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TMPRSS3

Official Full Name

transmembrane protease, serine 3
Overview

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.
Synonyms

TMPRSS3; transmembrane protease, serine 3; DFNB8, DFNB10; transmembrane protease serine 3; Deafness autosomal recessive 10; DFNB10; DFNB8; ECHOS1; Gene similar to transmembrane serine protease; MGC130589; si:dz69g10.3; TADG12; TMPRSS 3; Tumor associated differentially expressed gene 12 protein; OTTHUMP00000109343; OTTHUMP00000109344; OTTHUMP00000109345; OTTHUMP00000109346; OTTHUMP00000201222; serine protease TADG12; serine protease TADG-12; tumor-associated differentially-expressed gene 12 protein;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TMPRSS3-909HCL	Recombinant Human TMPRSS3 293 Cell Lysate	HEK293	N/A		Inquiry
Homo sapiens (Human)	RFL15557HF	Recombinant Full Length Human Transmembrane Protease Serine 3(Tmprss3) Protein, His-Tagged	E.coli expression system	His	Full Length (1-454)	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TMPRSS3 involved in several pathways and played different roles in them. We selected most pathways TMPRSS3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TMPRSS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TMPRSS3 has several biochemical functions, for example, scavenger receptor activity, serine-type endopeptidase activity, sodium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TMPRSS3 itself. We selected most functions TMPRSS3 had, and list some proteins which have the same functions with TMPRSS3. You can find most of the proteins on our site.

Function	Related Protein
scavenger receptor activity	MARCO;POLR1B;TMPRSS13B;TINAG;CD163;LOXL3B;CCBP2;SCARA5;GM106
serine-type endopeptidase activity	GZMF;KLK9;MCPT8;LONP1;KLK6;F12;HTRA1B;CELA1;LOC780933
sodium channel regulator activity	SCN1BA;PRSS30;FGF12;FXYD4;FXYD1;SGK2B;PTPN3;PKP2;SCN1BB

TMPRSS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMPRSS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TMPRSS3.

RXRA; EEF1A1; TMED7