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TLL1

  • Official Full Name

    tolloid-like 1

  • Overview

    This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TLL1; tolloid-like 1; tolloid-like protein 1; ASD6; TLL; TLL1_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TLL1-3254H Recombinant Human TLL1, His-tagged E.coli His 25-350aa
Human TLL1-1786HCL Recombinant Human TLL1 cell lysate N/A
Human TLL1-419H Recombinant Human TLL1 Protein, His-tagged E.coli N-His Asp730-Ile1003
Human TLL1-2203H Recombinant Human TLL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TLL1-1110H Recombinant Human TLL1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TLL1-2203H-B Recombinant Human TLL1 Protein Pre-coupled Magnetic Beads HEK293
Human TLL1-1333HFL Recombinant Full Length Human TLL1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Tll1-6451M Recombinant Mouse Tll1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TLL1-8641Z Recombinant Zebrafish TLL1 Mammalian Cell His
Chicken TLL1-6268C Recombinant Chicken TLL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TLL1 involved in several pathways and played different roles in them. We selected most pathways TLL1 participated on our site, such as Anchoring fibril formation, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Anchoring fibril formationBMP1B;TLL2;BMP1;TLL1;BMP1A
Assembly of collagen fibrils and other multimeric structuresDST;COL6A2;COL8A1A;PCOLCE;COL4A4;COL10A1;COL4A3;COL10A1A;COL5A2
Collagen biosynthesis and modifying enzymesCOL9A1B;COL13A1;COL28A1D;COL9A1A;COL3A1;CRTAP;COL4A6;COL2A1;COL4A4
Collagen formationCOL10A1A;LOXL1;COL4A5;BMP1B;COL10A1;COL23A1;CTSS;COL5A3A;TLL1
Crosslinking of collagen fibrilsTLL2;ABHD1;BMP1;BMP1A;LOXL2;LOXL3;TLL1;PCOLCE;BMP1B
Degradation of the extracellular matrixKLK7;COL13A1;TIMP2A;ADAMTS1;TPSAB1;CTSLL;ACAN;ADAMTS18;TLL1
Extracellular matrix organizationLTBP3;COL5A2;SPARC;COL4A6;FURINB;CAPNS1;LOC100514666;TPSAB1;LAMB1B

TLL1 has several biochemical functions, for example, calcium ion binding, collagen binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLL1 itself. We selected most functions TLL1 had, and list some proteins which have the same functions with TLL1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingSYTL4;PPP3R2;CANT1B;MAN1B1;CELSR1;SLIT1B;PCDHB13;PCDH2AB9;LTBP4
collagen bindingGP5;ITGA10;RELL2;ADAM9;SERPINH1B;VWF;ITGA9;PODN;FN1
metalloendopeptidase activityNRD1B;ADAMTS16;MMP17;ADAM17A;BMP1;MMP28;IDE;MMP1A;BMP1A
zinc ion bindingMMP7;TRIM38;MEP1A.2;MAN2A2;CHMP1A;RNF141;PHF23A;GFI1AA;TRIM35-1

TLL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLL1.

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