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TGFBR1

  • Official Full Name

    transforming growth factor, beta receptor 1

  • Overview

    The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Human
  • Mouse
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • C
  • hIgG
  • His
  • Fc
  • Fc Chimera
  • Flag
  • GST
  • hFc
  • Avi
  • mFc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TGFBR1-1495H Active Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST 80 aa-end
Human TGFBR1-695H Active Recombinant Human TGFBR1, Fc-tagged, Biotinylated Human Cell Fc
Human TGFBR1-696H Active Recombinant Human TGFBR1, Fc-tagged Human Cell Fc
Human TGFBR1-242H Active Recombinant Human TGFBR1(T204D)(200-end) Mutation Protein, N-GST-tagged Sf21 GST 200–end
Human TGFBR1-31137TH Recombinant Human TGFBR1 Sf9 Insect Cell N/A 424 amino acids
Human TGFBR1-2346H Active Recombinant Human TGFBR1 protein, His&hFc-tagged HEK293 His&hFc Met1-Glu125
Human TGFBR1-1543H Recombinant Human TGFBR1, Unactive, GST-tagged Sf9 Insect Cell GST 80 aa-end
Human TGFBR1-39H Recombinant Human TGFBR1 (T204D), GST-tagged Sf9 Insect Cell GST
Human TGFBR1-31138TH Recombinant Human TGFBR1 N/A
Human TGFBR1-716H Recombinant Human TGFBR1, GST-His Sf9 Insect Cell GST
Human TGFBR1-83H Recombinant Human TGFBR1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human TGFBR1-5523H Recombinant Human Transforming Growth Factor, Beta Receptor 1 Sf9 Insect Cell N/A
Human TGFBR1-1499H Recombinant Human TGFBR1, GST-tagged Sf9 Insect Cell GST
Human TGFBR1-589H Recombinant Human TGFBR1 Protein, His-tagged E.coli His Glu162~Ala403
Human TGFBR1-8656H Recombinant Human TGFBR1, His-GST tagged Insect Cell His
Human TGFBR1-001HCL Recombinant Human TGFBR1 cell lysate Insect Cell N/A
Human TGFBR1-2482HCL Recombinant Human TGFBR1 cell lysate Human Cell N/A
Human TGFBR1-4379H Recombinant Human TGFBR1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TGFBR1-698H Recombinant Human TGFBR1 Protein, mFc-Avi-tagged HEK293 mFc-Avi Leu34-Glu125
Human TGFBR1-697H Recombinant Human TGFBR1 protein, His-Avi-tagged HEK293 His-Avi Leu34-Glu125
Human TGFBR1-02H Active Recombinant Human TGFBR1 Protein (27-126aa), C-hIgG-His tagged Insect Cell C-hIgG-His 27-126aa
Human TGFBR1-6434H Recombinant Human TGFBR1 Protein (Leu34-Glu125), N-His tagged E.coli N-His Leu34-Glu125
Human TGFBR1-1292H Recombinant Human TGFBR1 Protein (T200-M503), His tagged Insect Cell His T200-M503
Human TGFBR1-143H Active Recombinant Human TGFBR1 protein(Thr200-Met503), His&GST-tagged Insect Cells N-His&GST Thr200-Met503
Human TGFBR1-701H Recombinant Human TGFBR1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TGFBR1-698HB Recombinant Human TGFBR1 protein, mFc-Avi-tagged, Biotinylated HEK293 mFc-Avi Leu34-Glu125
Human TGFBR1-1293H Recombinant Human TGFBR1 Protein (T200-M503), Tag Free Insect Cell No tag T200-M503
Mouse Tgfbr1-439M Active Recombinant Mouse Tgfbr1, Fc Chimera Sf21 Insect Cell Fc Chimera
Mouse Tgfbr1-1777M Active Recombinant Mouse Tgfbr1 Protein, Fc-tagged Insect Cell Fc
Mouse Tgfbr1-6392M Recombinant Mouse Tgfbr1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tgfbr1-175M Recombinant Mouse Tgfbr1(Leu30-Glu125) Protein, C-Fc-tagged HEK293 Fc
Bos taurus (Bovine) RFL6500BF Recombinant Full Length Bovine Tgf-Beta Receptor Type-1(Tgfbr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-499)
Homo sapiens (Human) RFL34739HF Recombinant Full Length Human Tgf-Beta Receptor Type-1(Tgfbr1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (34-503)
Chicken TGFBR1-5819C Recombinant Chicken TGFBR1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TGFBR1 Related Gene Family
  • TGFBR1 Related Research Area
  • TGFBR1 Related Signal Pathway

TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPDGFRB;FGFR4;TNFRSF1A;GRB2;PPP3CCB;CDC25B;FGF21;PRKCBA;TRP53
Cytokine-cytokine receptor interactionCCL3L1;CSF2RB;Ifnlr1;NGFR;TNFRSF6B;CCL7;GHRA;TNFRSF10A;IL3
FoxO signaling pathwayGADD45AB;CCNB3;NLK2;PTENA;GRM1;FOXG1;KLF2B;PDPK1;GABARAPA
EndocytosisARFGAP3;KITA;GRK1A;HSP70L;RABEP1;ARRB2;HLA-E;HGS;SMAD3
TGF-beta signaling pathwayFST;BMP4;ACVR1L;ID3;PPP2R1A;THBS1;BMP8A;TNF;BAMBI
Osteoclast differentiationCYLD;ITGB3;IL1R1;TNFSF11;FOSL2;NFKB2;FOSB;LILRA5;IFNAR1
Hippo signaling pathwayDLG1;AMH;GSK3B;YWHAZ;PPP2R2D;LEF1;PPP2R2A;MPP5;Fzd4
Adherens junctionBAIAP2;ACTN1;PTPRF;ACP1;CTNNA2;WASF3B;ACTN3A;CDC42;CDH1
Chagas disease (American trypanosomiasis)CCL3L3;MAPK8;PPP2R2C;CCL3;CASP8;AKT2;CD3D;IFNGR1;C1QB
Hepatitis BCREB3L2;AKT1;DDX3X;IKBKB;TGFB1;STAT2;CASP9;RELA;TGFB2
HTLV-I infectionMYBL2;MAPK8;IL2RB;POLE4;TGFBR2;PDGFB;PIK3CG;RANBP3;NFKB1
Pathways in cancerLAMB3;LAMA5;DAPK1;Shh;RUNX1;ITGA3;STAT1;GSTP1;HHIP
Colorectal cancerTRP53;SMAD3;AKT2;CCND1;APC;PIK3R3;APPL1;PIK3R2;ARAF
Pancreatic cancerCCND1;TGFBR1;MAPK10;BCL2L1;PIK3R3;MAPK3;RAF1;TGFB3;AKT1
Chronic myeloid leukemiaRB1;ARAF;RELA;MAPK3;TGFB1;SMAD4;SOS1;IKBKG;PIK3CG

TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingEPRS;PRKY;CDC34A;ATP2A1;SLC14A2;KCNJ1;RPS6KA4;TSSK1;HARS2
I-SMAD bindingCTNNB1;AXIN1;TGFB1I1;SMAD7;SMAD1;SMAD2;SMAD6;SMAD4;AXIN2
SMAD bindingTOB1;PURA;MEF2A;USP15;RNF111;SNW1;FOXH1;FLNA;SMAD2
contributes_to growth factor bindingACVR1B;TGFBR1;ERBB2;IL6ST
metal ion bindingSP5;TRIM26;OSGEPL1;ZFP692;OASL2;ABO;TRIM101;ZNF362B;HMOX1
protein bindingMKL1;CDHR1;FAM98A;PLEKHG6;RAB33A;CIB1;IFNA4;EPCAM;DHX36
protein kinase activityNPR1;SCYL1;HIPK3;MAP2K1;ROCK2B;IRAK1;PLK2B;CDK11A;MAPKAPK2B
protein serine/threonine kinase activityPAK2A;ATM;GSK3B;SBK3;PRKD2;MAP3K2;MYLK4;MAPK12B;PRKD1
receptor signaling protein activityNSMAF;DOK2;DCLK1;cgr2b;CD19;ADCYAP1;DOK5;KLK1B3;NGF
receptor signaling protein serine/threonine kinase activityNEK4;PAK2B;TGFBR1B;OXSR1A;ACVRL1;BMPR2A;ACVR2A;SLKA;TGFBR1A
transforming growth factor beta bindingTGFBR3;LTBP1;CD109;ACVR1;VASN;ACVRL1;LTBP4;TGFB3;ITGAV
contributes_to transforming growth factor beta bindingTGFBR1;TGFBR3;TGFBR2;ENG
transforming growth factor beta receptor activity, type IACVR1;TGFBR1;BMPR1B
transforming growth factor beta-activated receptor activityLTBP1;ENG;TGFBR1;BMPR2A;TGFBR2;BMPR2B;ACVRL1;TGFBR3
contributes_to transforming growth factor beta-activated receptor activity
type II transforming growth factor beta receptor bindingTGFB3;TGFBR3;TGFB1A;BAMBI;TGFBR1;ENG;TGFB2;TGFB1

TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.

q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5

TGF
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How can the information of TGFBR1 be used for the development of therapeutic strategies? 04/12/2022

In-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.

Are gene polymorphisms in TGFBR1 associated with disease susceptibility? 09/11/2021

Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.

Is TGFBR1 associated with diseases of the skeletal system? 04/13/2021

Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.

What is the role of the TGFBR1 pathway in liver disease? 12/12/2020

The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.

What are the inhibitors of TGFBR1? 08/01/2020

Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.

What is the relationship between TGFBR1 and kidney disease? 05/29/2020

TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.

Customer Reviews (3)

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Reviews
07/19/2021

    Easy to purify and high purity in production.

    04/22/2021

      The protein has strong reducibility.

      02/17/2021

        He did well in the ELISA test.

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