TPH1
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Official Full Name
tryptophan hydroxylase 1
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Overview
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009] -
Synonyms
TPH1; tryptophan hydroxylase 1; TPRH; TRPH; tryptophan 5-hydroxylase 1; L-tryptophan hydroxylase; tryptophan 5-monooxygenase 1; indoleacetic acid-5-hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TPH1 Related Articles
- TPH1 Related Research Area
TPH1 involved in several pathways and played different roles in them. We selected most pathways TPH1 participated on our site, such as Tryptophan metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | GCDHA;KYNU;HADH;AOX4;HADHA;INMT;TDO2B;ASMT;ALDH7A1 |
| Metabolic pathways | ASMT;LAP3;POLR2L;SHMT1;ENO2;OGDH;ATP6V1G2;NDUFA4L;POLR1D |
| Serotonergic synapse | ALOX12E;HTR3B;CYP2C54;GNAI1;CYP4X1;GNB4;CYP2C37;TPH2;SLC18A2 |
TPH1 has several biochemical functions, for example, amino acid binding, iron ion binding, tryptophan 5-monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPH1 itself. We selected most functions TPH1 had, and list some proteins which have the same functions with TPH1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| amino acid binding | AARS2;DDAH2;AGXT;TPH1B;TAT;DDAH1;TPH2;OTC;DPYS |
| iron ion binding | NOS3;CYP2K6;CYP2AD6;PPEF1;HBB-B2;CYP2J5;CYP2H1;NOS1;CYGB |
| tryptophan 5-monooxygenase activity | TH2;TPH1;TPH1A;TPH2;TPH1B |
TPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPH1.
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- Q&As
- Reviews
Q&As (5)
Ask a questionTPH1 protein can be measured in clinical practice using techniques such as enzyme-linked immunosorbent assay (ELISA) or immunohistochemistry.
TPH1 protein contributes to the regulation of circadian rhythm by influencing the synthesis of serotonin, which in turn affects mood, sleep, and behavior.
TPH1 protein is involved in the gut-brain axis by influencing serotonin production in the gastrointestinal tract, which in turn can affect mood and behavior.
TPH1 polymorphisms have implications in clinical settings as they are associated with variations in serotonin levels and susceptibility to psychiatric disorders.
TPH1 inhibitors have potential clinical applications in the treatment of psychiatric disorders, gastrointestinal disorders, and migraine.
Customer Reviews (3)
Write a reviewthe TPH1 protein stands out for its exceptional quality and its ability to fulfill my experimental requirements.
Its compatibility with various methodologies further enhances its value as a research tool, making it a go-to choice for investigating TPH1 protein function and molecular interactions.
The versatility of the TPH1 protein extends beyond these applications, enabling its use in a wide range of experimental techniques.
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