TOP2B
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Official Full Name
topoisomerase (DNA) II beta 180kDa
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Overview
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. -
Synonyms
TOP2B; topoisomerase (DNA) II beta 180kDa; topoisomerase (DNA) II beta (180kD); DNA topoisomerase 2-beta; topo II beta; antigen MLAA-44; topoisomerase IIb; topoisomerase II beta; U937 associated antigen; DNA topoisomerase II beta; DNA topoisomerase II, 18;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
TOP2B involved in several pathways and played different roles in them. We selected most pathways TOP2B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
TOP2B has several biochemical functions, for example, ATP binding, DNA binding, bending, DNA topoisomerase type II (ATP-hydrolyzing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP2B itself. We selected most functions TOP2B had, and list some proteins which have the same functions with TOP2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACTR2A;STK16;INSRB;IRAK3;TNIKA;DGKA;TTL;RUNX2B;PSMC1B |
| DNA binding, bending | FOXC1;FOXL1;HMGA2;TOP2A;FOXD4;CRIP1;GATA1;SRY;FOXD1 |
| DNA topoisomerase type II (ATP-hydrolyzing) activity | TOP1;TOP1MT;TOP2A;TOP1L;TOP2B |
| chromatin binding | KDM8;SETD7;RBMX;TFAP2A;SMAD4;HMGN5;GATA3;PRDM11;GATA2 |
| enzyme binding | PEBP1;CUTA;NOXA1;BTG1;LDB2;AXIN2;CYP2E1;PRKCE;DIS3L |
| histone deacetylase binding | NR2E1;SIRT2;MAGEA2;DDX20;RAD9;HEY2;GMNN;USF1;MAGEA2B |
| metal ion binding | DNAJA3;RPAIN;CDKAL1;PRMT3;ZBTB1;ZFP191;ALKBH4;ESYT1;BNC2 |
| protein C-terminus binding | NCF2;HRAS;KCNJ11;STIP1;MIF4GD;PEX16;CEP135;MYO1C;FBLN1 |
| protein heterodimerization activity | PAFAH1B3;AXL;ADRA2A;HOMER2;MYO5A;KATNB1;ZHX2;PDZD7;ADRB1 |
| protein kinase C binding | HINT1;HDAC5;HDAC7A;HDAC7;AKT2;PARD6A;SDPR;TIRAP;C1QBP |
TOP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP2B.
USF1; ESR1; Top2b; fas_human_gene; PRKCD; UVRAG
- Q&As
- Reviews
Q&As (5)
Ask a questionTOP2B is crucial for chromosome segregation, transcription, and DNA recombination, playing a central role in maintaining genomic stability.
TOP2B helps in remodeling chromatin by resolving supercoils, influencing the accessibility of DNA for various cellular processes.
Increased expression of TOP2B has been associated with resistance to certain chemotherapeutic agents, impacting the efficacy of cancer treatments.
Mutations in TOP2B can lead to impaired DNA repair, genomic instability, and increased susceptibility to various diseases, including certain types of cancer.
Various factors, including cell cycle progression and response to DNA damage, influence the expression of TOP2B to meet the dynamic needs of the cell.
Customer Reviews (3)
Write a reviewThe quality of this product exceeded my expectations, providing precise and reliable results in our experiments.
Rapid delivery! Ordered and received the product within a short timeframe, allowing us to proceed with our experiments without delays.
Exceptional service!
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