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TONSL

Official Full Name

tonsoku-like, DNA repair protein
Overview

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Synonyms

TONSL; tonsoku-like, DNA repair protein; NFKBIL2, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 2; tonsoku-like protein; IKBR; Inhibitor of kappa B related protein; I kappa B related protein; I-kappa-B-related protein; IkappaBR; Inhibitor of kappa B-related protein; MMS22L-interacting protein; MMS22L-interacting protein, NFBIL2/TONSL; NF kappa B inhibitor like protein 2; NF-kappa-B inhibitor-like protein 2; NFBIL2; NFBIL2/TONSL; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; Protein IkappaBR; TONSL_HUMAN; NFKBIL2;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Rat	TONSL-6222R	Recombinant Rat TONSL Protein	Mammalian Cell	His	Inquiry
Rat	TONSL-5879R	Recombinant Rat TONSL Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	TONSL-5879R-B	Recombinant Rat TONSL Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	TONSL-6222Z	Recombinant Zebrafish TONSL	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
TONSL Related Articles

TONSL involved in several pathways and played different roles in them. We selected most pathways TONSL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TONSL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TONSL has several biochemical functions, for example, histone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TONSL itself. We selected most functions TONSL had, and list some proteins which have the same functions with TONSL. You can find most of the proteins on our site.

Function	Related Protein
histone binding	ZMYND11;NCAPD3;NCAPD2;NPM1;RAG1;SFMBT1;USP3;PKN1;HIST1H3F

TONSL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TONSL here. Most of them are supplied by our site. Hope this information will be useful for your research of TONSL.

Hill, SJ; Rolland, T; et al. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. GENES & DEVELOPMENT 28:1957-1975(2014).

Ohno, Y; Nishimura, T; et al. BRU1 Maintains Configuration of the Euchromatic Subchromosomal Domain in the Nucleus of Arabidopsis. PLANT MOLECULAR BIOLOGY REPORTER 32:19-27(2014).