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TNNI3

  • Official Full Name

    troponin I type 3 (cardiac)

  • Overview

    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
  • Synonyms

    TNNI3; troponin I type 3 (cardiac); CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; troponin I, cardiac muscle; cardiomyopathy, dilated 2A (autosomal recessive);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rat
  • E. coli
  • E.coli
  • Heart
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cardiac
  • Human cardiac tissue
  • Human Heart
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Myc
  • DDK
  • Flag
  • His (Fc)
  • Avi
  • His|SUMO
  • His|T7
  • Myc|DDK
  • N/A
  • N
  • SUMO
  • tag free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNNI3-31690TH Recombinant Human TNNI3 E.coli N/A
Human TNNI3-18H Recombinant Human TNNI3 protein, His-tagged E.coli His
Human TNNI3-27665H Recombinant Human TNNI3, His-tagged E.coli His
Human TNNI3-27226TH Recombinant Human TNNI3 E.coli N/A
Human TNNI3-79H Recombinant Human TNNI3 Insect Cell N/A
Human TNNI3-181H Recombinant Human TNNI3 protein E.coli N/A 210 amino acids
Human TNNI3-220H Recombinant Human Troponin I Type 3 (Cardiac) E.coli N/A
Human TNNI3-164H Recombinant Human TNNI3 Protein, DDK-tagged Insect Cell DDK
Human TNNI3-52H Recombinant Human TNNI3 protein, His-tagged E.coli His
Human TNNI3-1803HCL Recombinant Human TNNI3 cell lysate N/A
Human TNNI3-01H Native Human TNNI3 Protein Human cardiac tissue
Human TNNI3-095H Recombinant Human TNNI3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human Tnni3-1003H Active Recombinant Human cTnI Protein E.coli His
Human TNNI3-2254H Recombinant Human TNNI3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNNI3-872H Recombinant Human TNNI3 Protein, His-tagged E.coli N-His Ala2-Ser210
Human TNNI3-871H Recombinant Human TNNI3 Protein, His-tagged E.coli N-His Met1-Gly203
Human TNNI3-809HFL Recombinant Full Length Human TNNI3 Protein, C-Flag-tagged Mammalian cells Flag
Human TNNI3-873H Recombinant Human TNNI3 Protein, His-tagged HEK293F N-His Ala2-Ser210
Human TNNI3-008H Recombinant Human TNNI3 Protein E.coli 210
Human TNNI3-02H Recombinant Human TNNI3 Protein, His-Tagged E.coli His 260 aa
Human TNNI3-2227H Recombinant Human TNNI3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNNI3-2227H-B Recombinant Human TNNI3 Protein Pre-coupled Magnetic Beads HEK293
Human TNNI3-6483H Recombinant Human TNNI3 Protein (Met1-Gly203), His tagged E.coli His Met1-Gly203
Human TNNI3-0060H Recombinant Human TNNI3 Protein HEK293 cells
Human TNNI3-221H Native Human TNNI3 Human Cardiac N/A
Human TNNI3-6482H Recombinant Human TNNI3 Protein (Met1-Glu161, Thr31-Arg111), C-His tagged E.coli C-His Met1-Glu161, Thr31-Arg111
Human TNNI3-6485H Recombinant Human TNNI3 Protein (Ala28-Glu110), N-His tagged E.coli N-His Ala28-Glu110
Human TNNI3-6484H Recombinant Human TNNI3 Protein (Met1-Ser210), N-His tagged E.coli N-His Met1-Ser210
Human TNNI3-2683H Recombinant Human TNNI3 protein(11-130 aa), N-SUMO & N-His-tagged E. coli N-SUMO & N-His 11-130 aa
Human TNNI3-2682H Recombinant Human TNNI3 protein(61-130 aa), C-His-tagged E. coli C-His 61-130 aa
Human TNNI3-2684H Recombinant Human TNNI3 protein(11-130 aa) E. coli tag free 11-130 aa
Human TNNI3-223H Native Human Troponin I Type 3 (Cardiac) Human Heart N/A
Mouse Tnni3-1388M Recombinant Mouse Tert Protein, His-SUMO-tagged E.coli His/SUMO
Mouse Tnni3-2674M Recombinant Mouse Tnni3 protein, His-tagged E.coli His Met1~Gly211
Mouse Tnni3-17M Recombinant Mouse Tnni3 protein, His-tagged E.coli His
Mouse TNNI3-17196M Recombinant Mouse TNNI3 Protein Mammalian Cell His
Mouse Tnni3-6569M Recombinant Mouse Tnni3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TNNI3-9497M Recombinant Mouse TNNI3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNNI3-9497M-B Recombinant Mouse TNNI3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnni3-7423M Native Mouse Tnni3 Protein Heart
Rat Tnni3-179R Recombinant Rat Tnni3 protein, His-tagged E.coli His
Rat Tnni3-2676R Recombinant Rat Tnni3 protein, His-tagged E.coli His Met1~Gly211 (Accession # P23693)
Rat TNNI3-6209R Recombinant Rat TNNI3 Protein Mammalian Cell His
Rat TNNI3-5866R Recombinant Rat TNNI3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TNNI3-5866R-B Recombinant Rat TNNI3 Protein Pre-coupled Magnetic Beads HEK293
Dog TNNI3-178D Recombinant Dog TNNI3 protein, His/T7-tagged E.coli His/T7
Pig TNNI3-2675P Recombinant Pig TNNI3 protein, His & T7-tagged E.coli His/T7 Ala2~Gly211 (Accession # A5X497)
Chicken TNNI3-7123C Recombinant Chicken TNNI3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNNI3 Related Research Area

