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TOP1

  • Official Full Name

    topoisomerase (DNA) I

  • Overview

    This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
  • Synonyms

    TOP1; topoisomerase (DNA) I; TOPI; DNA topoisomerase 1; OTTHUMP00000031713; DNA topoisomerase I; type I DNA topoisomerase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Vaccinia virus
  • E.coli
  • HEK293
  • Insect cell
  • Insect Cell
  • Insect Cells
  • Insects cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TOP1-1194H Active Recombinant Human Topoisomerase (DNA) I Sf9 Insect Cell N/A
Human TOP1-3745H Active Recombinant Human TOP1, His-tagged Insect Cell His
Human TOP1-1533H Active Recombinant Human TOP1 Protein Insect cell N/A
Human TOP1-1195H Active Recombinant Human Topoisomerase (DNA) I, Core Domain Sf9 Insect Cell N/A
Human TOP1-1196H Active Recombinant Human Topoisomerase (DNA) I, C-terminal Domain Sf9 Insect Cell N/A
Human TOP1-8479H Active Recombinant Human TOP1, His-tagged Sf21 Insect Cell His
Human TOP1-1197H Active Recombinant Human Topoisomerase (DNA) I, N-terminal Domain Sf9 Insect Cell N/A
Human TOP1-30912TH Recombinant Human TOP1, His-tagged Sf9 Insect Cell His
Human TOP1-31538TH Recombinant Human TOP1 N/A
Human TOP1-31198TH Recombinant Human TOP1, His-tagged His
Human TOP1-30911TH Recombinant Human TOP1, His-tagged His
Human TOP1-351H Recombinant Human TOP1 protein, His-tagged Insect Cell His
Human TOP1-519H Recombinant Human Topoisomerase (DNA) I Insect Cell N/A
Human TOP1-01H Recombinant Human TOP1 Protein, hexa-His-tagged Insects cell His
Human TOP1-867HCL Recombinant Human TOP1 293 Cell Lysate HEK293 N/A
Human TOP1-664H Recombinant Human TOP1 Protein (Met1-Phe765), His-tagged Insect Cell His Met1-Phe765
Human TOP1-1019H Recombinant Human TOP1 Protein (K175-A659), His tagged Insect Cell His K175-A659
Human TOP1-445H Recombinant Human TOP1 Protein, His-tagged E.coli His Met1~Ser250
Human TOP1-1020H Recombinant Human TOP1 Protein (K175-A659), Tag Free Insect Cell No tag K175-A659
Human TOP1-1078H Recombinant Human TOP1 protein(Lys191-Phe765), His-tagged Insect Cells N-His Lys191-Phe765
Mouse TOP1-17228M Recombinant Mouse TOP1 Protein Mammalian Cell His
Mouse TOP1-9517M-B Recombinant Mouse TOP1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Top1-465M Recombinant Mouse Top1 Protein, His-tagged E.coli N-His Met1-Ser252
Mouse TOP1-9517M Recombinant Mouse TOP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TOP1-6223R Recombinant Rat TOP1 Protein Mammalian Cell His
Rat TOP1-5880R-B Recombinant Rat TOP1 Protein Pre-coupled Magnetic Beads HEK293
Rat TOP1-5880R Recombinant Rat TOP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TOP1-4899R Recombinant Rhesus monkey TOP1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TOP1-4713R Recombinant Rhesus Macaque TOP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TOP1-4713R-B Recombinant Rhesus Macaque TOP1 Protein Pre-coupled Magnetic Beads HEK293
Vaccinia virus TOP1-3710V Recombinant Vaccinia virus TOP1 protein, His-tagged E.coli His 1-314aa
Chicken TOP1-6667C Recombinant Chicken TOP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TOP1 Related Articles

TOP1 involved in several pathways and played different roles in them. We selected most pathways TOP1 participated on our site, such as Caspase cascade in apoptosis, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Caspase cascade in apoptosisPARP1;NUMA1;TFAP2A;CASP2;DIABLO;CFL2;GAS2;LMNB1;SATB1
Integrated Pancreatic Cancer PathwayJUND;CASP12;NOXA1;MYT1;TOP2A;FKBP3;BRF1;MST1;GPRC5A

TOP1 has several biochemical functions, for example, DNA binding, DNA topoisomerase type I activity, DNA topoisomerase type II (ATP-hydrolyzing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP1 itself. We selected most functions TOP1 had, and list some proteins which have the same functions with TOP1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPNN;HMGB2B;ZBTB32;ZNF222;POLG;EPAS1;ZNF444;TMPO;HOXA3A
DNA topoisomerase type I activityTOP1L;TOP3B;TOP1MT;CDK5R2;TOP3A;TOP1
DNA topoisomerase type II (ATP-hydrolyzing) activityTOP2A;TOP1MT;TOP2B;TOP1;TOP1L
chromatin bindingTADA2A;WHSC1;BEND6;JDP2;TOP1;PBRM1L;ORC1L;ZGLP1;ENY2
core promoter sequence-specific DNA bindingNR4A3;CHD2;NR1D2;PROX1;ZNF750;ZFP750;NRIP1;PRMT5;CREM
poly(A) RNA bindingZFP36;MRPL44;EXOSC8;U2AF1;HIST1H4A;SNW1;EIF1AX;TRIM25;CCDC9
protein bindingCLK1;ACAD9;RAD51D;SUV39H1;MEGF6;GSG2;EXOSC2;NLRC5;ZNF433

TOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP1.

lt_sv40; NKX3-1; ABL1

Honjo, T; Kobayashi, M; et al. The AID Dilemma: Infection, or Cancer?. ADVANCES IN CANCER RESEARCH, VOL 113 113:1-44(2012).
Nagaoka, H; Tran, TH; et al. Preventing AID, a physiological mutator, from deleterious activation: regulation of the genomic instability that is associated with antibody diversity. INTERNATIONAL IMMUNOLOGY 22:227-235(2010).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the role of TOP1 in the repair of DNA damage caused by environmental factors and chemotherapeutic agents? 12/01/2021

TOP1 repairs DNA damage, maintaining genomic stability under stress.

How do post-translational modifications of TOP1, such as phosphorylation, affect its enzymatic activity and interaction with DNA? 07/17/2021

Post-translational modifications like phosphorylation affect TOP1's activity and DNA interaction.

How do mutations in the TOP1 gene contribute to genomic instability and the development of certain cancers? 02/28/2021

Mutations in TOP1 cause genomic instability, increasing cancer risk.

What are the effects of TOP1 inhibitors on cancer cell proliferation and survival? 12/12/2019

TOP1 inhibitors lead to cancer cell death and inhibit tumor growth by disrupting DNA processes.

How does TOP1 interact with other proteins in the DNA repair and replication machinery? 09/22/2019

TOP1 works with other DNA repair proteins, ensuring accurate DNA synthesis.

How does TOP1 regulate DNA unwinding and re-ligation during transcription and replication? 09/20/2019

TOP1 regulates DNA unwinding by creating transient breaks, aiding transcription and replication.

What are the implications of TOP1 expression levels in predicting the response to chemotherapy in cancer patients? 09/17/2018

TOP1 expression levels predict chemotherapy responses in cancer treatment.

Customer Reviews (3)

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Reviews
10/17/2019

    Accurate protein structural analysis; a key for structural biology.

    10/06/2018

      High-quality protein crystallography; essential for structural biology.

      05/30/2018

        Timely protein characterization; vital for our research projects.

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