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TCEB2

Official Full Name

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
Overview

This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Synonyms

TCEB2; transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B); transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B); transcription elongation factor B polypeptide 2; SIII; EloB; ELOB_HUMAN; Elongin 18 kDa subunit; Elongin B; Elongin-B; RNA polymerase II transcription factor SIII subunit B; SIII p18; TCEB 2; Transcription elongation factor B (SIII) polypeptide 2; OTTHUMP00000205114; OTTHUMP00000205115; OTTHUMP00000205116; elongin, 18-kD subunit; RNA polymerase II transcription;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TCEB2-30816TH	Recombinant Human TCEB2	E.coli	N/A	118 amino acids	Inquiry
Human	TCEB2-3154H	Recombinant Human TCEB2, GST-tagged	E.coli	GST	1-118aa	$319 / 25ug
Human	TCEB2-360H	Recombinant Human TCEB2 protein	E. coli	N/A	1-118 aa	Inquiry
Human	TCEB2-1187HCL	Recombinant Human TCEB2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TCEB2-1188HCL	Recombinant Human TCEB2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TCEB2-3078H	Recombinant Human TCEB2 protein, His-tagged	E.coli	His	1-118 aa	$319 / 25ug
Mouse	TCEB2-16551M	Recombinant Mouse TCEB2 Protein	Mammalian Cell	His		Inquiry
Mouse	TCEB2-9075M	Recombinant Mouse TCEB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TCEB2-9075M-B	Recombinant Mouse TCEB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	TCEB2-5987R	Recombinant Rat TCEB2 Protein	Mammalian Cell	His		Inquiry
Rat	TCEB2-5646R	Recombinant Rat TCEB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	TCEB2-5646R-B	Recombinant Rat TCEB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TCEB2-7253Z	Recombinant Zebrafish TCEB2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TCEB2 Related Articles

TCEB2 involved in several pathways and played different roles in them. We selected most pathways TCEB2 participated on our site, such as HIF- signaling pathway, Ubiquitin mediated proteolysis, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCEB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
HIF- signaling pathway	PRKCG;PLCG2;IGF1R;RPS6;PFKFB3;MAP2K1;IFNG;ANGPT2;PIK3CG
Ubiquitin mediated proteolysis	TRAF6;SIAH1A;RBX1;SIAH2L;PRP19;ITCHA;CUL3B;UBE2J1;SOCS1
Pathways in cancer	PTGER4;DAPK1;ZBTB16;GNG11;NFKBIA;CKS2;LAMA1;PDGFRA;MDM2
Renal cell carcinoma	PIK3R1;RAC1;TCEB2;EGLN1;PIK3R2;TCEB1;GAB1;MET;PIK3R5

TCEB2 has several biochemical functions, for example, protein binding, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCEB2 itself. We selected most functions TCEB2 had, and list some proteins which have the same functions with TCEB2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	NOP56;AREG;TULP3;SPACA3;HARS2;NDNL2;ARHGEF1;UTP14A;PRKCD
ubiquitin protein ligase binding	YOD1;NFKBIA;NLK;CUL9;ACVR1B;FAF1;MAP1LC3C;UBE2A;UBOX5

TCEB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCEB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCEB2.

VHL; TCEB1

Yerlikaya, A; Okur, E; et al. A proteomic analysis of p53-independent induction of apoptosis by bortezomib in 4T1 breast cancer cell line. JOURNAL OF PROTEOMICS 113:315-325(2015).

Chen, J; Ruan, XY; et al. Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor. TUMOR BIOLOGY 35:10993-11003(2014).