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TERF1

  • Official Full Name

    telomeric repeat binding factor (NIMA-interacting) 1

  • Overview

    This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]
  • Synonyms

    TERF1; telomeric repeat binding factor (NIMA-interacting) 1; TRF; PIN2; TRF1; TRBF1; t-TRF1; hTRF1-AS; telomeric repeat-binding factor 1; NIMA-interacting protein 2; telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • GST|His
  • His
  • His (Fc)
  • Avi
  • GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TERF1-30122TH Recombinant Human TERF1, His-tagged E.coli His 419 amino acids
Human TERF1-5250H Recombinant Human TERF1 Protein, GST/His-tagged E.coli GST/His
Human TERF1-875H Recombinant Human TERF1 protein(Met1-Asp419), His-tagged Insect Cells N-His Met1-Asp419
Human TERF1-1537H Recombinant Human TERF1 protein E.coli N/A
Human TERF1-528HCL Recombinant Human TERF1 cell lysate Insect Cell N/A
Human TERF1-001H Recombinant Human TERF1 Protein, His-GST-tagged E.coli His/GST 1-419
Human TERF1-505H Recombinant Human TERF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TERF1-3059H Recombinant Human TERF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TERF1-002H Recombinant Human TERF1 Protein, His-tagged E.coli His 1-419
Human TERF1-6410H Recombinant Human TERF1 Protein (Ile148-Lys428), N-GST tagged E.coli N-GST Ile148-Lys428
Mouse TERF1-16643M Recombinant Mouse TERF1 Protein Mammalian Cell His
Mouse TERF1-9129M Recombinant Mouse TERF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Terf1-6358M Recombinant Mouse Terf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TERF1-9129M-B Recombinant Mouse TERF1 Protein Pre-coupled Magnetic Beads HEK293
Chicken TERF1-5950C Recombinant Chicken TERF1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TERF1 Related Articles

TERF1 involved in several pathways and played different roles in them. We selected most pathways TERF1 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with TERF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleCDK6;FOXM1;CDC25C;CENPK;RAD21B;HAUS2;CDC20;TEX15;NDE1
Cellular SenescenceCBX4;CDKN2B;RNF2;POT1A;TNIK;CABIN1;PHC3;HIRA;PHC1
Cellular responses to stressHDAC6;RB1CC1;NUP35;GABARAP;EHMT2;HSPA13;HIST1H1B;RNF2;HTATIP
Chromosome MaintenanceCENPA;CENPH;OIP5;CENPK;WRAP53;TINF2;POT1A;MLF1IP;DKC1
DNA Damage/Telomere Stress Induced SenescenceTERF1;HIST1H1E;ASF1A;ACD;HMGA1B;HIRA;RAD50;HIST1H1C;POT1A
MeiosisPOT1;SYNE1;MND1;TERF1;MSH4;TEX12;DMC1;STAG2;SUN1
Meiotic synapsisSYNE2;SYCE1;TERF1;SUN1;SYCE2;POT1;STAG2;TERF2IP;TEX12
Packaging Of Telomere EndsPOT1A;ACD;TERF1;TINF2;POT1;TERF2

TERF1 has several biochemical functions, for example, DNA binding, DNA binding, bending, double-stranded telomeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TERF1 itself. We selected most functions TERF1 had, and list some proteins which have the same functions with TERF1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCCDC71L;ZNF16;AHRRB;CRSP7;NR5A2;TBPL2;LCOR;Ar;SOX6
DNA binding, bendingLEF1;FOXL1;CRIP1;FOXI1;HMGB1;HMGB2;HMGB3;HMGA2;GATA1
double-stranded telomeric DNA bindingPURA;TERFA;TERF1;TERF2
microtubule bindingKIF18B;TERF1;KIF21A;CAMSAP1;KIF3A;KIF3B;SNCA;PPP5C;CHP1
protein bindingSKAP2;PKN1;SIK2;CTC1;BCLAF1;NOV;FAM119A;SUMO1;LAIR2
protein heterodimerization activityFzd4;SYT5;PVRL1;ADIPOR2;BAX;SLC51A;HIST1H3F;SUPT5H;HIST1H2BA
protein homodimerization activityGRPEL1;UGT1A2;DMRTC1B;ANXA6;MCL1A;EFR3A;TENM2;TIMM9;ODZ4
telomeric DNA bindingPOT1A;TERT;TINF2;SMG6;TERF2;TEN1;TERFA;OBFC1;HNRNPD

TERF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TERF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TERF1.

TINF2; PINX1; MAPRE1; TNKS

Gilchrist, GC; Kurjanowicz, P; et al. Telomere Length and Telomerase Activity in Bovine Pre-implantation Embryos In Vitro. REPRODUCTION IN DOMESTIC ANIMALS 50:58-67(2015).
Garrobo, I; Marion, RM; et al. Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats. CELL CYCLE 13:3742-3749(2014).
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