TPBG
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Official Full Name
trophoblast glycoprotein
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Overview
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. -
Synonyms
5T4; trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1; 5T4AG; TPBG; trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein; 5T4-AG; Naptumomab estafenatox; 676258-98-3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Cynomolgus monkey
- Cynomolgus Monkey
- Cynomolgus/Rhesus macaque
- Human
- Mouse
- Rat
- Rhesus Macaque
- CHO cells
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Mamanlian cells
- Mammalian Cell
- Yeast
- C
- Avi
- 6His
- hFc
- Myc
- DDK
- Fc
- Flag
- His
- His (Fc)
- His\Avi
- His|Myc
- His|SUMO
- mFc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TPBG Related Research Area
TPBG involved in several pathways and played different roles in them. We selected most pathways TPBG participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TPBG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
TPBG has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by TPBG itself. We selected most functions TPBG had, and list some proteins which have the same functions with TPBG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
TPBG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPBG here. Most of them are supplied by our site. Hope this information will be useful for your research of TPBG.
GIPC1; cona_canen
- Q&As
- Reviews
Q&As (7)
Ask a questionElevated TPBG levels can serve as a biomarker and may correlate with poor prognosis in some cancers.
While the post-translational modifications of TPBG are not fully elucidated, they could affect its localization, stability, and interactions with other proteins.
Specific interacting partners of TPBG that significantly influence its function are still under investigation.
TPBG expression is often upregulated in various types of cancer cells.
TPBG might contribute to immune evasion by interacting with immune cells and modulating immune responses.
TPBG plays roles in cell adhesion, migration, and proliferation in normal cells.
Targeting TPBG could provide a therapeutic avenue, particularly in cancers where it is overexpressed, potentially improving immune response and treatment outcomes.
Customer Reviews (3)
Write a reviewReliable and reproducible results.
Worked well for Western blot.
Great for research purposes.
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