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TPX2

  • Official Full Name

    TPX2, microtubule-associated, homolog

  • Overview

    The TPX2 protein, also known as targeting protein for Xklp1, restricted expression proliferation associated protein p100, and differentially expressed in cancer and non-cancerous lung cells protein 2 (DIL2), is a 100 kD nuclear protein that contains two c
  • Synonyms

    TPX2; TPX2, microtubule-associated, homolog (Xenopus laevis); C20orf1, C20orf2, chromosome 20 open reading frame 1; targeting protein for Xklp2; DIL 2; p100; protein fls353; differentially expressed in lung cells; TPX2, microtubule-associated protein hom;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TPX2-7044H Recombinant Human TPX2, His-tagged Sf9 Insect Cell His Full length
Human TPX2-829HCL Recombinant Human TPX2 293 Cell Lysate HEK293 N/A
Human TPX2-1921H Recombinant Human TPX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TPX2-222HFL Active Recombinant Full Length Human TPX2 Protein, C-Flag-tagged Mammalian cells Flag
Human TPX2-2246H Recombinant Human TPX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TPX2-2246H-B Recombinant Human TPX2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TPX2-17278M Recombinant Mouse TPX2 Protein Mammalian Cell His
Mouse Tpx2-6615M Recombinant Mouse Tpx2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse TPX2-9552M-B Recombinant Mouse TPX2 Protein Pre-coupled Magnetic Beads HEK293
Mouse TPX2-9552M Recombinant Mouse TPX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken TPX2-6007C Recombinant Chicken TPX2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TPX2 Related Articles

TPX2 involved in several pathways and played different roles in them. We selected most pathways TPX2 participated on our site, such as Aurora A signaling, Gastric cancer network 1, PLK1 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Aurora A signalingTACC1;AURKB;CENPA;GADD45A;NDEL1;TACC3;OAZ1;TPX2;TDRD7
Gastric cancer network 1RNF216;ACTL6A;MYBL2;C21orf33;TOP2A;LIN9;ESM1;GATS;SMOC2
PLK1 signaling eventsTCTN2;TPT1;SPC24;ERCC6L;NDC80;ECT2;PLK1S1;TPX2;BORA

TPX2 has several biochemical functions, for example, ATP binding, GTP binding, importin-alpha family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TPX2 itself. We selected most functions TPX2 had, and list some proteins which have the same functions with TPX2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTSSK1;ABCB6;PMS2;MYH1E;DMPK;UBE2B;TBCK;UBE2I;JAK2A
GTP bindingTUBD1;ARL10;RHOV;HHAT;TUBAL3;ARL3;TUBA4A;EHD1B;RAB13
importin-alpha family protein bindingGOLGA2;RAN;TPX2
protein bindingAMPH;RUNX2;TSPO;MTPAP;STX11;ZKSCAN1;KDM5B;ATP5O;RNF149
protein kinase bindingNSF;EEF2;TNIP2;KCNQ3;FOXM1;RHOD;TSACC;TRAF4;GSK3B

TPX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TPX2.

AURKA; CDK6; NCK1; PIK3R1; CRK; GRB2; Mad2l1; NAP1L1; THAP11; pi3p; Rab7a; AFAP1; CDC5L; SAP130

Shagisultanova, E; Dunbrack, RL; et al. Issues in interpreting the in vivo activity of Aurora-A. EXPERT OPINION ON THERAPEUTIC TARGETS 19:187-200(2015).
Aref, AM; Hoa, NT; et al. HCA519/TPX2: a potential T-cell tumor-associated antigen for human hepatocellular carcinoma. ONCOTARGETS AND THERAPY 7:1061-1070(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does TPX2 interact with other cellular proteins, and what impact does this interaction have on cellular functions? 06/02/2019

TPX2 interacts with various proteins involved in spindle formation and cell cycle regulation, influencing cellular functions crucial for proper division.

Are there any drugs currently in development that target TPX2, and what challenges are associated with developing such drugs? 03/26/2019

Several drug development efforts are underway to target TPX2, but challenges include ensuring specificity and minimizing off-target effects.

Are there any ongoing clinical trials targeting TPX2 for cancer treatment? 07/13/2018

Several clinical trials are exploring the therapeutic potential of targeting TPX2 in cancer treatment, evaluating its role as a molecular target.

How does TPX2 impact the prognosis of cancer patients, and what correlations have been observed between TPX2 expression and patient outcomes? 10/30/2016

Elevated TPX2 expression is often linked to poor prognosis in cancer patients, indicating its potential as a prognostic marker.

In what ways is TPX2 linked to cancer, and how is it being explored as a potential therapeutic target? 03/07/2016

Abnormal expression or regulation of TPX2 is associated with various cancers, making it a potential target for cancer therapies aimed at disrupting uncontrolled cell division.

Customer Reviews (3)

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Reviews
04/16/2023

    The versatility and efficacy of TPX2 in these applications make it an invaluable tool for researchers.

    04/14/2020

      The TPX2 protein exhibits remarkable performance in Western blotting (WB) experiments.

      01/03/2020

        Researchers can rely on TPX2 to deliver reliable and accurate results in ELISA experiments, ensuring precise measurement and quantification of target proteins.

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