TNNI3 involved in several pathways and played different roles in them. We selected most pathways TNNI3 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNI3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayGLP1R;LIPE;VAV2;GIPR;ATP1B4;Adcy4;AKT1;PAK1;ATP1B3
Cardiac muscle contractionCOX6B2;UQCRFS1;CACNA2D1;MYL2;TNNI3;COX5B2;ATP1A2;CACNA1SB;VMHCL
Adrenergic signaling in cardiomyocytesCALML5;PPP2R2D;ADRB2B;PIK3CG;KCNE1;ADCY9;TPM3;RAPGEF4;CREB1A
Hypertrophic cardiomyopathy (HCM)RYR2;ITGB7;SGCA;MYH7;CACNG6;CACNB3;LAMA2;ITGB3;CACNA2D4
Dilated cardiomyopathyITGA4;CACNA2D3;ITGA5;CACNG6;TNNC1;CACNG2;ITGA2B;TNNI3;TPM1

TNNI3 has several biochemical functions, for example, actin binding, calcium channel inhibitor activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNI3 itself. We selected most functions TNNI3 had, and list some proteins which have the same functions with TNNI3. You can find most of the proteins on our site.

Function Related Protein
actin bindingANTXR2A;S100A4;WIPF1A;MYHZ1.1;LCP1;GSN;AKAP5;TPM1;HOOK1
calcium channel inhibitor activityFKBP1B;TNNI3;SLC30A1B;PACSIN3;STX1A;ITPR1;AMBP;SLC30A1;FKBP1AB
calcium-dependent protein bindingKCNIP3;STMN2;S100A1;SEC31A;VPS37C;TSG101;S100P;STX2;S100PBP
metal ion bindingADCY7;ACLY;TIMM10B;PFKMA;ZNF670;KCNIP1B;TDO2;CDKN1A;ZNF549
protein bindingFAM71C;RAB11A;BATF3;CDK9;SENP3;LETM1;GADD45B;MTMR9;KRT5
protein domain specific bindingCASP2;CENPJ;MPP7;YWHAG1;YWHAB;ICA1;RXRA;RARA;CAPG
protein kinase bindingCACNB3;CHEK2;RELA;SPDYB;TPCN2;TRP53;NEK6;PTPN23;RAB11FIP2
troponin C bindingTNNI3;TNNT3
troponin T bindingTNNI2;TNNT1;TNNI3;TNNC1

TNNI3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNI3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNI3.

RCAN3; RCAN3; TNNI3K; PDE4DIP; TNNC1; TNNI3K; TRIM21; TRIM63; SMURF2

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