TFAP2A
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Official Full Name
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
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Overview
The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer. AP2 alpha is the only AP2 protein required for early morphogenesis of the lens vesicle. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia -
Synonyms
TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); AP2TF, TFAP2, transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha); transcription factor AP-2-alpha; AP 2; AP2-alpha; activator protein 2; AP-;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- His
- His (Fc)
- Avi
- His|Myc
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TFAP2A involved in several pathways and played different roles in them. We selected most pathways TFAP2A participated on our site, such as Caspase cascade in apoptosis, Corticotropin-releasing hormone, Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Caspase cascade in apoptosis | CASP2;CFL2;TFAP2A;DFFA;PARP1;SATB1;NUMA1;CASP4;LMNB1 |
| Corticotropin-releasing hormone | JUND;TRIM28;KRT1;CRHR2;CYP11B1;ADRBK2;CYP11A1;CRHR1;CYP21A2 |
| Neural Crest Differentiation | HOXA1;SOX5;TFAP2A;OLIG3;GBX2;PRTG;MBP;ASCL1;MYB |
| Wnt Signaling Pathway NetPath | NR5A1;PAX2;CRYBB2;MTAP1B;SOX1;BCL9;TCF4;TFAP2A;ANKRD6 |
TFAP2A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2A itself. We selected most functions TFAP2A had, and list some proteins which have the same functions with TFAP2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | CHD7;FOXL2;NKX2-8;ZGPAT;FOSL1;AKNA;NFATC2;KLF13;FOSL2 |
| RNA polymerase II core promoter sequence-specific DNA binding | GATA1;FOS;TCF7L2;ZNF277;ZFPM1;SMAD5;NLRC5;H3F3B;SUZ12 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXE1;ZNF488;ATF4B2;FOXB1;GCM1;MAZ;ETV3;FOXE3;FOXP3A |
| chromatin binding | SMC1AL;NCOA2;ATF5;PKN1;ZNF143;SOX15;MITF;MTA3;MEN1 |
| core promoter proximal region sequence-specific DNA binding | DMRT2A;DMRT2;DMRTA2;KLF4;CREBBP;DMRT3A;SP3;DMRT2B;SMAD3 |
| protein binding | NTHL1;MPZL1;H3F3B;NIPAL3;CDCP1;ITPKB;OTX2;RPLP2;CAMK2G |
| protein dimerization activity | MEF2B;TFAP2C;HER12;HES2.1;MYCB;FERD3L;SOHLH1;HER2;HES7 |
| protein homodimerization activity | HNF1B;ACTN4;STK25;PRDM6;TRIM5;CADM2;GABRR1;IRAK3;TRIM37 |
| sequence-specific DNA binding | NFIL3-6;ISL1L;RARGB;TRP63;RERE;IRF4;EOMES;HOXD3;PPARAB |
| transcription coactivator activity | JUN;CRSP7;LPIN3;MMS19;RARA;HSF2;TAF6L;MED26;RUNX1 |
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | DDN;SNAI3;ARNTL;JDP2;FOSL1A;BATF2;MSX1;FOSL1;SFPI1 |
| transcription factor binding | HDAC11;DNMT1;IFT172;GTF2B;NKX2-5;FIGLA;PURB;TP53;HEYL |
| transcription regulatory region DNA binding | NR1H3;FOXM1;RFX6;CBX4;LEF1;SALL1;ZNF217;REST;RCOR1 |
| transcription regulatory region sequence-specific DNA binding | NFE2L1B;FOXN1;CRY2;SOX12;NR5A5;ZNF658;FOXJ1;ATF3;NFKB1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | KLF5;EBF3A;PITX3;HOXD13;GATA3;ETV1;MYC;TFAP4;ETV4 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ATF3;E2F8;ZGPAT;KLF17;ZFP536;FOXO1;DACH1;PITX2;BTG2 |
TFAP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2A.
UBE2I; NPM1; MKRN3; GSTO2; EP300
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