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TIMP1

  • Official Full Name

    TIMP metallopeptidase inhibitor 1

  • Overview

    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
  • Synonyms

    TIMP1; TIMP metallopeptidase inhibitor 1; EPA; EPO; HCI; CLGI; TIMP; metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Dog
  • Horse
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Sheep
  • Bovine Plasma
  • CHO
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • Human
  • Human Cell
  • Human Fibroblasts
  • Human Neutrophil
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Rabbit
  • Sf9 Insect Cell
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • SUMO
  • MBP
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TIMP1-002H Active Recombinant Human TIMP1, HIgG1 Fc-tagged CHO Fc
Human TIMP1-30303TH Recombinant Human TIMP1 E.coli N/A
Human TIMP1-287H Recombinant Human metallopeptidase inhibitor 1, His-tagged E.coli His
Human TIMP1-878H Active Recombinant Human TIMP1 protein, His-tagged HEK293 His Met1-Ala207
Human TIMP1-30304TH Recombinant Human TIMP1, His-tagged E.coli His
Human TIMP1-2530H Recombinant Human TIMP Metallopeptidase Inhibitor 1 CHO N/A
Human TIMP1-3194H Active Recombinant Human TIMP1 protein HEK293 N/A Cys24-Ala207
Human TIMP1-5140H Recombinant Human TIMP Metallopeptidase Inhibitor 1 Human N/A
Human TIMP1-4764H Recombinant Human TIMP1 protein, His-tagged HEK293 His 184
Human TIMP1-1688H Recombinant Human TIMP Metallopeptidase Inhibitor 1 Mammalian cells N/A
Human TIMP1-2886H Recombinant Human TIMP Metallopeptidase Inhibitor 1 Sf9 Insect Cell N/A
Human TIMP1-3241H Recombinant Human TIMP1, His-tagged E.coli His 1-169aa
Human TIMP1-77H Recombinant Human TIMP1, His-tagged Insect Cell His
Human TIMP1-30841TH Recombinant Human TIMP1, MBP-tagged E.coli MBP
Human TIMP1-001H Recombinant Human TIMP1 Protein, MBP-tagged E.coli MBP 1-207
Human TIMP1-261H Recombinant Human TIMP1 Protein, Fc-tagged HEK293 Fc
Human TIMP1-601H Recombinant Human TIMP1 Protein, His-tagged HEK293 His
Human TIMP1-2678HCL Recombinant Human TIMP1 cell lysate Human Cell N/A
Human TIMP1-30840TH Native Human TIMP1 Human Fibroblasts N/A
Human TIMP1-92H Native Human TIMP-1 Human Neutrophil N/A
Human TIMP1-132H Recombinant Human TIMP1 Protein, His-tagged Human Cell His
Human CAB11616MH Mouse Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1 Mouse N/A
Human TIMP1-409H Recombinant Human TIMP1 Protein, His-tagged HEK293F N-His Thr25-Ala207
Human CAB11617RH Rabbit Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1 Rabbit N/A
Human TIMP1-4491H-B Recombinant Human TIMP1 Protein Pre-coupled Magnetic Beads HEK293
Human TIMP1-0058H Recombinant Human TIMP1 Protein HEK293 cells
Human TIMP1-4491H Recombinant Human TIMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TIMP1-3036H Recombinant Human TIMP1 protein, His-tagged E.coli His 58-207 aa
Human TIMP1-3188H Recombinant Human TIMP1 Protein (Cys24-Ala207), His tagged E.coli His Cys24-Ala207
Human TIMP1-6456H Recombinant Human TIMP1 Protein (Cys24-Ala207), C-His tagged Mammalian cells C-His Cys24-Ala207
Mouse Timp1-69M Recombinant Mouse Timp1 protein, His-tagged Insect Cell His
Mouse Timp1-3285M Active Recombinant Mouse Timp1 protein HEK293 N/A Met1-Arg205
Mouse Timp1-2788M Recombinant Mouse Timp1 protein, His-tagged E.coli His Ala35~Pro160
Mouse TIMP1-2376MCL Recombinant Mouse TIMP1 cell lysate Human Cell N/A
Mouse Timp1-02M Recombinant Mouse Timp1 Protein, His-tagged Insect Cell His
Mouse TIMP1-1034M Recombinant Mouse TIMP1 Protein, His-tagged HEK293 His
Mouse Timp1-01M Recombinant Mouse Timp1 Protein, His-tagged Insect Cell His
Mouse Timp1-3583M Recombinant Mouse Timp1 protein, His-SUMO-tagged E.coli His-SUMO 25-205aa
Mouse Timp1-6825M Recombinant Mouse Timp1 Protein (Cys25-Arg205) Mammalian cells Tag Free Cys25-Arg205
Mouse Timp1-6436M Active Recombinant Mouse Timp1 Protein, His-tagged HEK293 His Cys27-Arg205
Rat TIMP1-1072R Active Recombinant Rat TIMP1 Protein HEK293 N/A
Rat TIMP1-6076R Recombinant Rat TIMP1 Protein Mammalian Cell His
Rat Timp1-2790R Recombinant Rat Timp1 protein, His-tagged E.coli His Cys24~Ala217 (Accession # P30120)
Rat Timp1-1798R Recombinant Rat TIMP Metallopeptidase Inhibitor 1 Mammalian cells N/A
Rat Timp1-61R Recombinant Rat Timp1 protein, His-tagged Insect Cell His
Rat TIMP1-1490RCL Recombinant Rat TIMP1 cell lysate Human Cell N/A
Rat Timp1-410R Recombinant Rat Timp1 Protein, His-tagged HEK293F N-His Cys24-Ala217
Rat TIMP1-5733R Recombinant Rat TIMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TIMP1-5733R-B Recombinant Rat TIMP1 Protein Pre-coupled Magnetic Beads HEK293
Rabbit TIMP1-2791R Recombinant Rabbit TIMP1 protein, His-tagged E.coli His Cys24~Asp207 (Accession # P20614)
Dog TIMP1-2786D Recombinant Dog TIMP1 protein, His-tagged E.coli His Gln32~Ala207 (Accession # P81546)
Bovine TIMP1-91B Active Native Bovine Thrombin Bovine Plasma N/A
Horse TIMP1-2787H Recombinant Horse TIMP1 protein, His & GST-tagged E.coli His/GST Cys24~Ser178 (Accession # O02722)
Rhesus Macaque TIMP1-4722R Recombinant Rhesus monkey TIMP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TIMP1-4536R Recombinant Rhesus Macaque TIMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TIMP1-4536R-B Recombinant Rhesus Macaque TIMP1 Protein Pre-coupled Magnetic Beads HEK293
Sheep TIMP1-2789S Recombinant Sheep TIMP1 protein, His & T7-tagged E.coli His/T7 Cys24~Cys197 (Accession # P50122)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TIMP1 Related Articles

