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Official Full Name
Tnfrsf21 tumor necrosis factor receptor superfamily, member 21
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
TNFRSF21; tumor necrosis factor receptor superfamily, member 21; tumor necrosis factor receptor superfamily member 21; Death receptor 6; TNFR-related death receptor 6; TNFR-related death receptor-6; DR6; TR7; R74815; AA959878