Background
Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the;GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM;609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family;(Ishibashi et al., 2009 (PubMed 19077034)).