Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

TCF12

  • Official Full Name

    transcription factor 12

  • Overview

    The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
  • Synonyms

    TCF12; transcription factor 12; bHLHb20; HEB; helix loop helix transcription factor 4; HsT17266; HTF4; TCF-12; E-box-binding protein; DNA-binding protein HTF4; transcription factor HTF-4; helix-loop-helix transcription factor 4; class B basic helix-loop-h;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TCF12-3157H Recombinant Human TCF12, His-tagged E.coli His 358-706aa
Human TCF12-582H Recombinant Human TCF12 Protein, His-tagged E.coli His
Human TCF12-1183HCL Recombinant Human TCF12 293 Cell Lysate HEK293 N/A
Rat TCF12-5988R Recombinant Rat TCF12 Protein Mammalian Cell His
Rat TCF12-5647R Recombinant Rat TCF12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TCF12-5647R-B Recombinant Rat TCF12 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TCF12-12825Z Recombinant Zebrafish TCF12 Mammalian Cell His
Chicken TCF12-6927C Recombinant Chicken TCF12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TCF12 Related Articles
  • TCF12 Related Research Area

TCF12 involved in several pathways and played different roles in them. We selected most pathways TCF12 participated on our site, such as CDO in myogenesis, Developmental Biology, Id Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
CDO in myogenesisMEF2AA;MEF2B;TCF12;TCF4;CDH4;CDH2;CTNNA2;MYOG;MYOD1
Developmental BiologyDUSP5;NRG3;CARM1;FGF10B;LGI4;CRMP1;FGF20A;JAK3;ACTR2B
Id Signaling PathwayIFI16;ELK3;TCF12;PAX2;TCF3B;MYOD1;MYOG;KDR;MSC
MyogenesisTCF4;TCF12;MYF6;BOC;CDON;MYOD1;MEF2B;MYOG;BNIP2

TCF12 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, SMAD binding, bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF12 itself. We selected most functions TCF12 had, and list some proteins which have the same functions with TCF12. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingTGIF1;ESR1;ARID3B;AEBP2;POU3F2;ETV6;ISL1;SIX1;ZFP639
SMAD bindingEID2;SKOR1;MEF2A;ACVR1B;PRDM16;SKOR1B;SKOR2;BMPR1A;DAB2
bHLH transcription factor bindingTWIST1;MAP3K10;SOX9;ISL1;LMO2;IKZF4;TCF21;USF1;PSMD9
enhancer bindingFOXH1;SOX9;SMAD2;SP1;LEF1;ARNT;ELL3;SMAD3;TIPARP
protein bindingSIAH2;TSPAN6;TMEM171;DDIT3;RASSF4;BAD;ZNF624;CDK9;PIH1D3
protein heterodimerization activityIKBKG;RRAGD;GCLM;HIST2H2AA4;DMRT3;ODZ4;ITGA3;HOMER1;HIST1H2B7
protein homodimerization activityDAXX;DEM1;CHMP3;PRMT8;GSTM7;HPGD;HOGA1;GIPC1;CCBL2
transcription factor activity, sequence-specific DNA bindingHMGA1A;KLF6;PA2G4A;HOXB2;SNAPC5;HOXB6;ZNF92;HIVEP3;KLF5
transcription factor bindingE2F2;KLF5;RORA;WWP2;NLRP3;STAT3;AHR;SOX8;HES4
contributes_to transcription regulatory region DNA bindingHDAC4;NFYC;RXRA;ATF4;HAND1;HDAC5;TCF3;TAF1;NFYB
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingCARF;ONECUTL;BSX;NFIB;POU4F3;HOXC13;HNRNPK;ISL1;TFAP2C

TCF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF12.

HEXIM2; MAPKBP1; CRCP; STK16; PSMA1; SRI; STAT5A

di Rocco, F; Baujat, G; et al. Clinical spectrum and outcomes in families with coronal synostosis and TCF12 mutations. EUROPEAN JOURNAL OF HUMAN GENETICS 22:1413-1416(2014).
Wang, P; Cui, J; et al. Differential expression of microRNAs in 2-cell and 4-cell mouse embryos. ZYGOTE 22:455-461(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All TCF12 Products

Required fields are marked with *

My Review for All TCF12 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends