ZNF763;MSX2;THRAP3;NRG1;TRIP13
transcription factor activity, sequence-specific DNA bindingHOXA13;SOX13;CBFB;CREBL2;SHOX;ZNF550;ZNF23;EGR4;TRP53
zinc ion bindingPRDM2;FHL2A;ZDHHC8B;TRIM33;ZCCHC4;ERI2;TRIM39;ZDHHC18;BTR30

TADA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TADA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TADA2A.

PRPF31; EIF4E2; MTX2; FARS2; MFAP1; MAGOH; SF3A3

Martin, M; Geudens, I; et al. PP2A regulatory subunit B alpha controls endothelial contractility and vessel lumen integrity via regulation of HDAC7. EMBO JOURNAL 32:2491-2503(2013).
Zhang, J; Wang, S; et al. Herpes simplex virus 1 DNA polymerase processivity factor UL42 inhibits TNF-alpha-induced NF-kappa B activation by interacting with p65/RelA and p50/NF-kappa B1. MEDICAL MICROBIOLOGY AND IMMUNOLOGY 202:313-325(2013).
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