TNFAIP3
-
Official Full Name
tumor necrosis factor, alpha-induced protein 3
-
Overview
NF-B (nuclear factor B) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The zinc finger protein A20 is a tumor necrosis factor and interleukin 1 (IL-1)-inducible protein that negatively regulates NF-B gene expression by interferring with a novel TNF-induced and RIP-or TRAF2-mediated pathway that is different from the NIK-IB kinase pathway. A20, an 70 kDa protein, is expressed at low levels in most organs, the highest expression levels being in lymphoid tissues. -
Synonyms
TNFAIP3; tumor necrosis factor, alpha-induced protein 3; tumor necrosis factor alpha-induced protein 3; A20; OTUD7C; TNFAIP3 (A20); zinc finger protein A20; TNF alpha-induced protein 3; OTU domain-containing protein 7C; putative DNA-binding protein A20; tumor necrosis factor inducible protein A20; TNFA1P2; MGC104522; MGC138687; MGC138688;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- C
- His
- N
- DDDDK
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- TNFAIP3 Related Research Area
TNFAIP3 involved in several pathways and played different roles in them. We selected most pathways TNFAIP3 participated on our site, such as NF-kappa B signaling pathway, NOD-like receptor signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFAIP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | CCL4L1;TNFAIP3;MAP3K7;PLAU;BCL10;CCL4L2;NFKB2;TRAF3;CCL13 |
| NOD-like receptor signaling pathway | CARD8;CCL2;SUGT1;PSTPIP1A;HSP90AA1.1;MAP3K7;HSP90AB1;IKBKG;CARD18 |
| TNF signaling pathway | RIPK1;MAPK3;FOS;CCL5;SELE;CREB3L3;TRAF3;RPS6KA4;IL18R1 |
| Measles | HSPA1A;TNFSF10;MX1;GSK3B;IFNB1;CD3D;CD28;CLEC4M;PIK3CG |
| Epstein-Barr virus infection | POLR2J2;RBPJL;MAP3K14;HDAC1;MAPK9;PIK3CA;YWHAE;ENTPD1;PSMC3 |
TNFAIP3 has several biochemical functions, for example, DNA binding, K63-linked polyubiquitin binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFAIP3 itself. We selected most functions TNFAIP3 had, and list some proteins which have the same functions with TNFAIP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | FOXF1;ZFP526;HIST1H4E;RUNX2B;HOXC12B;ZBTB48;ENG2B;ZKSCAN14;TGIF2LY |
| K63-linked polyubiquitin binding | TNFAIP3;RNF169;ZRANB1;SQSTM1;PRPF8;ATRIP;SPRTN;ZRANB3;UIMC1 |
| kinase binding | RB1;PARP16;RASGRP3;CEBPB;SNAI1;ATF5;PFKM;RPS3;BARD1 |
| ligase activity | CNOT4;ARIH1;RAG1;UFL1;MKRN2;RTCD1;RNF168;RNF13;BTRC |
| protease binding | STIM1;TIMP2A;SERPINA1E;SERPINB13;Cstb;TIMP4;SEMG2;TRIP4;Casp3 |
| protein binding | KCNRG;BFSP1;IGF2BP1;PTI;PRELID1;SART1;CCND3;RP2;TAC1 |
| protein self-association | PTH1R;CCDC88C;AXIN1;ABCD3;TTN;ADAM8;RYR2;CCL5;VAMP2 |
| ubiquitin binding | USP25;UBR5;USP5;KCNS1;UBE2N;TOP2A;IWS1;FAF1;CXCR4 |
| ubiquitin-protein transferase activity | TRIM24;UHRF1;TRIM36;TRIM37;NLRC4;RNF130;NEDD4L;SMURF1;UBE2C |
| ubiquitin-specific protease activity | VCPIP1;USP3;USP28;USP47;USP14;JOSD2;USP44;OTULIN;OTUB2 |
| zinc ion binding | RABGEF1L;LMX1BB;CA4;CAHZ;BRPF1;ADAM5;NSMCE1;QPCT;PDZRN3 |
TNFAIP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFAIP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFAIP3.
IKBKG; TNIP1; TNIP2; RNF11; TRIM23; TRAF2
- Q&As
- Reviews
Ask a Question for All TNFAIP3 Products
Required fields are marked with *
My Review for All TNFAIP3 Products
Required fields are marked with *
