CDKN2B
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Official Full Name
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
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Overview
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); P15; MTS2; TP15; CDK4I; INK4B; p15INK4b; cyclin-dependent kinase 4 inhibitor B; MTS-2; p14-INK4b; p14_INK4B; p15-INK4b; p15_INK4B; CDK4B inhibitor; p14_CDK inhibitor; p15 CDK inhibitor; CDK inhibitory protein; multiple tumor suppressor 2; cyclin-dependent kinases 4 and 6 binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- His|T7
- DDK
- N/A
- N
- sumo
- Involved Pathway
- Protein Function
- Interacting Protein
- CDKN2B Related Research Area
CDKN2B involved in several pathways and played different roles in them. We selected most pathways CDKN2B participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle | POT1A;MCM4;CLIP1;GADD45AA;ESPL1;HDAC5;RAD17;CHEK2;GSK3AA |
| Cell Cycle, Mitotic | DCTN1A;CKAP5;CTDNEP1B;ZW10;MAPRE1;GOLGA2;NEDD1;CLIP1;TOP2A |
| Cellular Senescence | PHC1;POT1;TXN;CBX8;TERF1;RBBP4;MAPKAPK2B;MOV10;RING1 |
| Cellular responses to stress | ST13;HSPA13;LC3;CEBPB;CBX6;TERF1;DPF1;HSPH1;ATG9A |
| Cyclin D associated events in G1 | CDKN2C;PIANP;CKS1B;E2F4;CDK7;CDKN2D;CDKN2B |
| FoxO signaling pathway | PRKAA1;BRAF;MAPK9;CDKN1BB;STAT3;AKT1;SGK1;MAPK8A;RAG1 |
| G1 Phase | CKS1B;CDKN2C;E2F4;PIANP;CDKN2B;CDKN2D |
CDKN2B has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2B itself. We selected most functions CDKN2B had, and list some proteins which have the same functions with CDKN2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN1A;CDKN2B;CDKN1B;CDKN1BA;CDKN1BB;HEXIM1;KAT2B;INCA1;Casp3 |
| protein binding | PDGFC;NOMO2;USP54;PAIP1;YARS2;ILVBL;TAF7L;PRDX3;FAM49B |
| protein kinase binding | RELA;FAM83A;HIF1A;AP2A2;NPR1;PTK2;MAP2K3;CCNL1A;TNIP2 |
CDKN2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2B here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2B.
CDK4; CDK6; 80125; TRAF1
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