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TK2

Official Full Name

thymidine kinase 2, mitochondrial
Overview

This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants.
Synonyms

TK2; thymidine kinase 2, mitochondrial; mt-TK; MTTK; MTDPS2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Cynomolgus Monkey
Human
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TK2-914H	Recombinant Human TK2 Protein, His-tagged	E.coli	His		Inquiry
Human	TK2-1350H	Recombinant Human Thymidine Kinase 2, Mitochondrial, His-tagged	E.coli	His	34-265aa	Inquiry
Human	TK2-3586H	Recombinant Human TK2 protein, His&Myc-tagged	E.coli	His&Myc	34-265aa	Inquiry
Cynomolgus Monkey	TK2-1026C	Recombinant Cynomolgus TK2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	TK2-769C	Recombinant Cynomolgus Monkey TK2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	TK2-769C-B	Recombinant Cynomolgus Monkey TK2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	TK2-839Z	Recombinant Zebrafish TK2	Mammalian Cell	His		Inquiry
Chicken	TK2-3107C	Recombinant Chicken TK2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TK2 Related Articles

TK2 involved in several pathways and played different roles in them. We selected most pathways TK2 participated on our site, such as Pyrimidine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pyrimidine metabolism	NT5C2A;UPRT;POLR2A;POLR2EB;POLR3E;NT5C1B-RDH14;NT5C1A;UCK2;AK9
Drug metabolism - other enzymes	UGT1A1;UGT2A2;UCK2;TK1;UGT5G1;UGT1A9;NAT1;CES1C;UGT1A4
Metabolic pathways	POLR3A;POC1BL;GGT5A;GMPPA;POLR3C;UGT1A1;CPOX;DGKD;AOC1

TK2 has several biochemical functions, for example, ATP binding, deoxycytidine kinase activity, thymidine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TK2 itself. We selected most functions TK2 had, and list some proteins which have the same functions with TK2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	MYH3;PDPK1;GM4922;SPAST;PRKCI;IP6K1;TTLL12;ACSS2;ATP11A
deoxycytidine kinase activity	DCK;TK2
thymidine kinase activity	TK2;TK1

TK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TK2.

Sun, R; Eriksson, S; et al. Oxidative Stress Induced S-glutathionylation and Proteolytic Degradation of Mitochondrial Thymidine Kinase 2. JOURNAL OF BIOLOGICAL CHEMISTRY 287:24304-24312(2012).

Aufderklamm, S; Todenhofer, T; et al. Thymidine kinase and cancer monitoring. CANCER LETTERS 316:6-10(2012).