TOMM22
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Official Full Name
translocase of outer mitochondrial membrane 22 homolog
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Overview
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. -
Synonyms
TOMM22; translocase of outer mitochondrial membrane 22 homolog (yeast); mitochondrial import receptor subunit TOM22 homolog; TOM22; mitochondrial import receptor Tom22; translocase of outer membrane 22 kDa subunit homolog; 1C9-2; MST065; MSTP065;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
TOMM22 involved in several pathways and played different roles in them. We selected most pathways TOMM22 participated on our site, such as Metabolism of proteins, Mitochondrial protein import, Mitophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOMM22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | IGFBP6B;TRAPPC4;GALNTL2;ANKRD28;DPH5;NANP;TIMM9;PFDN2;NAPAA |
| Mitochondrial protein import | COX17;SLC25A12;GFER;TOMM6;LDHD;HSCB;TOMM7;TOMM22;PAM16 |
| Mitophagy | TOMM20;MTERFD1;MFN1;TOMM20B;TOMM7;TOMM70A;TOMM6;LC3;TOMM40 |
| Pink/Parkin Mediated Mitophagy | MTERFD1;LC3;TOMM22;TOMM40;TOMM5;MAP1LC3B;TOMM6;MFN2;MFN1 |
TOMM22 has several biochemical functions, for example, protein binding, contributes_to protein channel activity, protein transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOMM22 itself. We selected most functions TOMM22 had, and list some proteins which have the same functions with TOMM22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MPHOSPH6;XAGE3;SLC30A1;LHX9;C22orf13;SH3GLB2;RFESD;FEM1C;NRIP2 |
| contributes_to protein channel activity | TOMM20L;TOMM20;TOMM7;TOMM20B;TIMM17B;TIMM17A;TOMM22 |
| protein transmembrane transporter activity | AZGP1;TOMM7;TOMM40;TOMM70A;TOMM22;GPIHBP1;BLOC1S3 |
TOMM22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOMM22 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOMM22.
PTP4A3; TOMM40; TOMM7; PHLDA3; PAPD5; XRCC3; ILK; Rmdn3; P; Cdc26; PCDHB15
- Q&As
- Reviews
Q&As (6)
Ask a questionStudies have shown that TOMM22 may be involved in the process of apoptosis. However, its specific mechanism of action and function still need further research.
TOMM22 forms a protein transport channel by interacting with TOMM40 on the inner mitochondrial membrane to transport the proteins required by the mitochondria from the outer mitochondrial membrane to the inner mitochondrial membrane.
The expression level of TOMM22 is regulated by a variety of factors, including transcription factors, epigenetic modifications, and signal transduction pathways. These factors can affect the transcription and translation process of the TOMM22 gene, thereby regulating its expression level in cells.
TOMM22 interacts with other proteins, such as Tom40 on the outer mitochondrial membrane and Tom40 on the inner mitochondrial membrane. These interactions help regulate the function of TOMM22 in cells.
Mutations or aberrant expression of TOMM22 may be associated with a variety of diseases, including neurological diseases, cardiovascular diseases, and cancer. Studies have shown that reduced expression levels or impaired function of TOMM22 may contribute to the occurrence and progression of these diseases.
The activity of TOMM22 can be modulated by different regulatory mechanisms, including phosphorylation and dephosphorylation, interaction with other proteins, and small molecule regulation. These modulating mechanisms can affect the function of TOMM22.
Customer Reviews (3)
Write a reviewThe production process of their recombinant protein is strictly controlled, and the quality of the products is guaranteed.
The high band intensity in Western blot improves the signal-to-noise ratio of the experiment.
It has strong acid and alkali resistance, and is still active under complex conditions.
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