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TAL2

Official Full Name

T-cell acute lymphocytic leukemia 2
Overview

This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia.
Synonyms

TAL2; T-cell acute lymphocytic leukemia 2; T-cell acute lymphocytic leukemia protein 2; bHLHa19; Class A basic helix-loop-helix protein 19; T cell acute lymphocytic leukemia 2; T cell acute lymphocytic leukemia protein 2; TAL 2; TAL-2; TAL2_HUMAN; OTTHUMP00000021840;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TAL2-1258HCL	Recombinant Human TAL2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	TAL2-5159H	Recombinant Human TAL2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Tal2-6287M	Recombinant Mouse Tal2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Rhesus Macaque	TAL2-4614R	Recombinant Rhesus monkey TAL2 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	TAL2-4430R-B	Recombinant Rhesus Macaque TAL2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	TAL2-4430R	Recombinant Rhesus Macaque TAL2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	TAL2-11484Z	Recombinant Zebrafish TAL2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAL2 Related Articles

TAL2 involved in several pathways and played different roles in them. We selected most pathways TAL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TAL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TAL2 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAL2 itself. We selected most functions TAL2 had, and list some proteins which have the same functions with TAL2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZFP689;C19orf40;ZNF469;HIST1H2AN;LYL1;IGHMBP2;ZNF692;NR5A1A;SNAPC4
RNA polymerase II regulatory region sequence-specific DNA binding	ZFY2;TRPS1;ATF4B2;H2AFY2;E4F1;NR1D1;ZGLP1;ZNF549;ZBTB4
RNA polymerase II transcription factor activity, sequence-specific DNA binding	TFAP2E;FOXC1;FOXR1;ETV4;TFDP1;FOXA2;RUNX3;SPI1A;FOXG1C
protein binding	TOR1A;BET1;RABGEF1;TAF1B;VPS24;GTF3C6;SDC2;PLSCR4;CUL5
protein dimerization activity	HER4.2;DAO;SREBF2;MEF2D;EPAS1B;ASCL1B;MNT;OLIG1;FBXW11B

TAL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAL2.

TCF4

Lee, J; Su, EW; et al. Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways. MOLECULAR AND CELLULAR BIOLOGY 31:3963-3974(2011).

Bamberger, M; Santos, AM; et al. A New Pathway of CD5 Glycoprotein-mediated T Cell Inhibition Dependent on Inhibitory Phosphorylation of Fyn Kinase. JOURNAL OF BIOLOGICAL CHEMISTRY 286:30324-30336(2011).