TOP1
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Official Full Name
topoisomerase (DNA) I
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Overview
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. -
Synonyms
TOP1; topoisomerase (DNA) I; TOPI; DNA topoisomerase 1; OTTHUMP00000031713; DNA topoisomerase I; type I DNA topoisomerase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Vaccinia virus
- E.coli
- HEK293
- Insect cell
- Insect Cell
- Insect Cells
- Insects cell
- Mammalian Cell
- Sf21 Insect Cell
- Sf9 Insect Cell
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- TOP1 Related Articles
TOP1 involved in several pathways and played different roles in them. We selected most pathways TOP1 participated on our site, such as Caspase cascade in apoptosis, Integrated Pancreatic Cancer Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Caspase cascade in apoptosis | PARP1;NUMA1;TFAP2A;CASP2;DIABLO;CFL2;GAS2;LMNB1;SATB1 |
Integrated Pancreatic Cancer Pathway | JUND;CASP12;NOXA1;MYT1;TOP2A;FKBP3;BRF1;MST1;GPRC5A |
TOP1 has several biochemical functions, for example, DNA binding, DNA topoisomerase type I activity, DNA topoisomerase type II (ATP-hydrolyzing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP1 itself. We selected most functions TOP1 had, and list some proteins which have the same functions with TOP1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | PNN;HMGB2B;ZBTB32;ZNF222;POLG;EPAS1;ZNF444;TMPO;HOXA3A |
DNA topoisomerase type I activity | TOP1L;TOP3B;TOP1MT;CDK5R2;TOP3A;TOP1 |
DNA topoisomerase type II (ATP-hydrolyzing) activity | TOP2A;TOP1MT;TOP2B;TOP1;TOP1L |
chromatin binding | TADA2A;WHSC1;BEND6;JDP2;TOP1;PBRM1L;ORC1L;ZGLP1;ENY2 |
core promoter sequence-specific DNA binding | NR4A3;CHD2;NR1D2;PROX1;ZNF750;ZFP750;NRIP1;PRMT5;CREM |
poly(A) RNA binding | ZFP36;MRPL44;EXOSC8;U2AF1;HIST1H4A;SNW1;EIF1AX;TRIM25;CCDC9 |
protein binding | CLK1;ACAD9;RAD51D;SUV39H1;MEGF6;GSG2;EXOSC2;NLRC5;ZNF433 |
TOP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP1.
lt_sv40; NKX3-1; ABL1
- Q&As
- Reviews
Q&As (7)
Ask a questionTOP1 repairs DNA damage, maintaining genomic stability under stress.
Post-translational modifications like phosphorylation affect TOP1's activity and DNA interaction.
Mutations in TOP1 cause genomic instability, increasing cancer risk.
TOP1 inhibitors lead to cancer cell death and inhibit tumor growth by disrupting DNA processes.
TOP1 works with other DNA repair proteins, ensuring accurate DNA synthesis.
TOP1 regulates DNA unwinding by creating transient breaks, aiding transcription and replication.
TOP1 expression levels predict chemotherapy responses in cancer treatment.
Customer Reviews (3)
Write a reviewAccurate protein structural analysis; a key for structural biology.
High-quality protein crystallography; essential for structural biology.
Timely protein characterization; vital for our research projects.
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