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TBCE
Official Full Name
tubulin-specific chaperone E
Background
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.
Synonyms
TBCE; tubulin-specific chaperone E; tubulin-folding cofactor E; progressive motor neuropathy; pmn; 2610206D02Rik; C530005D02Rik