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TPR

  • Official Full Name

    translocated promoter region, nuclear basket protein

  • Overview

    This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5 end of this gene with several different kinase genes occur in some neoplasias.
  • Synonyms

    TPR; translocated promoter region, nuclear basket protein; translocated promoter region (to activated MET oncogene); nucleoprotein TPR; tumor potentiating region; nuclear pore complex-associated protein TPR;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Trypanosoma Cruzi
  • E.coli
  • HEK293
  • Mammalian Cell
  • Sf9 Insect Cell
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPR-95H Active Recombinant Human TPR, GST-tagged Sf9 Insect Cell GST
Human TPR-30424TH Recombinant Human TPR, His-tagged E.coli His
Rat TPR-6248R Recombinant Rat TPR Protein Mammalian Cell His
Rat TPR-5905R Recombinant Rat TPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TPR-5905R-B Recombinant Rat TPR Protein Pre-coupled Magnetic Beads HEK293
Trypanosoma Cruzi TPR-1748T Recombinant Trypanosoma Cruzi TPR Protein (1-492 aa), His-tagged Yeast His 1-492 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TPR Related Articles

TPR involved in several pathways and played different roles in them. We selected most pathways TPR participated on our site, such as RNA transport, Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RNA transportPOM121L2;NCBP1;POP4;EEF1A1L2;POP7;EIF2B5;THOC5;EIF4G2;UPF3B
Pathways in cancerAKT1;RAC1;MAPK8;PTK2;PRKCA;PLCB2;HIF1A;MMP1;HDAC2
Thyroid cancerMAPK1;TFG;RET;LEF1;TP53;NTRK1;TPR;RXRG;BRAF

TPR has several biochemical functions, for example, chromatin binding, dynein complex binding, heat shock protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPR itself. We selected most functions TPR had, and list some proteins which have the same functions with TPR. You can find most of the proteins on our site.

Function Related Protein
chromatin bindingCUX1;COQ7;MSH6;APBB1;HDAC7;TP53;ACTL6A;MLL1;ORC1L
dynein complex bindingTPR;HDAC6;CCDC155
heat shock protein bindingDNAJA2;DNAJA2L;APAF1;BAX;IRAK1;DNAJA3A;CDC37L1;DNAJA3;HSPA8
mRNA bindingLIN28A;HNRPLL;SRRM4;AGO2;RPS2;QK;PAIP2;CPSF6;DCP1B
mitogen-activated protein kinase bindingACE;MAPKAPK2;DUSP2;ATF7;PTPRJ;TPR;NBR1;ARRB2;MAPKAPK2B
molecular_functionBHLHA9;DNALC1;GNB1L;XKR9;CBLN8;LSM12B;GOLIM4;PPFIBP2;ZSWIM4
nucleocytoplasmic transporter activityNUPL1;NUP133;UPF3A;NUP35;TPRB;NUP214;XPO1;NUP54;NUP160
poly(A) RNA bindingSRP54;RTN4;ARF1;SNRPA;RBMX;SUB1;RARS2;HNRNPDL;ADARB1
NOT protein anchor
protein bindingIKZF2;ARMC8;NUDCD2;KIAA1967;PYGM;FEM1B;AHNAK2;MED31;OLFM4
protein homodimerization activityMLL1;NPPC;USF2;CEP57;SP100;NBL1;DMBX1;ADRA2C;NPM1
NOT transporter activity
tubulin bindingSTMN1B;EML2;CLIP1;PARK2;STMN4;RITA1;TPPP;STMN4L;STMN2

TPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPR here. Most of them are supplied by our site. Hope this information will be useful for your research of TPR.

Mad2l1; MAD1L1; FOS; SMAD2; Tpr; Kifc1; TRAF6; APC; SF1; MAP3K4; midostaurin; Katna1; CBX7; FN1; VCAM1

Klein, JS; Jiang, SD; et al. Design and characterization of structured protein linkers with differing flexibilities. PROTEIN ENGINEERING DESIGN & SELECTION 27:325-330(2014).
Mansiaux, Y; Carrat, F; et al. Detection of independent associations in a large epidemiologic dataset: a comparison of random forests, boosted regression trees, conventional and penalized logistic regression for identifying independent factors associated with H1N1pdm influenza infections. BMC MEDICAL RESEARCH METHODOLOGY 14:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can TPR protein-based therapies be used for personalized medicine? 11/01/2022

Potentially, as TPR proteins play diverse roles in cellular processes, targeting them could lead to personalized therapeutic approaches for various diseases.

How are TPR proteins involved in cellular signaling? 02/27/2021

Some TPR proteins are involved in regulating cellular signaling pathways, influencing processes such as cell growth, differentiation, and apoptosis.

What role do TPR proteins play in mitochondrial function? 11/20/2020

Some TPR proteins are involved in regulating mitochondrial function, which could have implications for diseases related to mitochondrial dysfunction.

How are TPR proteins involved in cellular transport? 08/26/2020

TPR proteins are involved in the transport of proteins and other molecules within the cell, regulating the movement of cargo between different cellular compartments.

Can TPR proteins be used as therapeutic targets for neurodegenerative diseases? 04/20/2020

Research suggests that targeting TPR proteins involved in protein folding and transport could be a potential therapeutic approach for neurodegenerative diseases.

Customer Reviews (3)

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Reviews
06/18/2021

    Its consistent and accurate results, combined with its compatibility with various cutting-edge techniques, ensure that data collection and analysis are both reliable and meaningful.

    04/24/2020

      The manufacturer's commitment to delivering a high-quality product further enhances its reputation and guarantees its suitability for a wide range of research applications.

      06/06/2016

        The TPR protein's exceptional performance in ELISA and its successful application in protein electron microscopy structure analysis make it a highly reliable and recommended choice for researchers.

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