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TNKS

  • Official Full Name

    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

  • Overview

    Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.
  • Synonyms

    TNKS; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; PARP 5a; PARP5A; pART5; TIN1; TINF1; TNKS1; TANK1; TNKS-1; tankyrase I; poly [ADP-ribose] polymerase 5A; TRF1-interacting ankyrin-related ADP-ribose polymerase; PARPL; P;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNKS-3328H Recombinant Human TNKS protein, GST-tagged Wheat Germ GST 1017 a.a. - 1124 a.a.
Human TNKS-3327H Recombinant Human TNKS, GST-tagged E.coli GST 1-329aa
Human TNKS-31498TH Recombinant Human TNKS Wheat Germ N/A 108 amino acids
Human TNKS-0837H Recombinant Human TNKS Protein (Q1091-Q1325), Tag Free E.coli No tag Q1091-Q1325
Human TNKS-459H Recombinant Human TNKS Protein, His-tagged E.coli N-His Gly1105-Thr1327
Human TNKS-0836H Recombinant Human TNKS Protein (Q1091-Q1325), His tagged E.coli His Q1091-Q1325
Mouse TNKS-17187M Recombinant Mouse TNKS Protein Mammalian Cell His
Mouse TNKS-9490M Recombinant Mouse TNKS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNKS-9490M-B Recombinant Mouse TNKS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNKS-4878R Recombinant Rhesus monkey TNKS Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNKS-4692R-B Recombinant Rhesus Macaque TNKS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNKS-4692R Recombinant Rhesus Macaque TNKS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TNKS-5912C Recombinant Chicken TNKS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNKS Related Articles
  • TNKS Related Research Area

TNKS involved in several pathways and played different roles in them. We selected most pathways TNKS participated on our site, such as Degradation of AXIN, Disease, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of AXINTNKS2;TNKS;RNF146
DiseaseELL;PPIA;CPSF4;CHMP4B;DERL2;PRELP;VPS37A;AP1B1;RLBP1
Diseases of signal transductionCPSF6;MYO18A;MIB1;TRAT1;OS9;JAG2;OPN1SW;HEY1;FKBP1A
Regulation of TelomeraseTNKS;MXD1;NR2F2;SP3;DKC1;CMTM2A;PINX1
Signal TransductionRHPN2;RGS4;ARHGAP31;ARHGEF17;RNF146;NPFF;CNGA1;CXCR7B;RYK
Signaling by WNT in cancerKREMEN1;KREMEN2;TNKS2;TNKS;RNF43
Signaling by WntUSP34;RSPO2;FAM123B;RNF43;LEO1;HECW1B;TMED5;KREMEN1;FMNL3
TCF dependent signaling in response to WNTWIF1;PYGO1;USP34;SOX32;C;CCDC88C;TNKS2;RSPO2;SOX9B

TNKS has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS itself. We selected most functions TNKS had, and list some proteins which have the same functions with TNKS. You can find most of the proteins on our site.

Function Related Protein
NAD+ ADP-ribosyltransferase activityART1;GIG2H;PARP14;PARP9;PARP11;TNKS2;ART3;GIG2G;PARP1
protein bindingKIAA1609;FLI1;TBC1D22B;LRPPRC;PAK4;TEX19.1;ZKSCAN3;PIGK;AVPR2
zinc ion bindingMT2A;FTR43;NSMCE1;LMO1;ESR2;ANAPC11;CPSF4;ZCCHC11;ADAM18

TNKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS.

TERF1; FNBP1; Axin1; xav939; CENPJ; nad+

Shebzukhov, YV; Lavrik, IN; et al. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. CANCER IMMUNOLOGY IMMUNOTHERAPY 57:871-881(2008).
Kuimov, AN; Kuprash, DV; et al. Cloning and characterization of TNKL, a member of tankyrase gene family. GENES AND IMMUNITY 2:52-55(2001).
  • Q&As
  • Reviews

Q&As (5)

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What are the potential side effects of targeting TNKS protein in cancer therapy? 08/29/2021

Potential side effects may include gastrointestinal toxicity, hematologic toxicity, and adverse effects on the bone marrow.

How is TNKS protein related to telomere maintenance? 08/21/2021

TNKS protein is involved in the PARP-mediated regulation of telomere length and stability.

How does TNKS protein affect DNA repair mechanisms? 06/29/2021

TNKS protein plays a role in regulating the DNA damage response and repair mechanisms in cells.

Are there any specific inhibitors targeting TNKS protein in clinical use? 01/05/2021

Several inhibitors targeting TNKS protein, such as tankyrase inhibitors, are being evaluated in clinical trials.

Are there any genetic mutations associated with TNKS protein that predispose individuals to certain cancers? 04/19/2017

Mutations in the TNKS gene have been implicated in colorectal cancer and other malignancies.

Customer Reviews (3)

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Reviews
02/13/2023

    One of the key advantages of working with the TNKS protein is the comprehensive support provided by its manufacturer.

    09/20/2021

      This information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.

      12/11/2020

        TNKS is known for its high purity and quality, ensuring accurate and reproducible results.

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