TGFBR1
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Official Full Name
transforming growth factor, beta receptor 1
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Overview
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta,;transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine;protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple;transcript variants encoding different isoforms have been found for this gene. -
Synonyms
TGFBR1; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II like kinase, 53kD); TGF-beta receptor type-1; activin A receptor type II like kinase; 53kDa; ACVRLK4; ALK 5; tbetaR-I; TGF-beta re;
- Recombinant Proteins
- Cell & Tissue Lysates
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Human
- Mouse
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21
- Sf21 Insect Cell
- Sf9 Insect Cell
- C
- hIgG
- His
- Fc
- Fc Chimera
- Flag
- GST
- hFc
- Avi
- mFc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- TGFBR1 Related Gene Family
- TGFBR1 Related Research Area
- TGFBR1 Related Signal Pathway
TGFBR1 involved in several pathways and played different roles in them. We selected most pathways TGFBR1 participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TGFBR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
MAPK signaling pathway | PDGFRB;FGFR4;TNFRSF1A;GRB2;PPP3CCB;CDC25B;FGF21;PRKCBA;TRP53 |
Cytokine-cytokine receptor interaction | CCL3L1;CSF2RB;Ifnlr1;NGFR;TNFRSF6B;CCL7;GHRA;TNFRSF10A;IL3 |
FoxO signaling pathway | GADD45AB;CCNB3;NLK2;PTENA;GRM1;FOXG1;KLF2B;PDPK1;GABARAPA |
Endocytosis | ARFGAP3;KITA;GRK1A;HSP70L;RABEP1;ARRB2;HLA-E;HGS;SMAD3 |
TGF-beta signaling pathway | FST;BMP4;ACVR1L;ID3;PPP2R1A;THBS1;BMP8A;TNF;BAMBI |
Osteoclast differentiation | CYLD;ITGB3;IL1R1;TNFSF11;FOSL2;NFKB2;FOSB;LILRA5;IFNAR1 |
Hippo signaling pathway | DLG1;AMH;GSK3B;YWHAZ;PPP2R2D;LEF1;PPP2R2A;MPP5;Fzd4 |
Adherens junction | BAIAP2;ACTN1;PTPRF;ACP1;CTNNA2;WASF3B;ACTN3A;CDC42;CDH1 |
Chagas disease (American trypanosomiasis) | CCL3L3;MAPK8;PPP2R2C;CCL3;CASP8;AKT2;CD3D;IFNGR1;C1QB |
Hepatitis B | CREB3L2;AKT1;DDX3X;IKBKB;TGFB1;STAT2;CASP9;RELA;TGFB2 |
HTLV-I infection | MYBL2;MAPK8;IL2RB;POLE4;TGFBR2;PDGFB;PIK3CG;RANBP3;NFKB1 |
Pathways in cancer | LAMB3;LAMA5;DAPK1;Shh;RUNX1;ITGA3;STAT1;GSTP1;HHIP |
Colorectal cancer | TRP53;SMAD3;AKT2;CCND1;APC;PIK3R3;APPL1;PIK3R2;ARAF |
Pancreatic cancer | CCND1;TGFBR1;MAPK10;BCL2L1;PIK3R3;MAPK3;RAF1;TGFB3;AKT1 |
Chronic myeloid leukemia | RB1;ARAF;RELA;MAPK3;TGFB1;SMAD4;SOS1;IKBKG;PIK3CG |
TGFBR1 has several biochemical functions, for example, ATP binding, I-SMAD binding, SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TGFBR1 itself. We selected most functions TGFBR1 had, and list some proteins which have the same functions with TGFBR1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
ATP binding | EPRS;PRKY;CDC34A;ATP2A1;SLC14A2;KCNJ1;RPS6KA4;TSSK1;HARS2 |
I-SMAD binding | CTNNB1;AXIN1;TGFB1I1;SMAD7;SMAD1;SMAD2;SMAD6;SMAD4;AXIN2 |
SMAD binding | TOB1;PURA;MEF2A;USP15;RNF111;SNW1;FOXH1;FLNA;SMAD2 |
contributes_to growth factor binding | ACVR1B;TGFBR1;ERBB2;IL6ST |
metal ion binding | SP5;TRIM26;OSGEPL1;ZFP692;OASL2;ABO;TRIM101;ZNF362B;HMOX1 |
protein binding | MKL1;CDHR1;FAM98A;PLEKHG6;RAB33A;CIB1;IFNA4;EPCAM;DHX36 |
protein kinase activity | NPR1;SCYL1;HIPK3;MAP2K1;ROCK2B;IRAK1;PLK2B;CDK11A;MAPKAPK2B |
protein serine/threonine kinase activity | PAK2A;ATM;GSK3B;SBK3;PRKD2;MAP3K2;MYLK4;MAPK12B;PRKD1 |
receptor signaling protein activity | NSMAF;DOK2;DCLK1;cgr2b;CD19;ADCYAP1;DOK5;KLK1B3;NGF |
receptor signaling protein serine/threonine kinase activity | NEK4;PAK2B;TGFBR1B;OXSR1A;ACVRL1;BMPR2A;ACVR2A;SLKA;TGFBR1A |
transforming growth factor beta binding | TGFBR3;LTBP1;CD109;ACVR1;VASN;ACVRL1;LTBP4;TGFB3;ITGAV |
contributes_to transforming growth factor beta binding | TGFBR1;TGFBR3;TGFBR2;ENG |
transforming growth factor beta receptor activity, type I | ACVR1;TGFBR1;BMPR1B |
transforming growth factor beta-activated receptor activity | LTBP1;ENG;TGFBR1;BMPR2A;TGFBR2;BMPR2B;ACVRL1;TGFBR3 |
contributes_to transforming growth factor beta-activated receptor activity | |
type II transforming growth factor beta receptor binding | TGFB3;TGFBR3;TGFB1A;BAMBI;TGFBR1;ENG;TGFB2;TGFB1 |
TGFBR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TGFBR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TGFBR1.
q99ib8-pro_0000045599; TGFB3; FKBP1A; YWHAZ; TGFB1; Rnf5
- Q&As
- Reviews
Q&As (6)
Ask a questionIn-depth study of the signaling pathways and regulatory mechanisms of TGFBR1 can provide important clues for the development of therapeutic strategies for related diseases.
Gene polymorphisms in TGFBR1 may be associated with susceptibility to some diseases, such as heart disease and diabetes.
Yes, TGFBR1 regulates the proliferation and differentiation of osteocytes in the skeletal system and has been implicated in diseases of the skeletal system.
The TGFBR1 pathway is involved in a variety of pathological processes in liver diseases, such as fibrosis and the occurrence of liver cancer.
Some inhibitors of TGFBR1 have been developed, such as LY2157299 and SD-208.
TGFBR1 may play a role in regulating glomerular injury, fibrosis and renal failure in kidney disease.
Customer Reviews (3)
Write a reviewEasy to purify and high purity in production.
The protein has strong reducibility.
He did well in the ELISA test.
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