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TOP3A

Official Full Name

topoisomerase (DNA) III alpha
Overview

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.
Synonyms

TOP3A; topoisomerase (DNA) III alpha; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase 3 alpha; DNA topoisomerase III alpha; TOP 3; TOP3A_HUMAN; topoisomerase (DNA) III; topoisomerase III alpha; topo III-alpha; OTTHUMP00000065693;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Arabidopsis thaliana (Mouse-ear cress)
Chicken
Human
Mouse

Source

Baculovirus-Insect cells
E. coli
E.coli
HEK293
Mammalian Cell

Tag

C
His
His (Fc)
Avi
His|T7
N
TwinStrep

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TOP3A-3352H	Recombinant Human TOP3A, His-tagged	E.coli	His	652-1001aa	$319 / 25ug
Human	TOP3A-8248H	Recombinant Human TOP3A protein, His & T7-tagged	E.coli	His/T7	Lys35~Ser179 (Accession # Q13472)	Inquiry
Human	TOP3A-6490H	Recombinant Human TOP3A Protein (Lys35-Ser179), N-His tagged	E.coli	N-His	Lys35-Ser179	Inquiry
Human	TOP3A-2853H	Recombinant Human TOP3A protein(911-990 aa), C-His-tagged	E. coli	C-His	911-990 aa	Inquiry
Mouse	TOP3A-17232M	Recombinant Mouse TOP3A Protein	Mammalian Cell	His		Inquiry
Mouse	TOP3A-9521M-B	Recombinant Mouse TOP3A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	TOP3A-9521M	Recombinant Mouse TOP3A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Arabidopsis thaliana (Mouse-ear cress)	TOP3A-1096A	Recombinant Arabidopsis thaliana (Mouse-ear cress) TOP3A Protein (Glu631-Phe926), N-TwinStrep tagged	Baculovirus-Insect cells	N-TwinStrep	Glu631-Phe926	Inquiry
Chicken	TOP3A-4584C	Recombinant Chicken TOP3A	Mammalian Cell	His		Inquiry
Chicken	TOP3A-2343C	Recombinant Chicken TOP3A	Mammalian Cell	His		Inquiry
Chicken	TOP3A-4585C	Recombinant Chicken TOP3A	Mammalian Cell	His		Inquiry
Chicken	TOP3A-4586C	Recombinant Chicken TOP3A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TOP3A Related Articles

TOP3A involved in several pathways and played different roles in them. We selected most pathways TOP3A participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	CDK5R2;RPA2;BRCA2;TOP3B;MUS81;XRCC2;XRCC3;NBN;RAD54B
Fanconi anemia pathway	BRCA1;FANCM;BRIP1;HER6;SLX4;ERCC1;FUZ;SLX1B;FANCA

TOP3A has several biochemical functions, for example, DNA binding, DNA topoisomerase type I activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3A itself. We selected most functions TOP3A had, and list some proteins which have the same functions with TOP3A. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	NR2F6B;STAT3;ZFML;ZNF131;NR6A1A;ZNF512;ZSCAN4C;NR1H3;ZNF776
DNA topoisomerase type I activity	TOP1MT;CDK5R2;TOP3A;TOP1;TOP3B;TOP1L
protein binding	MRM1;RPL11;MUC7;MEA1;SNX7;BAI3;UCHL5;EDF1;MLH3
zinc ion binding	AEBP1;NANOS3;SEC23B;WHSC1;TRPS1;RFPL3;NR2F5;MICALL2;GRIN2B

TOP3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3A here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3A.

BLM; RMI1; TERF2; RIF1; FANCA; ssdna_da; TP53

Kim, HS; Cross, GAM; et al. Identification of Trypanosoma brucei RMI1/BLAP75 Homologue and Its Roles in Antigenic Variation. PLOS ONE 6:-(2011).

Chiappori, AA; Zheng, Z; et al. Features of Potentially Predictive Biomarkers of Chemotherapeutic Efficacy in Small Cell Lung Cancer. JOURNAL OF THORACIC ONCOLOGY 5:484-490(2010).