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TOB1

  • Official Full Name

    transducer of ERBB2, 1

  • Overview

    This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants.
  • Synonyms

    TOB1; transducer of ERBB2, 1; TROB1; protein Tob1; TOB; TROB; transducer of erbB-2 1; proliferation-inducing gene 49; APRO6; PIG49; MGC34446; MGC104792;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TOB1-875HCL Recombinant Human TOB1 293 Cell Lysate HEK293 N/A
Chicken TOB1-1110C Recombinant Chicken TOB1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TOB1 Related Research Area

TOB1 involved in several pathways and played different roles in them. We selected most pathways TOB1 participated on our site, such as BMP signalling and regulation, Diurnally regulated genes with circadian orthologs, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BMP signalling and regulationTOB1;NOG
Diurnally regulated genes with circadian orthologsKLF9;CEBPB;RBPMS;CRY1;QK;DAZAP2;ITM2B;ERC2;UCP3
RNA degradationCNOT3;PFKP;TOB2;ZCCHC7;DDX6;LSM8;EXOSC3;BTG2;PAN2

TOB1 has several biochemical functions, for example, SH3/SH2 adaptor activity, SMAD binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOB1 itself. We selected most functions TOB1 had, and list some proteins which have the same functions with TOB1. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activityGRB14;CRK;SLA2;GRB2;CHN2;CRKL;GRB7;SKAP1;CD28
SMAD bindingAXIN1;SKIA;SKOR2;YY1;TOB1;SKOR1B;CTNNB1;ACVR1B;TGFBRAP1
protein bindingNMB;SDHB;KDM4A;GPATCH8;KIF1B;TAB2;SQSTM1;PKM2;ALKBH3
receptor tyrosine kinase bindingPTPN2;PLCG1;ANGPT2A;NCK1;ANGPT4;DOCK4;ANGPT1;HYAL2;Flt3l
transcription corepressor activityHEYL;SOD3;ZMYND11;RBFOX2;RUNX1T1;CBFA2T3;SMYD1;RYBP;NAB2

TOB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOB1.

CNOT7; CPEB3; CNOT1; PABPC1

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