TPR
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Official Full Name
translocated promoter region, nuclear basket protein
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Overview
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5 end of this gene with several different kinase genes occur in some neoplasias. -
Synonyms
TPR; translocated promoter region, nuclear basket protein; translocated promoter region (to activated MET oncogene); nucleoprotein TPR; tumor potentiating region; nuclear pore complex-associated protein TPR;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Trypanosoma Cruzi
- E.coli
- HEK293
- Mammalian Cell
- Sf9 Insect Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | TPR-95H | Active Recombinant Human TPR, GST-tagged | Sf9 Insect Cell | GST | ||
Human | TPR-30424TH | Recombinant Human TPR, His-tagged | E.coli | His | ||
Rat | TPR-6248R | Recombinant Rat TPR Protein | Mammalian Cell | His | ||
Rat | TPR-5905R | Recombinant Rat TPR Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | TPR-5905R-B | Recombinant Rat TPR Protein Pre-coupled Magnetic Beads | HEK293 | |||
Trypanosoma Cruzi | TPR-1748T | Recombinant Trypanosoma Cruzi TPR Protein (1-492 aa), His-tagged | Yeast | His | 1-492 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- TPR Related Articles
TPR involved in several pathways and played different roles in them. We selected most pathways TPR participated on our site, such as RNA transport, Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
RNA transport | POM121L2;NCBP1;POP4;EEF1A1L2;POP7;EIF2B5;THOC5;EIF4G2;UPF3B |
Pathways in cancer | AKT1;RAC1;MAPK8;PTK2;PRKCA;PLCB2;HIF1A;MMP1;HDAC2 |
Thyroid cancer | MAPK1;TFG;RET;LEF1;TP53;NTRK1;TPR;RXRG;BRAF |
TPR has several biochemical functions, for example, chromatin binding, dynein complex binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPR itself. We selected most functions TPR had, and list some proteins which have the same functions with TPR. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
chromatin binding | CUX1;COQ7;MSH6;APBB1;HDAC7;TP53;ACTL6A;MLL1;ORC1L |
dynein complex binding | TPR;HDAC6;CCDC155 |
heat shock protein binding | DNAJA2;DNAJA2L;APAF1;BAX;IRAK1;DNAJA3A;CDC37L1;DNAJA3;HSPA8 |
mRNA binding | LIN28A;HNRPLL;SRRM4;AGO2;RPS2;QK;PAIP2;CPSF6;DCP1B |
mitogen-activated protein kinase binding | ACE;MAPKAPK2;DUSP2;ATF7;PTPRJ;TPR;NBR1;ARRB2;MAPKAPK2B |
molecular_function | BHLHA9;DNALC1;GNB1L;XKR9;CBLN8;LSM12B;GOLIM4;PPFIBP2;ZSWIM4 |
nucleocytoplasmic transporter activity | NUPL1;NUP133;UPF3A;NUP35;TPRB;NUP214;XPO1;NUP54;NUP160 |
poly(A) RNA binding | SRP54;RTN4;ARF1;SNRPA;RBMX;SUB1;RARS2;HNRNPDL;ADARB1 |
NOT protein anchor | |
protein binding | IKZF2;ARMC8;NUDCD2;KIAA1967;PYGM;FEM1B;AHNAK2;MED31;OLFM4 |
protein homodimerization activity | MLL1;NPPC;USF2;CEP57;SP100;NBL1;DMBX1;ADRA2C;NPM1 |
NOT transporter activity | |
tubulin binding | STMN1B;EML2;CLIP1;PARK2;STMN4;RITA1;TPPP;STMN4L;STMN2 |
TPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPR here. Most of them are supplied by our site. Hope this information will be useful for your research of TPR.
Mad2l1; MAD1L1; FOS; SMAD2; Tpr; Kifc1; TRAF6; APC; SF1; MAP3K4; midostaurin; Katna1; CBX7; FN1; VCAM1
- Q&As
- Reviews
Q&As (5)
Ask a questionPotentially, as TPR proteins play diverse roles in cellular processes, targeting them could lead to personalized therapeutic approaches for various diseases.
Some TPR proteins are involved in regulating cellular signaling pathways, influencing processes such as cell growth, differentiation, and apoptosis.
Some TPR proteins are involved in regulating mitochondrial function, which could have implications for diseases related to mitochondrial dysfunction.
TPR proteins are involved in the transport of proteins and other molecules within the cell, regulating the movement of cargo between different cellular compartments.
Research suggests that targeting TPR proteins involved in protein folding and transport could be a potential therapeutic approach for neurodegenerative diseases.
Customer Reviews (3)
Write a reviewIts consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.
The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.
The TPR protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.
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