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TCF7

Official Full Name

transcription factor 7 (T-cell specific, HMG-box)
Overview

The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms

TCF7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7; TCF 1; T-cell-specific transcription factor 1; TCF-1; FLJ36364; MGC47735;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E. coli
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N
C
Myc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TCF7-3159H	Recombinant Human TCF7, His-tagged	E.coli	His	1-384aa	$319 / 25ug
Human	TCF7-1753HCL	Recombinant Human TCF7 cell lysate		N/A		Inquiry
Human	TCF7-119H	Recombinant Human TCF7 Protein, His-tagged	E.coli	His		Inquiry
Human	TCF7-15H	Recombinant Human TCF7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	TCF7-4921H	Recombinant Human TCF7 protein(1-384aa), His&Myc-tagged	E. coli	N-His&C-Myc	1-384aa	Inquiry
Human	TCF7-6778HF	Recombinant Full Length Human TCF7 Protein, GST-tagged	In Vitro Cell Free System	GST	384 amino acids	Inquiry
Mouse	TCF7-16564M	Recombinant Mouse TCF7 Protein	Mammalian Cell	His		Inquiry
Mouse	TCF7-120M	Recombinant Mouse TCF7 Protein, His-tagged	E.coli	His		Inquiry
Mouse	TCF7-9082M	Recombinant Mouse TCF7 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TCF7-9082M-B	Recombinant Mouse TCF7 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TCF7-2043Z	Recombinant Zebrafish TCF7	Mammalian Cell	His		Inquiry
Chicken	TCF7-6116C	Recombinant Chicken TCF7	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TCF7 involved in several pathways and played different roles in them. We selected most pathways TCF7 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Wnt signaling pathway	SERPINF1;WNT6;Fzd4;SFRP1;RHOAB;INVS;NFATC3;RAC1B;TRP53
Hippo signaling pathway	PPP2R2C;CTGF;WNT10B;NF2;MPP5;TGFBR2;TGFB2;ITGB2L;GDF5
Adherens junction	TGFBR1B;PVRL3;WASL;VCLA;ACTN4;ACTG1;CSNK2A1;TCF7;PTPRJ
Melanogenesis	PLCB4;ASIP;MAP2K2B;TYRP1B;WNT5B;WNT7AA;FZD7A;CALM3;CAMK2B
Pathways in cancer	RXRA;PRKCG;TPR;RAC1;EP300;FGF14;MTOR;PTCH1;CTBP2
Colorectal cancer	BAD;MSH6;AKT2;PIK3R2;KRAS;TGFB2;AXIN2;SMAD2;TGFBR1
Endometrial cancer	AKT1;APC2;PDPK1;PIK3CB;CDH1;GRB2;GSK3B;CTNNA2;MAP2K1
Prostate cancer	PDPK1;PIK3CG;HRAS;PDGFB;AKT1;IKBKB;MTOR;SRD5A2;FGFR1
Thyroid cancer	NRAS;TPM3;RXRA;HRAS;CCND1;TCF7;NCOA4;PPARG;RXRG
Basal cell carcinoma	AXIN2;WNT3A;LEF1;FZD9;TCF7;GLI2;FZD1;DVL3;PTCH1
Acute myeloid leukemia	PIK3R1;AKT3;CHUK;IKBKB;MAPK1;CEBPA;RPS6KB1;STAT5B;ZBTB16
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	ITGB7;EMD;ITGA8;ITGAV;ITGA9;TCF7;SGCG;CTNNA1;CACNG6

TCF7 has several biochemical functions, for example, beta-catenin binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TCF7 itself. We selected most functions TCF7 had, and list some proteins which have the same functions with TCF7. You can find most of the proteins on our site.

Function	Related Protein
beta-catenin binding	RORA;CDH2;ASH2L;KLF4;SALL1;C;PTPRU;TCF7L2;PSEN1
chromatin binding	ZNF143;PDX1;GATA1A;JARID2B;RELA;COQ7;ZMYND11;BRD3;FLI1
protein binding	FXYD6;TFPT;PCBP2;H2AFY;LYSMD1;KIAA0319L;CENPL;NMRK1;ATP5G1
sequence-specific DNA binding	FOXS1;NR1D4A;SOX13;TCF7L1A;FOXP2;HOXA11;CUX1;SPIB;LBX1A
transcription factor activity, sequence-specific DNA binding	HIF1A;ZKSCAN6;HIVEP2A;HOXB5A;ZNF182;SIX3;NR1H4;ESRRGA;ALX1
transcription regulatory region DNA binding	NR5A2;RFX3;CTNNB1;ZFHX3;SOX6;WNT1;Ar;TOMM20A;KLF4

TCF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCF7.

CTNNB1; BCR; RUNX3