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TCOF1

Official Full Name

Treacher Collins-Franceschetti syndrome 1
Overview

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

TCOF1; Treacher Collins-Franceschetti syndrome 1; treacle protein; treacle; MFD1; TCOF 1; TCOF_HUMAN; Treacher Collins syndrome protein; OTTHUMP00000160560; OTTHUMP00000224041; OTTHUMP00000224042; OTTHUMP00000224043; OTTHUMP00000224077; OTTHUMP00000227678; OTTHUMP00000231643; nucleolar trafficking phosphoprotein; TCS1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

HEK293
HEK293T
Mamanlian cells
Mammalian Cell
Wheat Germ

Tag

Flag
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TCOF1-32H	Recombinant Human TCOF1 protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	TCOF1-31607TH	Recombinant Human TCOF1	Wheat Germ	N/A	81 amino acids	Inquiry
Human	TCOF1-1170HCL	Recombinant Human TCOF1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TCOF1-3200HFL	Recombinant Full Length Human TCOF1 protein, Flag-tagged	Mamanlian cells	Flag		Inquiry
Mouse	Tcof1-6342M	Recombinant Mouse Tcof1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	TCOF1-4655R	Recombinant Rhesus monkey TCOF1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TCOF1-4471R	Recombinant Rhesus Macaque TCOF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TCOF1-4471R-B	Recombinant Rhesus Macaque TCOF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	TCOF1-2014C	Recombinant Chicken TCOF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TCOF1 involved in several pathways and played different roles in them. We selected most pathways TCOF1 participated on our site, such as Ribosome biogenesis in eukaryotes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TCOF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ribosome biogenesis in eukaryotes	RPP30;NXF3;NOP58;RNASEN;SMFN;NAT10;RCL1;NOL6;CSNK2A2A

TCOF1 has several biochemical functions, for example, poly(A) RNA binding, protein binding, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TCOF1 itself. We selected most functions TCOF1 had, and list some proteins which have the same functions with TCOF1. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	MRPL15;ZCCHC8;HIST1H4N;PHF5A;MTDH;RPL19;WDR3;RBM12B2;EIF3L
protein binding	KIAA0408;NOL6;AVPR2;KLRB1F;HELLS;PKN2;TRIM42;AP5S1;INTS4
transporter activity	SLC25A38B;IGF2R;GOSR2;FABP5;SLCO1A5;RBP2A;RBP2B;SLC4A11;NUP88

TCOF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TCOF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TCOF1.

ARRB2; ARRB1; SRPK2; TTC4; WDR48; USP44; TM9SF1; MED19; RASSF9; ESR1; TOP1; CSNK2A2; CDK2; BECN1