TNKS
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Official Full Name
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
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Overview
Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene. -
Synonyms
TNKS; tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase; tankyrase-1; PARP 5a; PARP5A; pART5; TIN1; TINF1; TNKS1; TANK1; TNKS-1; tankyrase I; poly [ADP-ribose] polymerase 5A; TRF1-interacting ankyrin-related ADP-ribose polymerase; PARPL; P;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | TNKS-3328H | Recombinant Human TNKS protein, GST-tagged | Wheat Germ | GST | 1017 a.a. - 1124 a.a. | |
Human | TNKS-3327H | Recombinant Human TNKS, GST-tagged | E.coli | GST | 1-329aa | |
Human | TNKS-31498TH | Recombinant Human TNKS | Wheat Germ | N/A | 108 amino acids | |
Human | TNKS-0837H | Recombinant Human TNKS Protein (Q1091-Q1325), Tag Free | E.coli | No tag | Q1091-Q1325 | |
Human | TNKS-459H | Recombinant Human TNKS Protein, His-tagged | E.coli | N-His | Gly1105-Thr1327 | |
Human | TNKS-0836H | Recombinant Human TNKS Protein (Q1091-Q1325), His tagged | E.coli | His | Q1091-Q1325 | |
Mouse | TNKS-17187M | Recombinant Mouse TNKS Protein | Mammalian Cell | His | ||
Mouse | TNKS-9490M | Recombinant Mouse TNKS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | TNKS-9490M-B | Recombinant Mouse TNKS Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | TNKS-4878R | Recombinant Rhesus monkey TNKS Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | TNKS-4692R-B | Recombinant Rhesus Macaque TNKS Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | TNKS-4692R | Recombinant Rhesus Macaque TNKS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | TNKS-5912C | Recombinant Chicken TNKS | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- TNKS Related Articles
- TNKS Related Research Area
TNKS involved in several pathways and played different roles in them. We selected most pathways TNKS participated on our site, such as Degradation of AXIN, Disease, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Degradation of AXIN | TNKS2;TNKS;RNF146 |
Disease | ELL;PPIA;CPSF4;CHMP4B;DERL2;PRELP;VPS37A;AP1B1;RLBP1 |
Diseases of signal transduction | CPSF6;MYO18A;MIB1;TRAT1;OS9;JAG2;OPN1SW;HEY1;FKBP1A |
Regulation of Telomerase | TNKS;MXD1;NR2F2;SP3;DKC1;CMTM2A;PINX1 |
Signal Transduction | RHPN2;RGS4;ARHGAP31;ARHGEF17;RNF146;NPFF;CNGA1;CXCR7B;RYK |
Signaling by WNT in cancer | KREMEN1;KREMEN2;TNKS2;TNKS;RNF43 |
Signaling by Wnt | USP34;RSPO2;FAM123B;RNF43;LEO1;HECW1B;TMED5;KREMEN1;FMNL3 |
TCF dependent signaling in response to WNT | WIF1;PYGO1;USP34;SOX32;C;CCDC88C;TNKS2;RSPO2;SOX9B |
TNKS has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNKS itself. We selected most functions TNKS had, and list some proteins which have the same functions with TNKS. You can find most of the proteins on our site.
Function | Related Protein |
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NAD+ ADP-ribosyltransferase activity | ART1;GIG2H;PARP14;PARP9;PARP11;TNKS2;ART3;GIG2G;PARP1 |
protein binding | KIAA1609;FLI1;TBC1D22B;LRPPRC;PAK4;TEX19.1;ZKSCAN3;PIGK;AVPR2 |
zinc ion binding | MT2A;FTR43;NSMCE1;LMO1;ESR2;ANAPC11;CPSF4;ZCCHC11;ADAM18 |
TNKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNKS here. Most of them are supplied by our site. Hope this information will be useful for your research of TNKS.
TERF1; FNBP1; Axin1; xav939; CENPJ; nad+
- Q&As
- Reviews
Q&As (5)
Ask a questionPotential side effects may include gastrointestinal toxicity, hematologic toxicity, and adverse effects on the bone marrow.
TNKS protein is involved in the PARP-mediated regulation of telomere length and stability.
TNKS protein plays a role in regulating the DNA damage response and repair mechanisms in cells.
Several inhibitors targeting TNKS protein, such as tankyrase inhibitors, are being evaluated in clinical trials.
Mutations in the TNKS gene have been implicated in colorectal cancer and other malignancies.
Customer Reviews (3)
Write a reviewOne of the key advantages of working with the TNKS protein is the comprehensive support provided by its manufacturer.
This information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.
TNKS is known for its high purity and quality, ensuring accurate and reproducible results.
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