TNNC1
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Official Full Name
troponin C type 1 (slow)
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Overview
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. -
Synonyms
tnnc1a; Cardiac troponin C; CMH7; cTnI; slow skeletal and cardiac muscles; Slow troponin C1; TN C; TN-C; TNC; TNNC 1; TNNC; TNNC1; TNNC1 protein; TNNC1_HUMAN; TNNI3; Troponin C; Troponin C cardiac; Troponin C slow; Troponin C slow skeletal and cardiac muscles; Troponin C type 1 (slow); Troponin C type 1; Troponin C1 slow; Troponin I type 3 (cardiac);
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- Involved Pathway
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- Interacting Protein
- TNNC1 Related Articles
TNNC1 involved in several pathways and played different roles in them. We selected most pathways TNNC1 participated on our site, such as Calcium signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | RYR2;GRM1;ATP2A1L;CHRM1;CACNA1C;CHRM5;PRKCA;PDE1C;VDAC3 |
| Cardiac muscle contraction | CACNB4;CACNA2D1;COX8A;CACNG8;CACNG7;ATP1A3;FXYD2;CACNB3A;TPM4 |
| Adrenergic signaling in cardiomyocytes | TPM1;AKT3A;TPM2;ADRB2B;PPP2R5D;GNAI3;ATP1A2A;KCNQ1;CAMK2D2 |
| Hypertrophic cardiomyopathy (HCM) | TPM1;PRKAA1;ITGA8;SLC8A1;CACNB3;DMD;PRKAB1;TGFB2;ITGA4 |
| Dilated cardiomyopathy | ITGA5;CACNB4;SGCA;PRKACG;TPM3;TNNC1;ITGB4;LAMA2;CACNA2D4 |
TNNC1 has several biochemical functions, for example, actin filament binding, calcium ion binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNC1 itself. We selected most functions TNNC1 had, and list some proteins which have the same functions with TNNC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin filament binding | VPS16;EZR;ARPC1A;AASS;NEXN;TMOD4;PKNOX2;TRIOBP;CORO1C |
| calcium ion binding | CDH13;ITSN1;SVEP1;TPM4;NID2;CAPRIN1A;BRAF;CDH5;MMP30 |
| calcium-dependent protein binding | NELF;ANXA6;PDCD6;CPNE3;ANXA3;SEC31A;MASP1;A2M;CHP1 |
| metal ion binding | FHL2B;ATP2C2;MARCH9;RORCA;ZNF225;LMX1BB;ACSM1;Scd2;PRKD2 |
| protein homodimerization activity | IRAK2;TRIM5;PAFAH1B2;PYGL;TSC2;DMRTB1;GIPC1;SH3GLB1;S100A16 |
| troponin I binding | TNNC1;TNNI3K;TNNT3;RCAN3 |
| troponin T binding | TNNC1;TNNI2;TNNI3;TNNT1 |
TNNC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNC1.
Ppp1ca; Prkce; Ywhae
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