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TFB1M

  • Official Full Name

    transcription factor B1, mitochondrial

  • Overview

    The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).
  • Synonyms

    TFB1M; transcription factor B1, mitochondrial; dimethyladenosine transferase 1, mitochondrial; CGI 75; dimethyladenosine transferase 1; mitochondrial; mtTFB; hmtTFB; hmtTFB1; hTFB1M; Mitochondrial 12S rRNA dimethylase 1; Mitochondrial transcription factor B1; mtTFB1; h-mtTFB; h-mtTFB1; Mitochondrial dimethyladenosine transferase 1; TFB1M_HUMAN; Transcription factor B1 mitochondrial; homolog of yeast mitochondrial transcription factor B; S-adenosylmethionine-6-N, N-adenosyl(rRNA) dimethyltransferase 1; CGI75; CGI-75;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TFB1M-3194H Recombinant Human TFB1M, GST-tagged E.coli GST 1-346aa
Human TFB1M-3619H Recombinant Human TFB1M, His-tagged E.coli His
Human TFB1M-1785H Recombinant Human Transcription Factor B1, Mitochondrial, His-tagged Human His
Human TFB1M-1136HCL Recombinant Human TFB1M 293 Cell Lysate HEK293 N/A
Mouse TFB1M-16682M Recombinant Mouse TFB1M Protein Mammalian Cell His
Mouse TFB1M-9151M-B Recombinant Mouse TFB1M Protein Pre-coupled Magnetic Beads HEK293
Mouse TFB1M-9151M Recombinant Mouse TFB1M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TFB1M-6025R Recombinant Rat TFB1M Protein Mammalian Cell His
Rat TFB1M-5684R Recombinant Rat TFB1M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TFB1M-5684R-B Recombinant Rat TFB1M Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TFB1M-1016C Recombinant Cynomolgus TFB1M Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey TFB1M-759C-B Recombinant Cynomolgus Monkey TFB1M Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TFB1M-759C Recombinant Cynomolgus Monkey TFB1M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TFB1M-4676R Recombinant Rhesus monkey TFB1M Protein, His-tagged Mammalian Cell His
Rhesus Macaque TFB1M-4492R Recombinant Rhesus Macaque TFB1M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TFB1M-4492R-B Recombinant Rhesus Macaque TFB1M Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TFB1M-4594Z Recombinant Zebrafish TFB1M Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TFB1M Related Articles

TFB1M involved in several pathways and played different roles in them. We selected most pathways TFB1M participated on our site, such as Energy Metabolism, Mitochondrial Gene Expression, Mitochondrial biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFB1M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Energy MetabolismUCP3;ESRRA;MEF2B;MYBBP1A;TFB2M;PPARGC1B;GABPA;TFB1M;UCP2
Mitochondrial Gene ExpressionPOLRMT;MTERFD1;TFB1M;ESRRA;PPARGC1B;TFB2M;PPRC1
Mitochondrial biogenesisESRRA;GABPB1;MTERF;GABPA;POLRMT;C10orf2;TFB1M;TFB2M;PPARGC1B
Organelle biogenesis and maintenanceCC2D2A;C10orf2;DYF-1;MRPS24;EXOC6;MRPL50;NPHP3;TCTEX1D1;MRPL28
Transcriptional activation of mitochondrial biogenesisPPRC1;MTERF;GABPB1;TFB1M;POLG2;POLRMT;C10orf2;GABPA

TFB1M has several biochemical functions, for example, DNA binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFB1M itself. We selected most functions TFB1M had, and list some proteins which have the same functions with TFB1M. You can find most of the proteins on our site.

Function Related Protein
DNA bindingZFP143;RBM5;TRIM27;HLF;PAX7B;ZBTB39;NR6A1;ZNF26;FOXE3
poly(A) RNA bindingDDX39A;MRPS28;CHST13;ZNF622;UBA1;AATF;EIF2S1;RBM26;GAR1
protein bindingAP2S1;PPP1CC;HPX;NPC1;CLUAP1;VCP;TPM1;TLE4;GNPDA2
rRNA (adenine-N6,N6-)-dimethyltransferase activityTRMT10B;NDUFAF5;FBLL1;TRMT10C;METTL23;DIMT1L;PRDM11;PRDM12;METTL21A

TFB1M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFB1M here. Most of them are supplied by our site. Hope this information will be useful for your research of TFB1M.

TFAM; s-adenosyl-l-methionine-1; POLRMT; Srp72; AP4M1; RPL10; YWHAH; ICT1; Rpl35; BAIAP2

Nabokina, SM; Valle, JE; et al. Characterization of the human mitochondrial thiamine pyrophosphate transporter SLC25A19 minimal promoter: A role for NF-Y in regulating, basal transcription. GENE 528:248-255(2013).
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