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THOC4

Official Full Name

THO complex 4
Overview

The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.
Synonyms

THOC4; THO complex 4; THO complex subunit 4; ALY; ALY/REF; BEF; REF; Ally of AML1 and LEF1; bZIP enhancing factor; THOC 4; THOC-4; Transcriptional coactivator; tho4; OTTHUMP00000218275; ally of AML-1 and LEF-1; bZIP-enhancing factor BEF; transcriptional coactivator Aly/REF;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	THOC4-1093HCL	Recombinant Human THOC4 293 Cell Lysate	HEK293	N/A	Inquiry
Rhesus Macaque	THOC4-4704R	Recombinant Rhesus monkey THOC4 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	THOC4-4518R-B	Recombinant Rhesus Macaque THOC4 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	THOC4-4518R	Recombinant Rhesus Macaque THOC4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein

THOC4 involved in several pathways and played different roles in them. We selected most pathways THOC4 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with THOC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region	LSM11;PAPOLA;CLP1;SLBP;SRSF11;RNPS1;CSTF3;U2AF2;CSTF2
Gene Expression	AIMP2;ARHGEF38;PTBP1A;ZNF785;TRIM33;DNMT3A;TSEN15;PHF19;C14orf166
Herpes simplex infection	PVRL1;CFP;TRAF6;TAF6;NXF1;IKBKB;MCRS1;MAPK8;IFNGR2
Processing of Capped Intron-Containing Pre-mRNA	METTL3;HNRNPR;TXNL4A;CSTF2;NUDT21;DNAJC8;HNRNPA0;RNPC3;PCBP2
RNA Polymerase II Transcription	ZFP473;SRSF11;THOC4;NUDT21;LSM10;U2AF2;CCNT2B;NELFE;GM3258
RNA Polymerase II Transcription Termination	CSTF3;NUDT21;THOC4;CLP1;RNPS1;U2AF2;LSM10;PAPOLA;CSTF1
RNA transport	EIF1AXB;SUMO4;SEH1L;EIF2B2;RPP40;SUMO3B;MAGOHB;KPNB1;EIF4E1B
Spliceosome	HSPA1A;SF3B2;PPIL1;PRPF40A;TXNL4A;SNRPD2;SRSF2;PRPF3;SRSF5B

THOC4 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by THOC4 itself. We selected most functions THOC4 had, and list some proteins which have the same functions with THOC4. You can find most of the proteins on our site.

Function	Related Protein
nucleotide binding	GLULB;HNRNPF;OXSR1A;SART3;RBM12;ACVR2AA;ARL4AB;TRA2A;EWSR1
poly(A) RNA binding	PPIA;CPEB3;SF3B4;DDX54;SART3;EBI3;BICC1;DIEXF;EXOSC10
protein binding	EIF2B4;POC1A;ADIPOQ;SCARA5;GAS1;DLAT;SENP3;CD200R4;NME3

THOC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with THOC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of THOC4.

DDX39B; THOC1; NXF1; THOC5; EIF4A3