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TFAM

  • Official Full Name

    transcription factor A, mitochondrial

  • Overview

    This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimers and Parkinsons diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
  • Synonyms

    TFAM; transcription factor A, mitochondrial; TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFAM-30255TH Recombinant Human TFAM, His-tagged E.coli His 204 amino acids
Human TFAM-1579H Recombinant Human TFAM protein E.coli N/A
Human TFAM-3416H Recombinant Human TFAM, His-tagged E.coli His
Human TFAM-1765HCL Recombinant Human TFAM cell lysate N/A
Human TFAM-654H Recombinant Human TFAM Protein, His/GST-tagged E.coli His/GST Ser43~Cys246
Human TFAM-6414H Recombinant Human TFAM Protein (Ser43-Cys246), N-GST tagged E.coli N-GST Ser43-Cys246
Human TFAM-301323H Recombinant Human TFAM protein, GST-tagged E.coli GST Pro50-Lys118
Mouse Tfam-27M Recombinant Mouse Tfam protein, His/GST-tagged E.coli His/GST
Mouse TFAM-16675M Recombinant Mouse TFAM Protein Mammalian Cell His
Mouse TFAM-9148M Recombinant Mouse TFAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tfam-655M Recombinant Mouse Tfam Protein, His/GST-tagged E.coli His/GST Ser43-His243
Mouse TFAM-9148M-B Recombinant Mouse TFAM Protein Pre-coupled Magnetic Beads HEK293
Rat TFAM-6024R Recombinant Rat TFAM Protein Mammalian Cell His
Rat TFAM-5683R Recombinant Rat TFAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tfam-656R Recombinant Rat Tfam Protein, His/GST-tagged E.coli His/GST Ser43-Asn244
Rat TFAM-5683R-B Recombinant Rat TFAM Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TFAM-4721Z Recombinant Zebrafish TFAM Mammalian Cell His
Chicken TFAM-5676C Recombinant Chicken TFAM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TFAM Related Articles

TFAM involved in several pathways and played different roles in them. We selected most pathways TFAM participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Huntingtons diseaseATP5J;NDUFV1;TFAM;PLCB4;NDUFS4;POLR2J3;NDUFC2;UQCR11;COX7A1

TFAM has several biochemical functions, for example, DNA binding, bending, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAM itself. We selected most functions TFAM had, and list some proteins which have the same functions with TFAM. You can find most of the proteins on our site.

Function Related Protein
DNA binding, bendingTOP2B;HHEX;GATA1;TERF1;TOP2A;SRY;FOXD4;FOXL1;FOXI1
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNR1D1;ZIC1;IRF1;HAND1;PHOX2B;PLAG1;FOXJ1;MYPOP;KLF17
chromatin bindingNFIA;MORF4L1;YBX1;TRIM37;LEF1;PRMT6;L3MBTL1;CREBBP;ATXN7
heat shock protein bindingNFKBIA;IRAK1;PARK2;APAF1;SSUH2.2;LMAN2;TPR;TOMM34;HSPA8
mitochondrial light strand promoter sense binding
poly(A) RNA bindingADARB2;TXN;BZW1;LSM8;RTCD1;PPP1R10;EXOSC6;EIF3H;ESF1
protein bindingPBXIP1;MOS;BBS1;TEAD3;LILRB4;VSIG4;PBLD;TRAF7;SLC39A7
transcription factor activity, sequence-specific DNA bindingZNF831;NR1H4;HOXD10;ZNF649;ZFP30;FOXH1;MYCS;E4F1;VED
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingSIX1;RELA;PATZ1;NKX2;MYBL1;ETV6;SMAD2;OTX1;ESR1

TFAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAM here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAM.

ARL6IP1; AGTRAP; TFB1M; C1qbp; TFB2M; MCC; IKBKE; TNIK; ssrna_cg

Sotgia, F; Whitaker-Menezes, D; et al. Mitochondria "fuel" breast cancer metabolism Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. CELL CYCLE 11:4390-4401(2012).
Vadrot, N; Ghanem, S; et al. Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3 beta and p53 in Response to Tumor Necrosis Factor alpha. PLOS ONE 7:-(2012).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
07/29/2022

    The protein bands detected were exceptionally distinct, enabling easy interpretation and accurate analysis of protein expression patterns.

    06/22/2021

      To summarize, the TFAM protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.

      12/09/2017

        This level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.

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