TMEM67
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Official Full Name
transmembrane protein 67
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Overview
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). -
Synonyms
TMEM67; transmembrane protein 67; Meckel syndrome, type 3 , MKS3; Meckelin; JBTS6; MGC26979; NPHP11; meckel syndrome type 3 protein; MKS3; TNEM67;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | TMEM67-3297H | Recombinant Human TMEM67, His-tagged | E.coli | His | 33-354aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- TMEM67 Related Articles
TMEM67 involved in several pathways and played different roles in them. We selected most pathways TMEM67 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMEM67 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | CENPJ;SCLT1;SDCCAG8;B9D1;DYNC1H1;CEP290;CSNK1E;ACTR1A;NEDD1 |
| Assembly of the primary cilium | CEP63;NPHP1;CCDC123;MARK4;EXOC1;AKAP9;TNPO1;UNC119.1;CEP152 |
| Organelle biogenesis and maintenance | UNC119.1;FLR;C10orf2;RAB3IP;MRPL52;ARL3;BBS12;PROL1;C11orf60 |
TMEM67 has several biochemical functions, for example, filamin binding, protein binding, unfolded protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMEM67 itself. We selected most functions TMEM67 had, and list some proteins which have the same functions with TMEM67. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| filamin binding | NEBL;MICALL2;FAM101A;TMEM67;PDLIM2;FAM101B;HSPB7;FBLIM1;ZNF664-FAM101A |
| protein binding | SERINC1;AVPR1A;PARD6B;ARPIN;TMEM19;PKD1;OAZ3;DNAJB4;NEURL1B |
| unfolded protein binding | PFDN2;CLN3;CCT5;CLGN;TTC1;DNAJA3B;SYVN1;DNAJB4;RUVBL2 |
TMEM67 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMEM67 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMEM67.
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