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TOP3B

Official Full Name

topoisomerase (DNA) III beta
Overview

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.
Synonyms

TOP3B; topoisomerase (DNA) III beta; DNA topoisomerase 3-beta-1; DNA topoisomerase 3 beta 1; DNA topoisomerase III beta 1; FLJ39376; TOP 3B; TOP3B1; Topo III beta; Topoisomerase DNA III beta; Topoisomerase III beta; OTTHUMP00000198579; OTTHUMP00000198581; DNA topoisomerase III beta-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TOP3B-3353H	Recombinant Human TOP3B, GST-tagged	E.coli	GST	510-702aa	$319 / 25ug
Human	TOP3B-8247H	Recombinant Human TOP3B protein, His & T7-tagged	E.coli	His/T7	Met1~Asp250 (Accession # O95985)	Inquiry
Human	TOP3B-1810HCL	Recombinant Human TOP3B cell lysate		N/A		Inquiry
Rhesus Macaque	TOP3B-4901R	Recombinant Rhesus monkey TOP3B Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TOP3B-4715R	Recombinant Rhesus Macaque TOP3B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TOP3B-4715R-B	Recombinant Rhesus Macaque TOP3B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	TOP3B-1330C	Recombinant Chicken TOP3B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TOP3B involved in several pathways and played different roles in them. We selected most pathways TOP3B participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TOP3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	SSBP1;SHFM1;CDK5R2;SYCP3;RPA1;XRCC3;MUS81;POLD4;RAD54B
Fanconi anemia pathway	FANCF;RPA4;HES1;TOP3A;ZBTB32;FANCD2;FANCL;PMS2;USP1

TOP3B has several biochemical functions, for example, DNA binding, DNA topoisomerase activity, DNA topoisomerase type I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOP3B itself. We selected most functions TOP3B had, and list some proteins which have the same functions with TOP3B. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	PBX3B;HIST1H47;ZNF280C;HMG20B;SAFB2;TBX22;HOXA5A;TCF4;IRX3B
DNA topoisomerase activity	TOP3B;CDK5R2
DNA topoisomerase type I activity	TOP3B;TOP1;TOP1L;TOP3A;TOP1MT;CDK5R2
poly(A) RNA binding	HNRNPA1;ZC3H11A;DHX8;TMEM38A;JUN;NLRP11;PNN;RPL19;CCDC9
protein binding	PIN1;PATL1;SH3PXD2A;DUSP12;SCAF8;CYB5R2;MYOCD;CCDC170;CRTC2

TOP3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOP3B here. Most of them are supplied by our site. Hope this information will be useful for your research of TOP3B.

ADAMTSL4; SPRED2; TRIM41; MID2; PNMA2; SSX2IP; AARSD1; KRTAP4-12