TFAM
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Official Full Name
transcription factor A, mitochondrial
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Overview
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimers and Parkinsons diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] -
Synonyms
TFAM; transcription factor A, mitochondrial; TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TFAM Related Articles
TFAM involved in several pathways and played different roles in them. We selected most pathways TFAM participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Huntingtons disease | ATP5J;NDUFV1;TFAM;PLCB4;NDUFS4;POLR2J3;NDUFC2;UQCR11;COX7A1 |
TFAM has several biochemical functions, for example, DNA binding, bending, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAM itself. We selected most functions TFAM had, and list some proteins which have the same functions with TFAM. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding, bending | TOP2B;HHEX;GATA1;TERF1;TOP2A;SRY;FOXD4;FOXL1;FOXI1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | NR1D1;ZIC1;IRF1;HAND1;PHOX2B;PLAG1;FOXJ1;MYPOP;KLF17 |
chromatin binding | NFIA;MORF4L1;YBX1;TRIM37;LEF1;PRMT6;L3MBTL1;CREBBP;ATXN7 |
heat shock protein binding | NFKBIA;IRAK1;PARK2;APAF1;SSUH2.2;LMAN2;TPR;TOMM34;HSPA8 |
mitochondrial light strand promoter sense binding | |
poly(A) RNA binding | ADARB2;TXN;BZW1;LSM8;RTCD1;PPP1R10;EXOSC6;EIF3H;ESF1 |
protein binding | PBXIP1;MOS;BBS1;TEAD3;LILRB4;VSIG4;PBLD;TRAF7;SLC39A7 |
transcription factor activity, sequence-specific DNA binding | ZNF831;NR1H4;HOXD10;ZNF649;ZFP30;FOXH1;MYCS;E4F1;VED |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | SIX1;RELA;PATZ1;NKX2;MYBL1;ETV6;SMAD2;OTX1;ESR1 |
TFAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAM here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAM.
ARL6IP1; AGTRAP; TFB1M; C1qbp; TFB2M; MCC; IKBKE; TNIK; ssrna_cg
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Ask a questionCustomer Reviews (3)
Write a reviewThe protein bands detected were exceptionally distinct, enabling easy interpretation and accurate analysis of protein expression patterns.
To summarize, the TFAM protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.
This level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.
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