TIMP1 involved in several pathways and played different roles in them. We selected most pathways TIMP1 participated on our site, such as HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
HIF- signaling pathwayPIK3R2;STAT3;IFNG;CAMK2A;MAPK1;IGF1;EPO;RPS6KB1;PLCG2

TIMP1 has several biochemical functions, for example, cytokine activity, growth factor activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP1 itself. We selected most functions TIMP1 had, and list some proteins which have the same functions with TIMP1. You can find most of the proteins on our site.

Function Related Protein
cytokine activityCCL38A.4;IFNA1;LEFTY2;SCG2;INHBAB;INHBAA;IFNG1-2;IL6;BMP2B
growth factor activityMACC1;FGF6;PROK1;FGF13;CECR1A;INHBC;PSPN;OSM;VEGFC
metal ion bindingZFP27;MBLAC1;PPP1CA;MINA;PDE1C;ZNF193;ACACA;ZBTB1;ZBTB8A
metalloendopeptidase inhibitor activityWFIKKN1;TIMP3;WFIKKN2;FETUB;TIMP2B;BST2;SPOCK3;SPOCK1;NGF
protease bindingTIMP2A;ANXA2;SEMG2;ADRM1;IL1R1;DPP4;TNFAIP3;KIT;ALPI
protein bindingMSMB;TARBP2;CDK13;SND1;CACNB4;CERK;DRAP1;ADRM1;CELF1

TIMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP1.

CD63; MMP9; RECQL5; EEF1B2; SUMO2; ECH1

Shi, M; Movius, J; et al. Cerebrospinal Fluid Peptides as Potential Parkinson Disease Biomarkers: A Staged Pipeline for Discovery and Validation. MOLECULAR & CELLULAR PROTEOMICS 14:544-555(2015).
Krabben, A; Huizinga, TWJ; et al. Biomarkers for Radiographic Progression in Rheumatoid Arthritis. CURRENT PHARMACEUTICAL DESIGN 21:147-169(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the molecular consequences of dysregulated TIMP1 expression in cancer progression? 01/06/2022

Dysregulated TIMP1 expression in cancer can disrupt the balance between MMPs and TIMPs, contributing to excessive extracellular matrix degradation, invasion, and metastasis.

Can you explain the molecular role of TIMP1 in the inhibition of metalloproteinases? 06/30/2020

TIMP1 inhibits metalloproteinases by forming a complex with them, blocking their active sites and preventing the degradation of extracellular matrix components.

How does the nuclear localization of FXN contribute to its role in cellular processes? 03/02/2020

FXN's nuclear localization is associated with its involvement in DNA repair processes, influencing genomic stability and contributing to the overall cellular response to stress.

Can you explain the interplay between TIMP1 and the immune system in inflammatory processes? 07/13/2019

TIMP1 has immunomodulatory effects, influencing inflammation by regulating immune cell migration, cytokine production, and interactions with the extracellular matrix.

What is the significance of TIMP1 in tissue homeostasis and repair? 10/19/2018

TIMP1 plays a crucial role in tissue homeostasis and repair by controlling the activity of MMPs, which are involved in remodeling the extracellular matrix during physiological and pathological processes.

Customer Reviews (3)

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Reviews
04/16/2021

    The efficient delivery of this product ensured that our research timelines were met without any complications.

    08/03/2020

      Impressed by the professionalism of the customer service team—responsive and knowledgeable about the entire product range.

      12/08/2018

        This recombined protein has become a go-to in our lab due to its reliability and the precision it brings to our experiments.

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