TBX5
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Official Full Name
T-box 5
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Overview
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the;T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is;closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein;may play a role in heart development and specification of limb identity. Mutations in this gene have been associated;with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants;encoding different isoforms have been described for this gene. -
Synonyms
TBX5; T-box 5; HOS; T-box transcription factor TBX5; Holt Oram syndrome; T box 5; T box protein 5; T box transcription factor TBX 5; T box transcription factor TBX5; T-box protein 5; TBX 5; TBX5_HUMAN; Transcription factor T box 5; OTTHUMP00000232132; OTTHUMP00000232133; OTTHUMP00000232134; OTTHUMP00000232135;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TBX5 Related Articles
- TBX5 Related Research Area
TBX5 involved in several pathways and played different roles in them. We selected most pathways TBX5 participated on our site, such as Cardiac Progenitor Differentiation, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cardiac Progenitor Differentiation | LIN28A;T;TBX20;IRX4;BMP1;SOX1;SIRPA;ZFP42;LIN28B |
Gene Expression | ZNF37A;ZNF680;PTRFB;SKI;TSEN54;ZNF529;EIF3K;MED6;CRCP |
Generic Transcription Pathway | ZNF738;NR2E3;ZNF839;ZNF167;NR2C2AP;ZNF92;ZNF559;NR1H3;MED25 |
Heart Development | HEY2;BMP10;IRX4;TBX5;TBX20;NKX2;SMYD1;FOXC1;GATA6 |
YAP1- and WWTR1 (TAZ)-stimulated gene expression | HIPK1;TBX5;TEAD1A;NKX2;TEAD3B;TBX5A |
TBX5 has several biochemical functions, for example, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX5 itself. We selected most functions TBX5 had, and list some proteins which have the same functions with TBX5. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF74;ZFY1;MCM9;ZNF131;HOXB13A;ZFPM2;NKX6.2;ESR2B;TLR8 |
RNA polymerase II regulatory region sequence-specific DNA binding | GATA1A;SP1;CEBPB;TFAP2C;FOXC1;ZNF583;EGR1;ATF3;NME2 |
protein binding | NEK11;PHOSPHO2;FAM46C;FOXRED2;NOV;SLC35A2;RUNX1T1;KLHDC4;ITGB2 |
sequence-specific DNA binding | HOXB10A;GRHL2A;POU3F1;Trl;SOX13;CSRNP3;FOXD4;ZNF263;CALCOCO1 |
transcription factor activity, sequence-specific DNA binding | SOX4;TADA2A;WT1B;MAX;RAI1;LHX1;ZKSCAN4;GLIS2;PTF1A |
transcription factor binding | ZBTB49;HTT;ARHGEF2;INSIG2;WWP2;HDAC3;KCTD1;ADD1;DR1 |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | CREB3L4;CTCF;PKNOX1;HSF2;CREB3L3;RFX6;DLX2;PAX9;MAFF |
TBX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX5.
YAP1; tbe_human-dna; CTNNB1; Nkx2-5; Ctnnb1; Gata4; Wwtr1
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