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TAS1R1

Official Full Name

taste receptor, type 1, member 1
Overview

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

TAS1R1; taste receptor, type 1, member 1; G protein coupled receptor 70 , GPR70; taste receptor type 1 member 1; T1R1; TR1; G protein coupled receptor 70; gm 148; gm148; GPR 70; GPR70; Krueppel related zinc finger protein 3 (HKR3 protein); Sweet taste receptor T1r; TAS1 R1; TR 1; G protein-coupled receptor 70; G-protein coupled receptor 70; seven transmembrane helix receptor;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
MYC
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TAS1R1-1249HCL	Recombinant Human TAS1R1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TAS1R1-2862H	Recombinant Human TAS1R1 protein, His-tagged	E.coli	His	22-167 aa	$319 / 25ug
Human	TAS1R1-1956H	Recombinant Human TAS1R1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Tas1r1-465M	Recombinant Mouse Tas1r1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	Tas1r1-2114M	Recombinant Mouse Tas1r1 Protein, His-tagged	E.coli	N-His	Trp20-Gln258	Inquiry
Rat	TAS1R1-5931R	Recombinant Rat TAS1R1 Protein	Mammalian Cell	His		Inquiry
Rat	TAS1R1-5590R	Recombinant Rat TAS1R1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TAS1R1-5590R-B	Recombinant Rat TAS1R1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TAS1R1-3622Z	Recombinant Zebrafish TAS1R1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TAS1R1 Related Articles

TAS1R1 involved in several pathways and played different roles in them. We selected most pathways TAS1R1 participated on our site, such as Taste transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAS1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Taste transduction	TAS2R126;ALPHA-ENAC;TAS2R108;TAS2R109;ITPR3;TAS2R144;TAS2R103;GNB3;PDE1A

TAS1R1 has several biochemical functions, for example, protein heterodimerization activity, taste receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAS1R1 itself. We selected most functions TAS1R1 had, and list some proteins which have the same functions with TAS1R1. You can find most of the proteins on our site.

Function	Related Protein
protein heterodimerization activity	ALG2;BCL2;HIST1H4E;SFRP5;MYO5A;UGT1A6;JAM3;PDGFB;PRPH
taste receptor activity	O3far1;TAS2R137;TAS2R13;TAS2R134;TAS2R140;TAS2R136;TAS1R1;TAS2R7;TAS2R3

TAS1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAS1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAS1R1.

Liu, GJ; Walter, L; et al. Differentiated adaptive evolution, episodic relaxation of selective constraints, and pseudogenization of umami and sweet taste genes TAS1Rs in catarrhine primates. FRONTIERS IN ZOOLOGY 11:-(2014).

Tornwall, O; Silventoinen, K; et al. Identifying flavor preference subgroups. Genetic basis and related eating behavior traits. APPETITE 75:1-10(2014).