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TPP2

  • Official Full Name

    tripeptidyl peptidase II

  • Overview

    This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class.
  • Synonyms

    TPP2; tripeptidyl peptidase II; tripeptidyl-peptidase 2; TPP-II; tripeptidyl-peptidase II; tripeptidyl aminopeptidase; TPP-2; FLJ40359;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPP2-840HCL Recombinant Human TPP2 293 Cell Lysate HEK293 N/A
Human TPP2-6449H Recombinant Human TPP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPP2-4609H Recombinant Human TPP2 protein, His&Myc-tagged Insect Cell His&Myc 44-264aa
Human TPP2-4606H Recombinant Human TPP2 protein, His&Myc-tagged E.coli His&Myc 44-264aa
Human TPP2-1098HFL Recombinant Full Length Human TPP2 Protein, C-Flag-tagged Mammalian cells Flag
Human TPP2-3438H Recombinant Human TPP2 protein, His-tagged E.coli His 900-1249 aa
Human TPP2-476H Recombinant Human TPP2 Protein, His-tagged E.coli N-His Ile40-Asp509
Human TPP2-2242H Recombinant Human TPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TPP2-2242H-B Recombinant Human TPP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TPP2-17263M Recombinant Mouse TPP2 Protein Mammalian Cell His
Mouse Tpp2-6604M Recombinant Mouse Tpp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TPP2-9543M-B Recombinant Mouse TPP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TPP2-9543M Recombinant Mouse TPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tpp2-1308M Recombinant Mouse Tpp2 protein, His&Myc-tagged HEK293 His&Myc 44-264aa
Mouse Tpp2-4607M Recombinant Mouse Tpp2 protein, His&Myc-tagged E.coli His&Myc 44-264aa
Mouse Tpp2-4608M Recombinant Mouse Tpp2 protein, His&Myc-tagged Insect Cell His&Myc 44-264aa
Rat TPP2-6246R Recombinant Rat TPP2 Protein Mammalian Cell His
Rat TPP2-5903R Recombinant Rat TPP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TPP2-5903R-B Recombinant Rat TPP2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

TPP2 involved in several pathways and played different roles in them. We selected most pathways TPP2 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemKIF3A;CD207;TRAF7;KLRB1B;CD300C;AHCYL1;MKRN1;STIM1B;CLEC2D
Antigen processing: Ubiquitination &ampRNF111;ARIH2;ASB8;WSB1;UBE2F;PJA2;RNF19B;CMTM2A;UFL1
Proteasome degradationCMTM2A;TRIM39;LRR1;RBCK1;RNF111;STUB1;IWS1;TRIM11;LRSAM1
Class I MHC mediated antigen processing &ampWWP1;ATG7;ASB8;GAN;UFL1;UBE2V2;CTSL2;LRRC41;UBE2U
presentationTRIM11;SEC24A;KLHL20;TRAF7;UBR2;TRIM63;ASB4;RNF4;NPEPPS
Immune SystemCD300LG;S100A12;RNF220;ASB14;PRLRB;TRIM48;KIF5A;LTF;ACTR1B

TPP2 has several biochemical functions, for example, aminopeptidase activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPP2 itself. We selected most functions TPP2 had, and list some proteins which have the same functions with TPP2. You can find most of the proteins on our site.

Function Related Protein
aminopeptidase activityPHEX;Npepo;ERAP1;ENPEP;XPNPEP2;ANPEP;DPP9;Ctsl;NPEPL1
endopeptidase activityCASP1;PSMB11;PSMB6;SENP3;CD46;RHBDD1;REN2;SENP3A;PSMB8F
protein bindingPLXDC1;FBXO27;WDR48;VENTX;RRP8;FAT4;EIF2AK3;TTC32;NAMPT
serine-type endopeptidase activityF10;HABP2;PCSK5B;IMMP1L;PROZ;PRTN3;RHBDD2;HTRA3;C1S
tripeptidyl-peptidase activityTPP1;TPP2;ACE

TPP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPP2.

POLB; EHHADH; PPP1R16A; MCC; HLA-B; GAMMAHV.ORF68

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