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TPM3

  • Official Full Name

    tropomyosin 3

  • Overview

    This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    TPM3; tropomyosin 3; NEM1; tropomyosin alpha-3 chain; TRK; tropomyosin-3; tropomyosin-5; gamma-tropomyosin; tropomyosin gamma; cytoskeletal tropomyosin TM30; heat-stable cytoskeletal protein 30 kDa; TM3; TM5; CFTD; TM-5; TM30; hTM5; TM30nm; TPMsk3; hscp30;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPM3-93H Active Recombinant Human TPM3, GST-tagged Sf9 Insect Cell GST
Human TPM3-94H Active Recombinant Human TPM3, GST-tagged Sf9 Insect Cell GST
Human TPM3-30684TH Recombinant Human TPM3 E.coli N/A
Human TPM3-28H Recombinant Human TPM3 E.coli N/A
Human TPM3-55H Recombinant Human TPM3, His-tagged E.coli His
Human TPM3-30392TH Recombinant Human TPM3, His-tagged E.coli His 248 amino acids
Human TPM3-29H Recombinant Human TPM3, MYC/DDK-tagged HEK293 Myc/DDK
Human TPM3-3370H Recombinant Human TPM3, GST-tagged E.coli GST 1-285aa
Human TPM3-4853H Recombinant Human Tropomyosin 3, His-tagged E.coli His
Human TPM3-842HCL Recombinant Human TPM3 293 Cell Lysate HEK293 N/A
Human TPM3-1953H Recombinant Human TPM3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM3-1380H Recombinant Human TPM3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM3-8979HFL Recombinant Full Length Human TPM3, Flag-tagged Mamanlian cells Flag
Human TPM3-6661H Recombinant Human TPM3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM3-3040H Recombinant Human TPM3 protein, His-tagged E.coli His 1-285 aa
Human TPM3-4621H Recombinant Human TPM3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPM3-0146H Recombinant Human TPM3 Protein (M2-I285), Tag Free Insect Cell No tag M2-I285
Human TPM3-0145H Recombinant Human TPM3 Protein (M2-I285), His/GST tagged Insect Cell His/GST M2-I285
Human TPM3-6502H Recombinant Human TPM3 Protein (Met1-Ile285), N-His tagged E.coli N-His Met1-Ile285
Mouse Tpm3-8048M Recombinant Mouse Tpm3 protein, His & T7-tagged E.coli His/T7 Thr6~Met248 (Accession # P21107)
Mouse TPM3-17258M Recombinant Mouse TPM3 Protein Mammalian Cell His
Mouse Tpm3-6600M Recombinant Mouse Tpm3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TPM3-9538M Recombinant Mouse TPM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TPM3-9538M-B Recombinant Mouse TPM3 Protein Pre-coupled Magnetic Beads HEK293
Rat TPM3-6243R Recombinant Rat TPM3 Protein Mammalian Cell His
Rat TPM3-5900R-B Recombinant Rat TPM3 Protein Pre-coupled Magnetic Beads HEK293
Rat Tpm3-471R Recombinant Rat Tpm3 Protein, His-tagged E.coli N-His Ala2-Met248
Rat TPM3-5900R Recombinant Rat TPM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TPM3-4919R Recombinant Rhesus monkey TPM3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TPM3-4733R-B Recombinant Rhesus Macaque TPM3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TPM3-4733R Recombinant Rhesus Macaque TPM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish TPM3-11537Z Recombinant Zebrafish TPM3 Mammalian Cell His
Chicken TPM3-4525C Recombinant Chicken TPM3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TPM3 involved in several pathways and played different roles in them. We selected most pathways TPM3 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cardiac muscle contractionUQCRB;MYL4;UQCRFS1;UQCRC2;ACTC1A;COX7A2A;COX6B2;TNNC1B;SLC9A1
Adrenergic signaling in cardiomyocytesVMHC;CREB1A;TPM4;GNAS;ATP2B4;MYH15;TNNC1B;CACNB1;ATP1A3B
Pathways in cancerBAX;BIRC5;BRCA2;GNA11;MAPK3;MMP1;FGF6;MITF;FGF18
Thyroid cancerTRP53;RXRA;CDH1;MAPK3;RXRG;PPARG;TFG;TCF7L2;CCND1
Hypertrophic cardiomyopathy (HCM)PRKAB2;LMNA;SGCG;TNNC1;ITGB4;PRKAB1;ITGB5;TPM3;IL6
Dilated cardiomyopathyCACNA2D4;CACNB1;ATP2A2;CACNA2D2;ACTG1;ITGA2B;ITGB8;ITGB7;TTN

TPM3 has several biochemical functions, for example, actin binding, molecular_function, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPM3 itself. We selected most functions TPM3 had, and list some proteins which have the same functions with TPM3. You can find most of the proteins on our site.

Function Related Protein
actin bindingMYH9;INPPL1A;PARK2;STK38L;MYO10;MYH15;TAGLN;SHROOM2;CLMN
molecular_functionPRNPB;PLA2G12B;NLRP4E;FLOT2B;TUSC2B;CPNE2;ZNF614;GM606;SETD5
protein bindingGPSM2;PLSCR1;ABCG1;UCN;VPS53;ESYT2;CXXC5;RGP1;DUSP9

TPM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPM3.

KXD1; MAD1L1; IKBKE; 374666; TFPT; OIP5; LCA5L

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